Abstract: Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, engaging an interventional device of a catheter system with clot material in a blood vessel and withdrawing the interventional device and the portion of the clot material through a guide catheter. In some embodiments, the catheter system can include an attachment/valve member coupled to a proximal portion of the guide catheter, and the method can include unsealing the attachment/valve member to facilitate withdrawing the interventional device through the attachment/valve member without significant retention of clot material within the attachment/valve member. The method can further include resealing and aspirating the guide catheter before advancing another interventional device to the clot material to again engage and remove clot material from the blood vessel.

Abstract: Disclosed herein are clot removal systems including steerable catheters, and associated systems and methods. In some embodiments, a clot removal system includes (i) an aspiration catheter having a proximal region and a distal region and (ii) a handle coupled to the proximal region of the catheter and having an actuator. The distal region of the catheter can include a deflectable member, and the clot removal system can include a pull wire extending between the actuator and the deflectable member. Actuation of the actuator is configured to pull the pull wire to deflect the deflectable member to deflect the distal region relative to the proximal region. The deflection can facilitate steering of the catheter to hard-to-reach (e.g., tortuous) portions of the anatomy of a patient.

Abstract: Disclosed herein are aspiration guide catheters having a pre-shaped distal portion configured to deflect away from a longitudinal axis of the catheter, and associated systems and methods. In some embodiments, an aspiration guide catheter includes an inner liner defining a lumen and having a proximal region and a distal region. The catheter further includes a braid of wires over the inner liner, and a wire coiled around the braid over at least a portion of the distal region of the inner liner. At least a portion of the braid over the distal region of the inner liner is configured to deflect away from a longitudinal axis of the proximal region. The catheter can further include an outer sheath over the braid, the wire, and the inner liner.

Abstract: Disclosed herein are devices, systems, and methods for adjustably tensioning sutures, such as sutures used to close a catheter access site of a human patient. In some embodiments, a suture tensioning device includes a housing and an actuation member slidably coupled to the housing. The housing can include a first through-hole and a second through-hole at least partially aligned along an axis. The actuation member can include a third-through-hole. The suture tensioning device can further include a biasing member operably coupled between the actuation member and the housing. The biasing member can bias the actuation member to a first position in which the third through-hole is offset from the axis. The actuation member is movable to a second position in which the third through-hole is at least partially aligned with the first and second through-holes along the axis.