Patents by Inventor Thomas M. Gentle
Thomas M. Gentle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110091354Abstract: A system for disinfecting a room includes an enclosure having first and second air inlets and an air intake control assembly to selectably control air flow into the enclosure through the first and second air inlets. Air that flows between the exterior and interior of the enclosure through the second air inlet passes through a filter assembly. The enclosure also includes an air dispersion outlet having a fan that draws air into the enclosure through the first and second air inlets and forces air out of the enclosure. A chemical dispersion assembly generates a disinfecting fog relative to the fan. A system controller controls the air intake control assembly to disperse the disinfecting fog into the room, and subsequently draw the disinfecting fog from the room and through the filter assembly.Type: ApplicationFiled: October 14, 2010Publication date: April 21, 2011Applicant: MINNTECH CORPORATIONInventors: Mason Schwartz, Thomas M. Gentle, Michael P. Petersen
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Patent number: 7645613Abstract: Mass spectrometry techniques for determining the status of sepsis in an individual are provided. A biomarker profile resolved from a biological sample, taken from the individual, using a mass spectrometry technique is compared to a reference biomarker profile. A single such comparison classifies the individual as belonging to or not belonging to a reference population. The individual's biomarker profile and the reference biomarker profile comprise a plurality of ions each having a mass-to-charge ratio of about 100 Daltons to about 1000 Daltons. The plurality of ions can be detected by electrospray ionization mass spectrometry in positive mode. The comparison uses a decision rule, such as a classification tree, that determines the status of sepsis in the individual without requiring knowledge of the identity of the biomarkers in the biomarker profile from the individual and without requiring knowledge of the identity of the biomarkers in the reference biomarker profile.Type: GrantFiled: December 28, 2006Date of Patent: January 12, 2010Assignee: Becton, Dickinson and CompanyInventors: Richard M. Ivey, Thomas M. Gentle, Jr., Richard L. Moore, Michael L. Towns, Gary Siuzdak, Elizabeth J. Want, Zhouxin Shen, Nicholas Bachur, Jr., Robert W. Rosenstein, James G. Nadeau, Paul E. Goldenbaum, Song Shi, Donald Copertino, James Garrett, Gregory Tice
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Patent number: 7645573Abstract: The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished using a molecular diagnostics approach, involving comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population who develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms.Type: GrantFiled: November 12, 2003Date of Patent: January 12, 2010Assignee: Becton, Dickinson and CompanyInventors: Richard M. Ivey, Thomas M. Gentle, Jr., Richard L. Moore, Michael L. Towns, Nicholas Bachur, Jr., Robert W. Rosenstein, Paul E. Goldenbaum, Song Shi, Donald Copertino, James Garrett, Gregory Tice
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Patent number: 7632685Abstract: Mass spectrometry techniques for determining the status of sepsis in an individual are provided. A biomarker profile resolved from a biological sample, taken from the individual, using a mass spectrometry technique is compared to a reference biomarker profile. A single such comparison classifies the individual as belonging to or not belonging to a reference population. The individual's biomarker profile and the reference biomarker profile comprise a plurality of ions each having a mass-to-charge ratio of about 100 Daltons to about 1000 Daltons. The plurality of ions can be detected by electrospray ionization mass spectrometry in positive mode. The comparison uses a decision rule, such as a classification tree, that determines the status of sepsis in the individual without requiring knowledge of the identity of the biomarkers in the biomarker profile from the individual and without requiring knowledge of the identity of the biomarkers in the reference biomarker profile.Type: GrantFiled: December 28, 2006Date of Patent: December 15, 2009Assignee: Becton, Dickinson and CompanyInventors: Richard M. Ivey, Thomas M. Gentle, Jr., Richard L. Moore, Michael L. Towns, Nicholas Bachur, Jr., Robert W. Rosenstein, James G. Nadeau, Paul E. Goldenbaum, Song Shi, Donald Copertino, James Garrett, Gregory Tice, Gary Siuzdak, Elizabeth Want, Zhouxin Shen
