Abstract: Systems and methods are disclosed which provide for a “factory-calibrated” sensor. In doing so, the systems and methods include predictive prospective modeling of sensor behavior, and also include predictive modeling of physiology. With these two correction factors, a consistent determination of sensitivity can be achieved, thus achieving factory calibration.

Abstract: The disclosure relates to nanoparticle drug conjugates (NDC) that comprise ultrasmall nanoparticles, folate receptor (FR) targeting ligands, and linker-drug conjugates, and methods of making and using them to treat cancer.

Abstract: Provided are small molecule inhibitors of the KRAS(G12D) mutant oncoprotein having the structural formula: and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: In transform coefficient coding, predetermined sets of transforms may be used. Embodiments of the present invention provide an encoder and a decoder for encoding a picture into/from a data stream using block-based prediction and block-based residual coding, the encoder and decoder supporting a set of transforms for the block-based residual coding. The encoder and decoder are configured to determine a transform candidate list of transforms for a current residual block out of the set of transforms based on a height and a width of the current residual block, and to encode/decode a prediction residual within the residual block using one selected transform out of the selectable list of transforms and selectively signal/derive the selected transform in/from the data stream.

Abstract: Embodiments of systems and methods for managing a delay of network segments in an end-to-end communication path may include determining an end-to-end time delay measurement of a communication path spanning a first communication network and a second communication network, and transmitting a message comprising the determined end-to-end time delay measurement of the communication path spanning the first communication network and the second communication network to a network element of the first communication network, wherein the message is configured to enable the network element of the first communication network to configure the first communication network to provide sufficient Quality of Service (QoS) to support an end-to-end QoS requirement based on the determined end-to-end time delay.

Abstract: Traffic signal timing plans are derived from vehicle trajectory or probe data. The probe data is collected and archived in a datastore over a sample time on the order of weeks or longer. Probe data is corrected for clock drift, geo-fence filtered to a selected intersection, and then stop line crossings in the intersection are identified and analyzed along with related data to determine the timing plans and schedule for the intersection. In this way, access to government agency timing plans is obviated so as to save time and expense.

Abstract: An example device for presenting media data includes a memory configured to store media data; and one or more processors implemented in circuitry and configured to: receive a first set of media data of a media bitstream; in response to determining that a second set of media data of the media bitstream following the first set of media data will not be received within a period of time, predictively generate replacement media data for the second set of media data using at least a subset of the first set of media data; and present the first set of media data and the replacement media data.

Abstract: Provided herein are cyclic polypeptide compounds that can, e.g., bind specifically to human proprotein convertase subtilisin/kexin type 9 (PCSK9) and optionally also inhibit interaction between human PCSK9 and human low density lipoprotein receptor (LDLR), and pharmaceutical compositions comprising one or more of these compounds. Also provided are methods of reducing LDL cholesterol level in a subject in need thereof that include administering to the subject one or more of the cyclic polypeptide compounds or a pharmaceutical composition provided herein.

Abstract: Provided are compounds of Formula (I?): or pharmaceutically acceptable salts thereof, wherein the variables in the formula are as defined herein; and methods for their use and production.

Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W1, W2, Y, Z, M, L, CY, Cz, R1, R2, R3, R4, R2a, Ry, Rz, and the subscripts m, n, q, and r are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.

Abstract: A multiview backlight, multiview display, and method of multiview backlight operation include reflective multibeam elements configured to provide emitted light having directional light beams with directions corresponding to view directions of a multiview image. The multiview backlight includes a light guide configured to guide light and an array of the reflective multibeam elements. Each reflective multibeam element includes a plurality of reflective sub-elements and is configured to reflectively scatter out a portion of the guided light as the emitted light. The multiview display includes the multiview backlight and an array of light valves to modulate the directional light beams to provide the multiview image. Each reflective sub-element protrudes from a guiding surface of the light guide by a respective protrusion distance. At least some of the protrusion distances can vary as a function of distance along a length of the light guide.

Abstract: A vehicle includes a gear shifter operable to shift a manual transmission. An actuator is connected to the shifter and actuatable to bias the shifter to at least a first or second neutral position. The vehicle further includes a controller configured to bias the shifter, via the actuator, to one of the neutral positions based on a speed of the vehicle.

