Patents by Inventor Thomas M. Jovin

Thomas M. Jovin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10969573
    Abstract: A spatio-temporally light modulated imaging system for confocal imaging an object includes a light modulating micro-mirror device, an imaging optic, and a camera device, wherein a carrier wheel device is provided for carrying multiple pairs of first and second dichroic beam splitters and multiple pairs of first and second emission filters, wherein the carrier wheel device is adjustable in multiple operational positions relative to the first and second optical axes, and wherein a casing is provided. Furthermore, a carrier wheel device for carrying optical members and a method for confocal imaging an object are disclosed.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: April 6, 2021
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Thomas M. Jovin, Anthony De Vries, Tobias Freund
  • Publication number: 20210003834
    Abstract: Optical confocal imaging, being conducted with a programmable array microscope (PAM) (100), having a light source device (10), a spatial light modulator device (20) with a plurality of reflecting modulator elements, a PAM objective lens and a camera device (30), wherein the spatial light modulator device (20) is configured such that first groups of modulator elements (21) are selectable for directing excitation light to conjugate locations of an object to be investigated and for directing detection light originating from these locations to the camera device (30), and second groups of modulator elements (22) are selectable for directing detection light from non-conjugate locations of the object to the camera device (30), comprises the steps of directing excitation light from the light source device (10) via the first groups of modulator elements to the object to be investigated, wherein the spatial light modulator device (20) is controlled such that a predetermined pattern sequence of illumination spots is foc
    Type: Application
    Filed: December 20, 2017
    Publication date: January 7, 2021
    Inventors: Thomas M. JOVIN, Anthony H. B. DE VRIES, Donna J. ARNDT-JOVIN
  • Publication number: 20200165279
    Abstract: The present invention relates to a compound represented by the formula (E) which is useful for treating or preventing melanoma.
    Type: Application
    Filed: May 11, 2018
    Publication date: May 28, 2020
    Applicants: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V., LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN, GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN
    Inventors: Dorothea BECKER, Thomas M. JOVIN, Christian GRIESINGER, Andrei LEONOV, Sergey RYAZANOV, Armin GIESE, Tiago F. OUTEIRO, Diana F. LAZARO, Michael P. SCHÖN, Margarete SCHÖN
  • Patent number: 10274427
    Abstract: An emission lifetime measuring method, in particular for measuring a mean lifetime of electronically excited states of a sample, comprises the steps of illuminating the sample with at least one excitation light pulse, time-resolved detecting an emission response from the sample and creating a temporal detector response function, and calculating the mean lifetime of the electronically excited states on the basis of the detector response function, wherein the at least one excitation light pulse is shaped such that the sample achieves an equilibrium excited steady-state including a linearly increasing or constant number of the electronically excited states, the detector response function has a linear response function section with a constant slope, and the mean lifetime (?) of the electronically excited states is calculated on the basis of at least one of a time position of the linear response function section relative to a reference time of the at least one excitation light pulse and the slope of the linear res
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: April 30, 2019
    Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Thomas M. Jovin, Nathan P. Cook
  • Publication number: 20190107698
    Abstract: A spatio-temporally light modulated imaging system (100) for confocal imaging an object (1) comprises a light modulating micro-mirror device (110) with an array of mirror elements, an imaging optic (120) being arranged for focusing illumination light from the micro-mirror device (110) onto the object (1) and directing detection light created in the object (1) in response to the illumination light towards the micro-mirror device (110), and a camera device (130) with at least one detector camera (131, 132) being arranged for collecting the detection light travelling via the mirror elements and a first optical relaying device (140) on a first optical axis (143), and for collecting the detection light travelling via the mirror elements and a second optical relaying device (150) on a second optical axis (153), wherein a camera body (135, 136) of the at least one detector camera (131, 132) is arranged with a vertical camera axis (137, 138), and at least one deflecting mirror (161, 162) is arranged for deflecting th
    Type: Application
    Filed: March 24, 2016
    Publication date: April 11, 2019
    Inventors: Thomas M. JOVIN, Anthony De VRIES, Tobias FREUND, Sebastian DURST
  • Publication number: 20190107710
    Abstract: A spatio-temporally light modulated imaging system (100) for confocal imaging an object (1) comprises a light modulating micro-mirror device (110), an imaging optic (120), and a camera device (130), wherein a carrier wheel device (200) is provided for carrying multiple pairs of first and second dichroic beam splitters (211) and multiple pairs of first and second emission filters (221), wherein the carrier wheel device (200) is adjustable in multiple operational positions relative to the first and second optical axes (143, 153), and wherein a casing (111) is provided. Furthermore, a carrier wheel device (200) for carrying optical members (211, 221) and a method for confocal imaging an object (1) are disclosed.