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Publication number: 20080138832Abstract: The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished by comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated from the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis.Type: ApplicationFiled: September 25, 2007Publication date: June 12, 2008Applicant: Becton, Dickinson and CompanyInventors: Richard M. Ivey, Thomas M. Gentle, Richard L. Moore, Michael L. Towns, Nicholas Bachur, Robert W. Rosenstein, James G. Nadeau, Paul E. Goldenbaum, Song Shi, Donald Copertino, James Garrett, Gregory Tice
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Publication number: 20070184512Abstract: Mass spectrometry techniques for determining the status of sepsis in an individual are provided. A biomarker profile resolved from a biological sample, taken from the individual, using a mass spectrometry technique is compared to a reference biomarker profile. A single such comparison classifies the individual as belonging to or not belonging to a reference population. The individual's biomarker profile and the reference biomarker profile comprise a plurality of ions each having a mass-to-charge ratio of about 100 Daltons to about 1000 Daltons. The plurality of ions can be detected by electrospray ionization mass spectrometry in positive mode. The comparison uses a decision rule, such as a classification tree, that determines the status of sepsis in the individual without requiring knowledge of the identity of the biomarkers in the biomarker profile from the individual and without requiring knowledge of the identity of the biomarkers in the reference biomarker profile.Type: ApplicationFiled: December 28, 2006Publication date: August 9, 2007Applicant: Becton, Dickinson and CompanyInventors: Richard M. Ivey, Thomas M. Gentle, Richard L. Moore, Michael L. Towns, Nicholas Bachur, Robert W. Rosenstein, James G. Nadeau, Paul E. Goldenbaum, Song Shi, Donald Copertino, James Garrett, Gregory Tice, Gary Siuzdak, Elizabeth Want, Zhouxin Shen
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Publication number: 20040157242Abstract: The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished by comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population who develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms.Type: ApplicationFiled: November 12, 2003Publication date: August 12, 2004Applicant: Becton, Dickinson and CompanyInventors: Richard M. Ivey, Thomas M. Gentle, Richard L. Moore, Michael L. Towns, Nicholas Bachur, Robert W. Rosenstein, James G. Nadeau, Paul E. Goldenbaum, Song Shi, Donald Copertino, James Garrett, Gregory Tice, Gary Siuzdak, Elizabeth Want, Zhouxin Shen
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Publication number: 20040106142Abstract: The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished using a molecular diagnostics approach, involving comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population who develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms.Type: ApplicationFiled: November 12, 2003Publication date: June 3, 2004Applicant: Becton, Dickinson and CompanyInventors: Richard M. Ivey, Thomas M. Gentle, Richard L. Moore, Michael L. Towns, Nicholas Bachur, Robert W. Rosenstein, Paul E. Goldenbaum, Song Shi, Donald Copertino, James Garrett, Gregory Tice
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Publication number: 20040096917Abstract: The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished by comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated from the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis.Type: ApplicationFiled: November 12, 2003Publication date: May 20, 2004Applicant: Becton, Dickinson and CompanyInventors: Richard M. Ivey, Thomas M. Gentle, Richard L. Moore, Michael L. Towns, Nicholas Bachur, Robert W. Rosenstein, James G. Nadeau, Paul E. Goldenbaum, Song Shi, Donald Copertino, James Garrett, Gregory Tice
