Abstract: The present invention relates to a compound represented by the formula (E) which is useful for treating or preventing melanoma.

Abstract: A spatio-temporally light modulated imaging system and method for confocal imaging an object is disclosed. The imaging system may include a light modulating micro-mirror device with an array of mirror elements, an imaging optic for focusing illumination light from the micro-mirror device onto the object and directing detection light created in the object in response to the illumination light towards the micro-mirror device, and a camera device with a detector camera for collecting the detection light travelling via the mirror elements and a first optical relaying device on a first optical axis, and for collecting the detection light travelling via the mirror elements and a second optical relaying device on a second optical axis, wherein a camera body of the detector camera is arranged with a vertical camera axis, and a deflecting mirror is arranged for deflecting the detection light from the optical axes to the vertical camera axis.

Abstract: A spatio-temporally light modulated imaging system for confocal imaging an object includes a light modulating micro-mirror device, an imaging optic, and a camera device, wherein a carrier wheel device is provided for carrying multiple pairs of first and second dichroic beam splitters and multiple pairs of first and second emission filters, wherein the carrier wheel device is adjustable in multiple operational positions relative to the first and second optical axes, and wherein a casing is provided. Furthermore, a carrier wheel device for carrying optical members and a method for confocal imaging an object are disclosed.

Abstract: Optical confocal imaging, being conducted with a programmable array microscope (PAM) (100), having a light source device (10), a spatial light modulator device (20) with a plurality of reflecting modulator elements, a PAM objective lens and a camera device (30), wherein the spatial light modulator device (20) is configured such that first groups of modulator elements (21) are selectable for directing excitation light to conjugate locations of an object to be investigated and for directing detection light originating from these locations to the camera device (30), and second groups of modulator elements (22) are selectable for directing detection light from non-conjugate locations of the object to the camera device (30), comprises the steps of directing excitation light from the light source device (10) via the first groups of modulator elements to the object to be investigated, wherein the spatial light modulator device (20) is controlled such that a predetermined pattern sequence of illumination spots is foc

Abstract: The present invention relates to a compound represented by the formula (E) which is useful for treating or preventing melanoma.

Abstract: An emission lifetime measuring method, in particular for measuring a mean lifetime of electronically excited states of a sample, comprises the steps of illuminating the sample with at least one excitation light pulse, time-resolved detecting an emission response from the sample and creating a temporal detector response function, and calculating the mean lifetime of the electronically excited states on the basis of the detector response function, wherein the at least one excitation light pulse is shaped such that the sample achieves an equilibrium excited steady-state including a linearly increasing or constant number of the electronically excited states, the detector response function has a linear response function section with a constant slope, and the mean lifetime (?) of the electronically excited states is calculated on the basis of at least one of a time position of the linear response function section relative to a reference time of the at least one excitation light pulse and the slope of the linear res

Abstract: A spatio-temporally light modulated imaging system (100) for confocal imaging an object (1) comprises a light modulating micro-mirror device (110) with an array of mirror elements, an imaging optic (120) being arranged for focusing illumination light from the micro-mirror device (110) onto the object (1) and directing detection light created in the object (1) in response to the illumination light towards the micro-mirror device (110), and a camera device (130) with at least one detector camera (131, 132) being arranged for collecting the detection light travelling via the mirror elements and a first optical relaying device (140) on a first optical axis (143), and for collecting the detection light travelling via the mirror elements and a second optical relaying device (150) on a second optical axis (153), wherein a camera body (135, 136) of the at least one detector camera (131, 132) is arranged with a vertical camera axis (137, 138), and at least one deflecting mirror (161, 162) is arranged for deflecting th

Abstract: A spatio-temporally light modulated imaging system (100) for confocal imaging an object (1) comprises a light modulating micro-mirror device (110), an imaging optic (120), and a camera device (130), wherein a carrier wheel device (200) is provided for carrying multiple pairs of first and second dichroic beam splitters (211) and multiple pairs of first and second emission filters (221), wherein the carrier wheel device (200) is adjustable in multiple operational positions relative to the first and second optical axes (143, 153), and wherein a casing (111) is provided. Furthermore, a carrier wheel device (200) for carrying optical members (211, 221) and a method for confocal imaging an object (1) are disclosed.

