Patents by Inventor Thomas M. Hering

Thomas M. Hering has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7365181
    Abstract: Markers for detecting and staging chondrogenesis in cells are provided. In one aspect the markers are isolated polynucleotides, referred to hereinafter as CZF-1 and CZF-2, and fragments thereof. In one embodiment, the CZF-1 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO.1. In one embodiment, the CZF-2 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO. 3. In another aspect the markers are antibodies, which are immunospecific for proteins encoded by CZF-1 or CZF-2. Methods which employ the present markers to identify cells that have begun to differentiate into chondrocytes are provided. The present invention also relates to the CZ-1 protein and the CZ-2 protein and to polynucleotides or oligonucleotides whose sequences are complementary to the coding sequences of CZF-1 or CZF-2, or regions thereof.
    Type: Grant
    Filed: July 21, 2003
    Date of Patent: April 29, 2008
    Assignee: Case Western Reserve University
    Inventors: Thomas M. Hering, Brian Johnstone
  • Patent number: 6596855
    Abstract: Markers for detecting and staging chondrogenesis in cells are provided. In one aspect the markers are isolated polynucleotides, referred to hereinafter as CZF-1 and CZF-2, and fragments thereof. In one embodiment, the CZF-1 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO.1. In one embodiment, the CZF-2 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO. 3. In another aspect the markers are antibodies, which are immunospecific for proteins encoded by CZF-1 or CZF-2. Methods which employ the present markers to identify cells that have begun to differentiate into chondrocytes are provided. The present invention also relates to the CZ-1 protein and the CZ-2 protein and to polynucleotides or oligonucleotides whose sequences are complementary to the coding sequences of CZF-1 or CZF-2, or regions thereof.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: July 22, 2003
    Assignee: Case Western Reserve University
    Inventors: Thomas M. Hering, Brian Johnstone
  • Publication number: 20030039966
    Abstract: Markers for detecting and staging chondrogenesis in cells are provided. In one aspect the markers are isolated polynucleotides, referred to hereinafter as CZF-1 and CZF-2, and fragments thereof. In one embodiment, the CZF-1 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO. 1. In one embodiment, the CZF-2 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO. 3. In another aspect the markers are antibodies, which are immunospecific for proteins encoded by CZFI-1 or CZF-2. Methods which employ the present markers to identify cells that have begun to differentiate into chondrocytes are provided. The present invention also relates to the CZ-1 protein and the CZ-2 protein and to polynucleotides or oligonucleotides whose sequences are complementary to the coding sequences of CZF-1 or CZF-2, or regions thereof.
    Type: Application
    Filed: June 14, 2001
    Publication date: February 27, 2003
    Inventors: Thomas M. Hering, Brian Johnstone