Abstract: Methods and systems are provided for varying the volume of an engine intake system to increase the volumetric efficiency of the engine. In one example, a resonance system may be coupled to the engine intake system and a position of a movable element in the resonance system may be varied to vary the volume of the chamber in accordance with engine speed. The intake system provides improved volumetric efficiency for the engine.

Abstract: A vehicle includes a gear shifter operable to shift a manual transmission. An actuator is connected to the shifter and actuatable to bias the shifter to at least a first or second neutral position. The vehicle further includes a controller configured to bias the shifter, via the actuator, to one of the neutral positions based on a speed of the vehicle.

Abstract: Methods and systems are provided for varying the volume of an engine intake system to increase the volumetric efficiency of the engine. In one example, a resonance system may be coupled to the engine intake system and a position of a movable element in the resonance system may be varied to vary the volume of the chamber in accordance with engine speed. The intake system provides improved volumetric efficiency for the engine.

Abstract: A frontal structure for a motor vehicle includes a deployable air dam movable from a stowed position to one or more deployed positions., wherein the. The frontal structure is configured such that when a collision event is detected, predicted or anticipated, the deployable air dam is deployed into a first deployed position in which an edge of the deployable air dam forms the lowest point of the frontal structure and the edge also extends to a point of the frontal structure that is at least as far forward as any other part of the frontal structure of the vehicle in the same vertical plane.

Abstract: An air connector is described mountable opposite an intake or exhaust port in an associated intake or exhaust pipe of an internal combustion engine to allow the port to communicate selectively with the associated pipe and with a compressed air storage tank. The connector comprises a stopper mounted on a rod movable by an actuator between an open position in which the port communicates with the associated pipe and a closed position in which the stopper seals around the entrance of the port to isolate the port from the associated pipe. An air passage is provided in the stopper and the rod to allow communication between the port and the compressed air storage tank when the stopper is in the closed position, and a check valve is arranged in the air passage and biased in a direction to prevent escape of air from the compressed air storage tank in all positions of the stopper.

Abstract: An air connector is described mountable opposite an intake or exhaust port in an associated intake or exhaust pipe of an internal combustion engine to allow the port to communicate selectively with the associated pipe and with a compressed air storage tank. The connector comprises a stopper mounted on a rod movable by an actuator between an open position in which the port communicates with the associated pipe and a closed position in which the stopper seals around the entrance of the port to isolate the port from the associated pipe. An air passage is provided in the stopper and the rod to allow communication between the port and the compressed air storage tank when the stopper is in the closed position, and a check valve is arranged in the air passage and biased in a direction to prevent escape of air from the compressed air storage tank in all positions of the stopper.

Abstract: A method and system for stabilizing energy consumption in multiple loads, or in single multi-phase loads. The method and system also compensates for unbalance in multi-phase loads. A central controller monitors variable reactances in the loads and identifies situations of power and/or current fluctuation and/or unbalance. It determines appropriate corrective action by the other loads/phases to compensate for the power and/or current change or unbalance due to the problematic load, and it issues control signals instructing variable reactor controllers associated with the other loads to adjust accordingly. The method and system may by applied to electric arc furnace installations. An electrode position controller may be used in place of, or in conjunction with, the variable reactance control system to take corrective action to address power and/or current changes or unbalances. The system and method may be employed to maintain a predetermined level of unbalance in the system.

Abstract: A method is disclosed for operating an internal combustion engine of the type having an engine cylinder with a reciprocating piston, first and second intake ports for admitting gas from an ambient air supply into the engine cylinder, first and second intake valves each arranged between a respective one of the intake ports and the engine cylinder, a non-return valve arranged in the second of the intake ports at a distance from the second intake valve and oriented to allow gas to flow only towards the engine cylinder, and a variable valve actuating system for controlling the opening and closing of at least the second intake valve. In the method of the invention, in at least one operating mode of the engine, the second intake valve is opened and closed, while the cylinder is fully isolated from the ambient air, to permit gas transfer between the cylinder and an auxiliary chamber temporarily defined by the part of the second intake port lying between the second intake valve and the non-return valve.