Abstract: An emission lifetime measuring method, in particular for measuring a mean lifetime of electronically excited states of a sample, comprises the steps of illuminating the sample with at least one excitation light pulse, time-resolved detecting an emission response from the sample and creating a temporal detector response function, and calculating the mean lifetime of the electronically excited states on the basis of the detector response function, wherein the at least one excitation light pulse is shaped such that the sample achieves an equilibrium excited steady-state including a linearly increasing or constant number of the electronically excited states, the detector response function has a linear response function section with a constant slope, and the mean lifetime (?) of the electronically Diode current and pulse width control excited states is calculated on the basis of at least one of a time position of the linear response function section relative to a reference time of the at least one excitation light

Abstract: An optical modulator device (100), in particular for a spatio-temporally light modulated imaging system (200), comprises a light modulating micro-mirror device (110) comprising an array of mirror elements (111) arranged in a modulator plane (112), wherein each of the mirror elements (111) can be switched individually between first (111a) and second (111b) states with first and second tilting angles, resp., relative to a modulator optical axis (113) perpendicular to the modulator plane (112), and a first optical relaying device (120) being arranged for relaying light between the mirror elements (111) in the first (111a) state and a first optical axis (121) deviating from the modulator optical axis (113), wherein the first optical relaying device (120) includes a first group of imaging elements (122, 123, 124) being formed such that a planar light field (114) perpendicular to the modulator optical axis (113) is relayed to a first planar light field (125) perpendicular to the first optical axis (121).

Abstract: An optical modulator device (100), in particular for a spatio-temporally light modulated imaging system (200), comprises a light modulating micro-mirror device (110) comprising an array of mirror elements (111) arranged in a modulator plane (112), wherein each of the mirror elements (111) can be switched individually between first (111a) and second (111b) states with first and second tilting angles, resp., relative to a modulator optical axis (113) perpendicular to the modulator plane (112), and a first optical relaying device (120) being arranged for relaying light between the mirror elements (111) in the first (111a) state and a first optical axis (121) deviating from the modulator optical axis (113), wherein the first optical relaying device (120) includes a first group of imaging elements (122, 123, 124) being formed such that a planar light field (114) perpendicular to the modulator optical axis (113) is relayed to a first planar light field (125) perpendicular to the first optical axis (121).

Abstract: A fluorogenic dye having the formula and salts of said fluorogenic dyes.

Abstract: A confocal optical imaging system comprises light source means (110, 310, 410, 710), detector means (150, 160, 350, 360, 450, 750) with at least one two-dimensional detector camera, and spatial light modulator means (120, 320, 420, 720) with a first (121a) and a second group (121b) of modulator elements, wherein the first group of modulator elements is adapted to illuminate an object to be investigated according to a predetermined pattern sequence of illumination spots focused to conjugate locations (141, 341, 441) of the object from which detection light is directed to the detector means for forming a first image Ic, and the second group of elements is adapted to illuminate the object at non-conjugate locations and/or to direct detection light from non-conjugate locations of the object to the detector means for forming a second image Inc. In an optical imaging method using this system, the first and second images are collected simultaneously or subsequently.

Abstract: A confocal spectral imaging system comprises a light source, a light modulator forming an illumination aperture and directing an illumination pattern to conjugate object locations, and analyzing means with a detection aperture, dispersive elements and a detector, wherein the illumination and detection apertures are in conjugate optical planes, and the light modulator consist of an array of light modulator elements, a group of which being arranged according to the illumination pattern and forming the illumination aperture, and are controlled such that the illumination pattern is directed to time-dependent changing conjugate locations of the object.

Abstract: A reaction kinetics measuring system which provides for the application of great variety of reaction initiating methods, as temperature or pressure or electrical field jump methods, mixing methods, flash photolysis method, and combinations of said methods, and for various optical detection methods, as absorption or fluorescence or scattered light or polarized light detection methods. The system features quickly and easily interchangeable optical elements in a number of optical paths, and a multitude of selectively usable measuring cells to adapt the system to the reaction initiating and detection methods used so that reliable and exactly reproducible results are obtained, which are comparable even if obtained under widely differing conditions.