Patents by Inventor Thomas M. Estok

Thomas M. Estok has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of cancer with TG02
    Patent number: 11865116
    Abstract: The present disclosure provides therapeutic methods of treating a cancer patient with TG02 and a second therapeutic agent, e.g., TG02 and an immune checkpoint inhibitor, TG02 and a COX-2 inhibitor, or TG02 and an immune checkpoint inhibitor and a COX-2 inhibitor.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: January 9, 2024
    Assignee: COTHERA BIOSCIENCE, INC.
    Inventors: Thomas M. Estok, Eckard Weber, Tracy Lee Lawhon
  • LYOPHILIZED COMPOSITION COMPRISING (S)-ISOPROPYL 2-((S)-2-ACETAMIDO-3-(1H-INDOL-3-YL)PROPANAMIDO)-6-DIAZO-5-OXOHEXANOATE FOR SUBCUTANEOUS ADMINISTRATION AND THE USE THEREOF
    Publication number: 20230372294
    Abstract: The present disclosure provides lyophilates comprising (S)-isopropyl 2-((S)-2-acetamido-3-(1H-indol-3-yl)propanamido)-6-diazo-5-oxohexanoate: for subcutaneous administration to a subject, and pharmaceutical compositions, pharmaceutical formulations, and uses thereof
    Type: Application
    Filed: October 1, 2021
    Publication date: November 23, 2023
    Inventors: Steven DYKSTRA, Gary ELLIOT, Thomas M. ESTOK, Stuart R. GALLANT, Robert Christian WILD, Jianmin XU, Henry Acken HAVEL
  • LYOPHILIZED COMPOSITION COMPRISING (S)-ISOPROPYL 2-((S)-2-ACETAMIDO-3-(1H-INDOL-3-YL)PROPANAMIDO)-6-DIAZO-5-OXOHEXANOATE FOR INTRAVENOUS ADMINISTRATION AND THE USE THEREOF
    Publication number: 20220332676
    Abstract: The present disclosure provides lyophilates comprising (S)-isopropyl 2-((S)-2-acetamido-3-(1H-indol-3-yl)propanamido)-6-diazo-5-oxohexanoate: and pharmaceutical compositions, pharmaceutical formulations, and uses thereof.
    Type: Application
    Filed: October 2, 2020
    Publication date: October 20, 2022
    Inventors: Steven DYKSTRA, Gary ELLIOT, Thomas M. ESTOK, Stuart R. GALLANT, Robert Christian WILD, Jianmin XU, Henry Acken HAVEL
  • Use of TG02 for treating gliomas in pediatric subjects
    Patent number: 11173160
    Abstract: The present disclosure relates to uses of TG02, for treating a glioma in a pediatric human subject. In certain embodiments, the glioma can be a pediatric high-grade glioma (PHGG), e.g., a diffuse intrinsic pontine glioma (DIPG), and/or a H3.3-mutated glioma (e.g., a H3K27M-mutated glioma). The present disclosure further provides pharmaceutical compositions and kits that include an ERK5 inhibitor.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: November 16, 2021
    Assignees: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, ADASTRA PHARMACEUTICALS, INC.
    Inventors: Sameer Agnihotri, Alberto Broniscer, Ian F. Pollack, Thomas M. Estok
  • USE OF TG02 FOR TREATING GLIOMAS IN PEDIATRIC SUBJECTS
    Publication number: 20200368242
    Abstract: The present disclosure relates to uses of TG02, for treating a glioma in a pediatric human subject. In certain embodiments, the glioma can be a pediatric high-grade glioma (PHGG), e.g., a diffuse intrinsic pontine glioma (DIPG), and/or a H3.3-mutated glioma (e.g., a H3K27M-mutated glioma). The present disclosure further provides pharmaceutical compositions and kits that include an ERK5 inhibitor.
    Type: Application
    Filed: August 12, 2020
    Publication date: November 26, 2020
    Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, ADASTRA PHARMACEUTICALS, INC.
    Inventors: Sameer AGNIHOTRI, Alberto BRONISCER, Ian F. POLLACK, Thomas M. ESTOK
  • Treatment of Cancer with TG02
    Publication number: 20200323862
    Abstract: The present disclosure provides therapeutic methods of treating a cancer patient with TG02 and a second therapeutic agent, e.g., TG02 and an immune checkpoint inhibitor, TG02 and a COX-2 inhibitor, or TG02 and an immune checkpoint inhibitor and a COX-2 inhibitor.
