Patents by Inventor Thomas M. Kundig

Thomas M. Kundig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of inducing a CTL response
    Patent number: 8372393
    Abstract: Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system. Antigen is delivered at a level sufficient to induce an immunologic CTL response in a mammal and the level of the antigen in the mammal's lymphatic system is maintained over time sufficient to maintain the immunologic CTL response. Also disclosed is an article of manufacture for delivering an antigen that induces a CTL response in an animal.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: February 12, 2013
    Assignee: Mannkind Corporation
    Inventors: Thomas M. Kündig, John J. L. Simard
  • Method of inducing a CTL response
    Publication number: 20120046638
    Abstract: Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system. Antigen is delivered at a level sufficient to induce an immunologic CTL response in a mammal and the level of the antigen in the mammal's lymphatic system is maintained over time sufficient to maintain the immunologic CTL response. Also disclosed is an article of manufacture for delivering an antigen that induces a CTL response in an animal.
    Type: Application
    Filed: May 3, 2006
    Publication date: February 23, 2012
    Inventors: Thomas M. Kundig, John J. L. Simard
  • Method of inducing a CTL response
    Publication number: 20090035252
    Abstract: Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system. Antigen is delivered at a level sufficient to induce an immunologic CTL response in a mammal and the level of the antigen in the mammal's lymphatic system is maintained over time sufficient to maintain the immunologic CTL response. Also disclosed is an article of manufacture for delivering an antigen that induces a CTL response in an animal.
    Type: Application
    Filed: May 3, 2006
    Publication date: February 5, 2009
    Inventors: Thomas M. Kundig, John J. L. Simard
  • Method of inducing a CTL response
    Patent number: 7364729
    Abstract: Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system. Antigen is delivered at a level sufficient to induce an immunologic CTL response in a mammal and the level of the antigen in the mammal's lymphatic system is maintained over time sufficient to maintain the immunologic CTL response. Also disclosed is an article of manufacture for delivering an antigen that induces a CTL response in an animal.
    Type: Grant
    Filed: December 19, 2005
    Date of Patent: April 29, 2008
    Assignee: Mannkind Corporation
    Inventors: Thomas M. Kündig, John J. L. Simard
  • Method of inducing a CTL response
    Patent number: 6994851
    Abstract: A method of inducing a cytotoxic T-lymphocyte (CTL) response to an antigen is disclosed. The method involves delivering the antigen to the lymphatic system of an animal regularly over a sustained period of time using, e.g., an osmotic pump. The method is advantageous over prior art methods for inducing a CTL response in that it does not require repetitive immunizations or the use of adjuvants. The method of the present invention can be used for the induction of CTLs in tumor or infectious disease immunotherapy.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: February 7, 2006
    Assignee: MannKind Corporation
    Inventors: Thomas M. Kundig, John L. Simard
  • Method of inducing a CTL response
    Patent number: 6977074
    Abstract: Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system. Antigen is delivered at a level sufficient to induce an immunologic CTL response in a mammal and the level of the antigen in the mammal's lymphatic system is maintained over time sufficient to maintain the immunologic CTL response. Also disclosed is an article of manufacture for delivering an antigen that induces a CTL response in an animal.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: December 20, 2005
    Assignee: Mannkind Corporation
    Inventors: Thomas M. Kündig, John J. L. Simard
  • Modulation of allergic response
    Patent number: 6773695
    Abstract: The modulation or elimination of an allergic condition according to the invention can be achieved by injecting small amounts of allergen directly into a lymph node, which greatly reduces the potential for side effects.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: August 10, 2004
    Assignee: MannKind Corporation
    Inventors: Thomas M. Kündig, Stephen J. McCormack
  • Modulation of allergic response
    Publication number: 20020061315
    Abstract: The modulation or elimination of an allergic condition according to the invention can be achieved by injecting small amounts of allergen directly into a lymph node, which greatly reduces the potential for side effects.
    Type: Application
    Filed: March 13, 2001
    Publication date: May 23, 2002
    Inventors: Thomas M. Kundig, Stephen J. McCormack
  • Method of inducing a CTL response
    Publication number: 20020007173
    Abstract: Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system. Antigen is delivered at a level sufficient to induce an immunologic CTL response in a mammal and the level of the antigen in the mammal's lymphatic system is maintained over time sufficient to maintain the immunologic CTL response. Also disclosed is an article of manufacture for delivering an antigen that induces a CTL response in an animal.
    Type: Application
    Filed: February 2, 2001
    Publication date: January 17, 2002
    Inventors: Thomas M. Kundig, John J. L. Simard