Patents by Inventor Thomas M. Wengenack

Thomas M. Wengenack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Magnetic resonance imaging of amyloid plaque in the brain
    Patent number: 9320452
    Abstract: Amyloid plaque in the brain of a subject is imaged in an MRI system with or without the use of a contrast agent. Contrast is achieved using a spin-echo pulse sequence that is both respiratory gated and cardiac gated to reduce motion artifacts at the very high image resolution required to see plaque. A preparatory pulse sequence is used to insure longitudinal magnetization remains constant for all the acquired views even if the effective TR changes during the scan due to irregular breathing.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: April 26, 2016
    Assignees: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Michael G. Garwood, Clifford R. Jack, Jr., Joseph F Poduslo, Thomas M. Wengenack
  • Methods for detecting parenchymal plaques in vivo
    Publication number: 20090028789
    Abstract: Methods for detecting parenchymal plaque deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity for the extracellular deposit, to the living mammal. Isolated ?-amyloid peptides that are polyamine modified and labeled with a radioisotope or contrast agent also are described.
    Type: Application
    Filed: January 18, 2008
    Publication date: January 29, 2009
    Inventors: Joseph F. Poduslo, Geoffry L. Curran, Thomas M. Wengenack
  • Magnetic Resonance Imaging of Amyloid Plaque in the Brain
    Publication number: 20080262339
    Abstract: Amyloid plaque in the brain of a subject is imaged in an MRI system with or without the use of a contrast agent. Contrast is achieved using a spin-echo pulse sequence that is both respiratory gated and cardiac gated to reduce motion artifacts at the very high image resolution required to see plaque. A preparatory pulse sequence is used to insure longitudinal magnetization remains constant for all the acquired views even if the effective TR changes during the scan due to irregular breathing.
    Type: Application
    Filed: June 28, 2005
    Publication date: October 23, 2008
    Inventors: Michael G. Garwood, Clifford R. Jack, Joseph F. Poduslo, Thomas M. Wengenack
  • Methods for detecting parenchymal plaques in vivo
    Patent number: 7371365
    Abstract: Methods for detecting parenchymal plaque deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity for the extracellular deposit, to the living mammal. Isolated ?-amyloid peptides that are polyamine modified and labeled with a radioisotope or contrast agent also are described.
    Type: Grant
    Filed: January 27, 2003
    Date of Patent: May 13, 2008
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Joseph F. Poduslo, Geoffrey L. Curran, Thomas M. Wengenack
  • Amino acid composition with increased blood brain barrier permeability
    Patent number: 7279149
    Abstract: An amino acid composition with improved blood brain barrier permeability comprising an amino acid polymer, wherein the amino acid comprises at least one asparagyl-4-aminobutane or glutamyl-4-aminobutane residue.
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: October 9, 2007
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Joseph F. Poduslo, Geoffrey L. Curran, Thomas M. Wengenack, Daniel J. McCormick, Abdul H. Fauq
  • Methods for detecting parenchymal plaques in vivo
    Publication number: 20040022736
    Abstract: Methods for detecting parenchymal plaque deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity for the extracellular deposit, to the living mammal. Isolated &bgr;-amyloid peptides that are polyamine modified and labeled with a radioisotope or contrast agent also are described.
    Type: Application
    Filed: January 27, 2003
    Publication date: February 5, 2004
    Inventors: Joseph F. Poduslo, Geoffrey L. Curran, Thomas M. Wengenack