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Publication number: 20040097460Abstract: The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished using a molecular diagnostics approach, involving comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis.Type: ApplicationFiled: November 12, 2003Publication date: May 20, 2004Applicant: Becton, Dickinson and CompanyInventors: Richard M. Ivey, Thomas M. Gentle, Richard L. Moore, Michael L. Towns, Nicholas Bachur, Robert W. Rosenstein, Paul E. Goldenbaum, Song Shi, Donald Copertino, James Garrett, Gregory Tice
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Patent number: 6432665Abstract: The present invention relates to a transparent sample container containing, preferably, a liquid bacterial growth media for detecting microbacteria and a process for detecting microbacteria using this sample container. The container is optically transparent, heat resistant, and stable during storage. The container and process provide a bacterial growth medium substantially free of contamination upon prolonged storage of preferably about one year at 40° C.Type: GrantFiled: February 3, 2000Date of Patent: August 13, 2002Assignee: Becton, Dickinson and CompanyInventors: Gregory Tice, Ming-Hsiung Yeh, Thomas M. Gentle, Jr., Timothy M. Sullivan
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Patent number: 6432697Abstract: The present invention relates to a transparent sample container containing, preferably, a liquid bacterial growth media for detecting microbacteria and a process for detecting microbacteria using this sample container. The container is optically transparent, heat resistant, and stable during storage. The container and process provide a bacterial growth medium substantially free of contamination upon prolonged storage of preferably about one year at 40° C.Type: GrantFiled: February 3, 2000Date of Patent: August 13, 2002Assignee: Becton, Dickinson and CompanyInventors: Gregory Tice, Ming-Hsiung Yeh, Thomas M. Gentle, Jr., Timothy M. Sullivan
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Patent number: 5998517Abstract: The present invention relates to a composition for the detection of the growth of respiring microorganisms in a sample, which comprises:(a) tris(4,7-diphenyl-10-phenanthroline)ruthenium dichloride pentahydrate;(b) a hydroxyl functional group;(c) an organosilicon polymer;(d) an organohydrogensilicon compound; and(e) a catalyst;and a method for preparing said composition.Type: GrantFiled: June 5, 1998Date of Patent: December 7, 1999Assignee: Becton, Dickinson and CompanyInventors: Thomas M. Gentle, Jr., Ming-Hsiung Yeh
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Patent number: 5516832Abstract: The present invention relates to a peroxide-curable silicone rubber composition which, when cured, exhibits a reduced modulus and improved tear strength relative to prior art systems without sacrificing other desirable properties, such as high tensile strength of the cured rubber or storage stability of the uncured rubber base, said composition comprising:(A) 100 parts by weight of a diorganopolysiloxane gum;(B) 10 to 75 parts by weight a reinforcing filler;(C) a polybutylene oligomer having a number average molecular weight of 200 to less than 900 and having functionality selected from the group consisting of epoxy, alkoxyphenylene, hydroxyl, carboxyl, anhydride and fully saturated; and, optionally,(D) a hydroxy-terminated diorganopolysiloxane having a degree of polymerization of 2 to 50.Type: GrantFiled: November 3, 1994Date of Patent: May 14, 1996Assignee: Dow Corning CorporationInventors: Linda D. Kennan, Thomas M. Gentle, Dale E. Hauenstein, Paul J. Popa
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Patent number: 5514419Abstract: There is disclosed a method for treating and protecting a substrate, said method comprising coating the surface of said substrate with a composition comprising a blend of(A) a polydimethylsiloxane polymer having a viscosity at 25.degree. C. of 5 to 100,000 cS; and(B) a polyisobutylene oligomer having a number average molecular weight of 200 to 550. The treatment imparts an aesthetically pleasing appearance to the surfaces of plastic, rubber or leather substrates whereby surface gloss is enhanced, but not excessively, as is the case for a comparable all-silicone treating agent.Type: GrantFiled: October 4, 1994Date of Patent: May 7, 1996Assignee: Dow Corning CorporationInventors: Paul J. Popa, Linda D. Kennan, Thomas M. Gentle, Dale E. Hauenstein
