Abstract: Various methods and compositions are provided which can be employed to modulate the immune system. Compositions include a fusion protein comprising: (a) a first polypeptide comprising Interleukin-2 (IL-2) or a functional variant or fragment thereof; and (b) a second polypeptide, fused in frame to the first polypeptide, wherein the second polypeptide comprises an extracellular domain of Interleukin-2 Receptor alpha (IL-2R?) or a functional variant or fragment thereof, and wherein the fusion protein has IL-2 activity. Various methods are provided for modulating the immune response in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the IL-2/IL-2R? fusion protein disclosed herein.

Abstract: Various methods and compositions are provided which can be employed to modulate the immune system. Compositions include a fusion protein comprising: (a) a first polypeptide comprising Interleukin-2 (IL-2) or a functional variant or fragment thereof; and (b) a second polypeptide, fused in frame to the first polypeptide, wherein the second polypeptide comprises an extracellular domain of Interleukin-2 Receptor alpha (IL-2R?) or a functional variant or fragment thereof, and wherein the fusion protein has IL-2 activity. Various methods are provided for modulating the immune response in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the IL-2/IL-2R? fusion protein disclosed herein.

Abstract: The invention relates to a front end of a motor vehicle, consisting of at least one main body and at least a first thermoplastic part and a second thermoplastic part, which are securely connected by injection molding firstly to the main body and simultaneously the various plastics parts are securely connected to one another, wherein the two plastics parts consist of different plastics materials and these are injection molded according to the bi-injection process and fuse with one another when they encounter one another.

Abstract: The present invention relates to a transverse-member motor-vehicle module for receiving the instrument panel and reinforcing the bodywork for the direct connection of the two A-pillars of a motor vehicle, composed of a transverse member with a steering-column retainer, where the transverse-member module, i.e. not only the transverse member but also the steering-column retainer, are manufactured using a metal-plastic-composite design (hybrid technology), and these are composed of at least one main body and of at least one first thermoplastic part and one second thermoplastic part, where these have been securely bonded via injection molding firstly to the main body and simultaneously the various plastics parts have been bonded to one another, where the two plastics parts are composed of different plastics materials and these are injected in the bi-injection molding process, where they fuse with one another when they encounter one another.

Abstract: The present invention relates to lightweight components of hybrid design, also termed hybrid component or hollow-chamber lightweight component, composed of a parent body which is composed of galvanized iron and which is reinforced by means of thermoplastics and is suitable for the transmission of high mechanical loads.

Abstract: The invention relates to a front end of a motor vehicle, consisting of at least one main body and at least a first thermoplastic part and a second thermoplastic part, which are securely connected by injection molding firstly to the main body and simultaneously the various plastics parts are securely connected to one another, wherein the two plastics parts consist of different plastics materials and these are injection molded according to the bi-injection process and fuse with one another when they encounter one another.

Abstract: The present invention relates to lightweight components of hybrid design, also termed hybrid component or hollow-chamber lightweight component, composed of a parent body which is composed of surface-pretreated aluminium and which is reinforced by means of thermoplastics and is suitable for the transmission of high mechanical loads, where particular flow aids are added to the thermoplastic in order to improve its physical properties.

Abstract: The present invention relates to a transverse-member motor-vehicle module for receiving the instrument panel and reinforcing the bodywork for the direct connection of the two A-pillars of a motor vehicle, composed of a transverse member with a steering-column retainer, where the transverse-member module, i.e. not only the transverse member but also the steering-column retainer, are manufactured using a metal-plastic-composite design (hybrid technology), and these are composed of at least one main body and of at least one first thermoplastic part and one second thermoplastic part, where these have been securely bonded via injection moulding firstly to the main body and simultaneously the various plastics parts have been bonded to one another, where the two plastics parts are composed of different plastics materials and these are injected in the bi-injection moulding process, where they fuse with one another when they encounter one another.

Abstract: The present invention relates to structural organosheet-components of hybrid design composed of an organosheet which is reinforced by means of thermoplastics and which is suitable for the transmission of high mechanical loads, where particular flow aids are added to the thermoplastic in order to improve its physical properties.

Abstract: The present invention relates to a frame side component of bodywork of a motor vehicle, preferably a car, where, respectively, a metal outer frame manufactured as a single piece and a metal inner frame manufactured as a single piece, where these respectively have at least one aperture delimited by a roof arch segment, a body-floor longitudinal-member segment and a central-column segment, are securely connected to one another, and the cavities produced between metal outer frame and metal inner frame via the connection are reinforced by reinforcement structures composed of moulded-on plastic and the reinforcement structures enter into a secure metal-plastic connection with the two frames.

Abstract: The present invention relates to lightweight components of hybrid design, also termed hybrid component or hollow-chamber lightweight component, composed of a parent body which is composed of galvanized iron and which is reinforced by means of thermoplastics and is suitable for the transmission of high mechanical loads.

Abstract: The present invention relates to lightweight components of hybrid design, also termed hybrid component or hollow-chamber lightweight component, composed of a parent body which is composed of surface-pretreated aluminium and which is reinforced by means of thermoplastics and is suitable for the transmission of high mechanical loads, where particular flow aids are added to the thermoplastic in order to improve its physical properties.

Abstract: The present invention relates to a transverse-member module for receiving the instrument panel and reinforcing the bodywork via direct connection of the two A-pillars of a motor vehicle, composed of a transverse member with a steering-column retainer, where the transverse-member module, i.e. not only the transverse member but also the steering-column retainer, are produced using a metalplastic-composite design (hybrid technology).

Abstract: The present invention relates to lightweight components of hybrid design, also termed hybrid components or hollow-chamber lightweight components, composed of a shell-type parent body which is reinforced by means of thermoplastics and is suitable for the transmission of high mechanical loads, where particular flow aids are added to the thermoplastic in order to improve its physical properties.

Abstract: The present invention relates to dismountable vehicle panelling, and in particular a system for connecting vehicle body parts and panelling sections which are used as panelling for load-bearing supporting structures of vehicles.