    Type: Application
    Filed: March 24, 2017
    Publication date: October 15, 2020
    Inventors: Thomas M. ESTOK, Eckard WEBER, Tracy PARROTT
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER, TUMORS, AND TUMOR-RELATED DISORDERS
    Publication number: 20130084281
    Abstract: Described herein are compositions and methods for using these compositions in the treatment of cancer, tumors, and tumor-related disorders in a subject.
    Type: Application
    Filed: June 21, 2012
    Publication date: April 4, 2013
    Applicant: Tragara Pharmaceuticals, Inc.
    Inventors: Thomas M. Estok, Sara L. Zaknoen, Robert K. Mansfield, Tracy Lawhon
  • Methods and compositions for the treatment of cancer, tumors, and tumor-related disorders
    Patent number: 8247423
    Abstract: Described herein are compositions and methods for using these compositions in the treatment of cancer, tumors, and tumor-related disorders in a subject.
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: August 21, 2012
    Assignee: Tragara Pharmaceuticals, Inc.
    Inventors: Thomas M. Estok, Sara L. Zaknoen, Robert K. Mansfield, Tracy Lawhon
  • THERAPIES FOR TREATING CANCER USING COMBINATIONS OF COX-2 INHIBITORS AND ANTI-HER2(ERBB2) ANTIBODIES OR COMBINATIONS OF COX-2 INHIBITORS AND HER2(ERBB2) RECEPTOR TYROSINE KINASE INHIBITORS
    Publication number: 20120052061
    Abstract: Described herein are compositions and methods for using these compositions in the treatment of cancer, tumors, and tumor-related disorders in a subject.
    Type: Application
    Filed: September 23, 2008
    Publication date: March 1, 2012
    Applicant: Tragara Pharmaceuticals Inc.
    Inventors: Thomas M. Estok, Sara L. Zaknoen, Robert K. Mansfield, Tracy Lawhon
  • THERAPIES FOR TREATING CANCER USING COMBINATIONS OF COX-2 INHIBITORS AND AROMATASE INHIBITORS OR COMBINATIONS OF COX-2 INHIBITORS AND ESTROGEN RECEPTOR ANTAGONISTS
    Publication number: 20120015919
    Abstract: Described herein are compositions and methods for using these compositions in the treatment of cancer, tumors, and tumor-related disorders in a subject.
    Type: Application
    Filed: September 23, 2008
    Publication date: January 19, 2012
    Applicant: Tragara Pharmaceuticals, Inc.
    Inventors: Thomas M. Estok, Sara L. Zaknoen, Robert K. Mansfield, Tracy Lawhon
  • COMBINATION THERAPY FOR THE TREATMENT OF CANCER USING COX-2 INHIBITORS AND DUAL InHIBITORS OF EGFR [ErbB1] AND HER-2 [ErbB2]
    Publication number: 20110306572
    Abstract: Described herein are compositions and methods for using these compositions in the treatment of cancer, tumors, and tumor-related disorders in a subject.
    Type: Application
    Filed: September 23, 2008
    Publication date: December 15, 2011
    Applicant: TRAGARA PHARMACEUTICALS, INC
    Inventors: Thomas M. Estok, Sara L. Zaknoen, Robert K. Mansfield
  • METHODS OF TREATING OVARIAN CANCER
    Publication number: 20100112039
    Abstract: Disclosed are methods of treating ovarian cancer (e.g., epithelial ovarian cancer) using lonafarnib, a taxane (e.g., paclitaxel or docetaxel) and a platinum coordinator complex (e.g., carboplatin, cisplatin or oxaliplatin). Also disclosed are methods of treating ovarian cancer (e.g. epithelial ovarian cancer) using lonafarnib, paclitaxel and carboplatin. Also disclosed are methods of treating ovarian cancer using lonafarnib in combination with a liposomal doxorubicin.
    Type: Application
    Filed: October 23, 2007
    Publication date: May 6, 2010
    Applicant: SCHERING CORPORATION
    Inventors: Thomas M. Estok, Sara Zaknoen, Charles M. Baum
  • Methods and Compositions for the Treatment of Cancer, Tumors, and Tumor-Related Disorders
    Publication number: 20090017024
    Abstract: Described herein are compositions and methods for using these compositions in the treatment of cancer, tumors, and tumor-related disorders in a subject.
    Type: Application
    Filed: July 11, 2008
    Publication date: January 15, 2009
    Applicant: Tragara Pharmaceuticals, Inc.
    Inventors: Thomas M. Estok, Sara L. Zaknoen, Robert K. Mansfield, Tracy Lawhon