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Patent number: 5507960Abstract: There is disclosed a method for treating and protecting a substrate, said method comprising coating the surface of said substrate with a composition comprising a blend of(A) a polydimethylsiloxane polymer having a viscosity at 25.degree. C. of 5 to 100,000 cS; and(B) a polyisobutylene oligomer having a number average molecular weight of 200 to 550. The treatment imparts an aesthetically pleasing appearance to the surfaces of plastic, rubber or leather substrates whereby surface gloss is enhanced, but not excessively, as is the case for a comparable all-silicone treating agent.Type: GrantFiled: June 7, 1995Date of Patent: April 16, 1996Assignee: Dow Corning CorporationInventors: Paul J. Popa, Linda D. Kennan, Thomas M. Gentle, Dale E. Hauenstein
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Patent number: 5480930Abstract: The present invention describes uncured fluorocarbon elastomer base compositions and cured fluorocarbon elastomer compositions comprising a fluorocarbon elastomer, an amorphous silicone resin, and optionally a polydiorganosiloxane gum or a hydrocarbon polymer elastomer. The cured fluorocarbon elastomers typically contain additional components such as an acid acceptor, a cure agent, and a filler. The cured compositions have high strength, low temperature flexibility, high solvent resistivity, and low fuel permeability.Type: GrantFiled: August 18, 1994Date of Patent: January 2, 1996Assignee: Dow Corning CorporationInventors: Thomas M. Gentle, Gerald A. Gornowicz
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Patent number: 5442010Abstract: A composition is disclosed, said composition comprising(A) a polydimethylsiloxane having a viscosity greater than about 2 cS at 25.degree. C.; and(B) a polyisobutylene oligomer having a number average molecular weight of about 200 to about 3,000 and having at least one end terminated with an epoxy-containing group, the weight ratio of said polydimethylsiloxane (A) to said polyisobutylene (B) being in the range 1:99 to 99:1.Type: GrantFiled: October 4, 1994Date of Patent: August 15, 1995Assignee: Dow Corning CorporationInventors: Dale E. Hauenstein, Thomas M. Gentle, Linda D. Kennan, Paul J. Popa
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Patent number: 5421866Abstract: An aqueous emulsion composition suitable for treating cellulosic or masonry surfaces to render them water repellent is disclosed, said composition comprising:(i) an alkoxysilane of the formulaR.sub.n Si(OR').sub.4-nwherein R is an alkyl radical, an alkenyl radical, phenyl, chloropropyl or trifluoropropyl, n is 1 or 2 and R' is an alkyl radical having 1 to 6 carbon atoms;(ii) a silane coupling agent of the formulaR".sub.m R'".sub.p Si(OR').sub.4-m-pwherein R" is selected from the group consisting of amino and quaternary ammonium organofunctional groups, R'" is an alkyl radical having 1 to 4 carbon atoms, R' has its previously defined meaning, m is 1 or 2 and p is 0 or 1, with the proviso that m+p is 2 or less and the molar ratio of said alkoxysilane (i) to said silane coupling agent (ii) is 0.5:1 to 3:1; and (iii) a polyisobutylene polymer, and preferred emulsions of the invention further comprising a wax component.Type: GrantFiled: May 16, 1994Date of Patent: June 6, 1995Assignee: Dow Corning CorporationInventors: Lori A. Stark-Kasley, Paul J. Popa, Thomas M. Gentle, Dale E. Hauenstein, Linda D. Kennan
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Patent number: 5169561Abstract: A defoamer composition including a primary antifoam agent which includes a particulate-type material having a high surface area such as silica, a secondary antifoam agent for acting synergistically with the primary antifoam agent such as polydimethylsiloxane, a water carrier, and a quaternary ammonium salt silane compound which functions as an antimicrobial agent, fixed and adhered to the surface of the particulate material, in order that the defoamer composition be resistant to biological degradation due to the presence in the system of microorganisms. Methods of defoaming cationic, anionic, and nonionic surfactant produced foams are disclosed, as is a method of rendering silica hydrophobic.Type: GrantFiled: April 8, 1991Date of Patent: December 8, 1992Assignee: Dow Corning CorporationInventors: Thomas M. Gentle, William C. White