    Type: Application
    Filed: March 24, 2016
    Publication date: April 11, 2019
    Inventors: Thomas M. JOVIN, Anthony DE VRIES, Tobias FREUND
  • Publication number: 20190003969
    Abstract: An emission lifetime measuring method, in particular for measuring a mean lifetime of electronically excited states of a sample, comprises the steps of illuminating the sample with at least one excitation light pulse, time-resolved detecting an emission response from the sample and creating a temporal detector response function, and calculating the mean lifetime of the electronically excited states on the basis of the detector response function, wherein the at least one excitation light pulse is shaped such that the sample achieves an equilibrium excited steady-state including a linearly increasing or constant number of the electronically excited states, the detector response function has a linear response function section with a constant slope, and the mean lifetime (?) of the electronically Diode current and pulse width control excited states is calculated on the basis of at least one of a time position of the linear response function section relative to a reference time of the at least one excitation light
    Type: Application
    Filed: January 13, 2016
    Publication date: January 3, 2019
    Inventors: Thomas M. JOVIN, Nathan P. COOK
  • Patent number: 9279971
    Abstract: An optical modulator device (100), in particular for a spatio-temporally light modulated imaging system (200), comprises a light modulating micro-mirror device (110) comprising an array of mirror elements (111) arranged in a modulator plane (112), wherein each of the mirror elements (111) can be switched individually between first (111a) and second (111b) states with first and second tilting angles, resp., relative to a modulator optical axis (113) perpendicular to the modulator plane (112), and a first optical relaying device (120) being arranged for relaying light between the mirror elements (111) in the first (111a) state and a first optical axis (121) deviating from the modulator optical axis (113), wherein the first optical relaying device (120) includes a first group of imaging elements (122, 123, 124) being formed such that a planar light field (114) perpendicular to the modulator optical axis (113) is relayed to a first planar light field (125) perpendicular to the first optical axis (121).
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: March 8, 2016
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Thomas M. Jovin, Wouter Caarls, Anthony De Vries
  • Publication number: 20130063586
    Abstract: An optical modulator device (100), in particular for a spatio-temporally light modulated imaging system (200), comprises a light modulating micro-mirror device (110) comprising an array of mirror elements (111) arranged in a modulator plane (112), wherein each of the mirror elements (111) can be switched individually between first (111a) and second (111b) states with first and second tilting angles, resp., relative to a modulator optical axis (113) perpendicular to the modulator plane (112), and a first optical relaying device (120) being arranged for relaying light between the mirror elements (111) in the first (111a) state and a first optical axis (121) deviating from the modulator optical axis (113), wherein the first optical relaying device (120) includes a first group of imaging elements (122, 123, 124) being formed such that a planar light field (114) perpendicular to the modulator optical axis (113) is relayed to a first planar light field (125) perpendicular to the first optical axis (121).
    Type: Application
    Filed: March 18, 2011
    Publication date: March 14, 2013
    Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Thomas M. Jovin, Wouter Caarls, Anthony De Vries
  • Publication number: 20090098596
    Abstract: A fluorogenic dye having the formula and salts of said fluorogenic dyes.
    Type: Application
    Filed: December 11, 2008
    Publication date: April 16, 2009
    Applicant: Max-Planck Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Elisabeth A. Jares-Erijman, Carla C. Spagnuolo, Rolf J. Vermeij, Thomas M. Jovin
  • Patent number: 6399935
    Abstract: A confocal optical imaging system comprises light source means (110, 310, 410, 710), detector means (150, 160, 350, 360, 450, 750) with at least one two-dimensional detector camera, and spatial light modulator means (120, 320, 420, 720) with a first (121a) and a second group (121b) of modulator elements, wherein the first group of modulator elements is adapted to illuminate an object to be investigated according to a predetermined pattern sequence of illumination spots focused to conjugate locations (141, 341, 441) of the object from which detection light is directed to the detector means for forming a first image Ic, and the second group of elements is adapted to illuminate the object at non-conjugate locations and/or to direct detection light from non-conjugate locations of the object to the detector means for forming a second image Inc. In an optical imaging method using this system, the first and second images are collected simultaneously or subsequently.
    Type: Grant
    Filed: October 21, 1998
    Date of Patent: June 4, 2002
    Assignee: Max-Planck-Gesellschaft zur Forderung der Forderung der Wissenschaften E.V.
    Inventors: Thomas M. Jovin, Quentin Hanley, Peter Verveer
  • Patent number: 6128077
    Abstract: A confocal spectral imaging system comprises a light source, a light modulator forming an illumination aperture and directing an illumination pattern to conjugate object locations, and analyzing means with a detection aperture, dispersive elements and a detector, wherein the illumination and detection apertures are in conjugate optical planes, and the light modulator consist of an array of light modulator elements, a group of which being arranged according to the illumination pattern and forming the illumination aperture, and are controlled such that the illumination pattern is directed to time-dependent changing conjugate locations of the object.
    Type: Grant
    Filed: November 17, 1998
    Date of Patent: October 3, 2000
    Inventors: Thomas M. Jovin, Quentin Hanley, Peter Verveer
  • Patent number: 4076420
    Abstract: A reaction kinetics measuring system which provides for the application of great variety of reaction initiating methods, as temperature or pressure or electrical field jump methods, mixing methods, flash photolysis method, and combinations of said methods, and for various optical detection methods, as absorption or fluorescence or scattered light or polarized light detection methods. The system features quickly and easily interchangeable optical elements in a number of optical paths, and a multitude of selectively usable measuring cells to adapt the system to the reaction initiating and detection methods used so that reliable and exactly reproducible results are obtained, which are comparable even if obtained under widely differing conditions.
    Type: Grant
    Filed: August 19, 1974
    Date of Patent: February 28, 1978
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
    Inventors: Leo C. M. De Maeyer, Carl-Roland Rabl, Thomas M. Jovin, Detlev Riesner, Rudolf Rigler, Lutz Bodo Veil, Hans Lehrach