Abstract: A process and intermediates for the enantioselective synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid are disclosed.

Abstract: It has been found that the 5' regions of RNA viruses act as enhancers of translation of mRNA. The omega prime (.OMEGA.') sequence of Tobacco Mosaic Virus, derivatives and portions thereof, and 5' leader sequences of other RNA viruses can be ligated upstream of an appropriate mRNA or used in the form of cDNA in an expression vector. The translational enhancers are effective in many different types of expression system, for example plant cells, bacteria, and animal cells, and also in in vitro translation.

Abstract: This invention relates to intermediates, and processes thereto, for the preparation of tetrahydropyrido[2,3-d]pyrimidines which are useful for the treatment of susceptable neoplasms. The intermediates have the following formula II; ##STR1## wherein the R, R.sup.1 and A groups are as defined in the specification.

Abstract: The present invention relates to an in vivo system for expression and packaging of recombinant RNA into pseudovirus particles. The invention is based on the discovery that plant viral coat proteins (CPs) may be efficiently expressed in E. coli, and that these recombinant coat proteins will function to assemble in vivo and package recombinant chimeric RNA, containing an operatively linked origin-of-assembly (OAS) sequence, to form mature viral particles containing a foreign RNA. The present invention thus provides for packaging of RNA into a ribonuclease-resistant form that is easily purified and stored, and which overcomes the prior art problems associated with degradation of RNA by ribonucleases. Significantly, the method of the invention is RNA sequence- and length-independent.

Abstract: Processes for preparing 5-substituted pyrrolo[2,3-d]pyrimidines which are useful as intermediates for the preparation of pyrrolo[2,3-d]pyrimidine antineoplastic agents or as antineoplastic agents themselves are provided.

Abstract: This invention relates to intermediates and processes thereto, for the preparation of 5,6-dihydropyrro[2,3-d]pyrimidines which are useful for the treatment of susceptible neoplasms.

Abstract: This invention provides the substantially pure (R) enantiomer of a compound of the Formula II: ##STR1## The compounds of Formula II are useful in the preparation of the substantially pure (R) enantiomer of angiotensin II antagonists of Formula III: ##STR2## wherein R.sub.1, Ar, R.sub.2 and X are variables.

Abstract: This invention provides the substantially pure (R) enantiomer of a compound of the Formula II: ##STR1## The compounds of Formula II are useful in the preparation of the substantially pure (R) enantiomer of angiotensin II antagonists of Formula III: ##STR2## wherein R.sub.1, Ar, R.sub.2 and X are variables.

Abstract: This invention relates to intermediates and processes thereto, for the preparation of 5,6-dihydropyrro[2,3-d] pyrimidines which are useful for the treatment of susceptible neoplasms.

Abstract: The present invention provides a process for preparing a 4-hydroxypyrrolo[2,3-d]pyrimidine derivative of the formula ##STR1## wherein R is NHC*H(COOR.sup.1)CH.sub.2 CH.sub.2 COOR.sup.1 or OR.sup.1 ;R.sup.1 is H or a carboxyl protecting group;the configuration about the carbon atom designated * is L;n is 0 or 1; andA is an aryl group optionally having, in addition to the COR substituent, one or two substituents selected from the group consisting of halo, hydroxy, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy; or a salt thereof, which comprises(a) halogenating a compound of the formula ##STR2## wherein R, R.sup.1, A and * are as defined above;j is 0 or 1; and(b) reacting 2,4-diamino-6-hydroxypyrimidine, or a salt thereof, with the reaction product from step (a), in the presence of a polar solvent.

Abstract: This invention relates to intermediates and processes thereto, for the preparation of 5,6-dihydropyrro[2,3-d]pyrimidines which are useful for the treatment of susceptible neoplasms

Abstract: The invention comprises a telecommunications terminal block with integral but separate test port captured cap feature as well as a method of manufacturing same in an automated fashion. The block permits the electric connection of various size gauges of wires without the severing of the smallest gauges of wire or ruining the block when initially contacting on the largest gauge wire.

Abstract: A process and intermediates for the enantioselective synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid are disclosed.

Abstract: A process and intermediates for the enantioselective synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid are disclosed.

Abstract: A process for upgrading petroleum residuums by hydrogen diluent donor visbreaking employs coking of a higher boiling fraction of the visbreaker effluent wherein the hydrogen donor is also supplied to the coker feed either by excess feed to the visbreaker or by mixing a portion with the coker feed. Controlling the quantity of hydrogen donor in the visbreaker and coker feed proportionally controls the quantity of coke produced.