Abstract: A watery lotion composition for topical application to skin comprising at least one extract from the fermentation of the microorganism Bifidobacterium, at least one extract from the fermentation of the microorganism Lactobacillus, and mineral water having at least 250 ppm of total mineral dissolved solids and a method for improving the efficacy of a watery lotion and/or a second skin care product by layering the products on the skin.

Abstract: An applicator for applying cosmetic agents into human skin, comprising: (a) a base, (b) a plurality of dissolvable microneedles fixed to said base and projecting therefrom a distance sufficient to penetrate into the skin, said microneedles being made of a material that is capable of disintegration and dispersion into the skin, (c) a cosmetic agent carried by said microneedles for delivery by said microneedles into the skin, and (d) wherein said dissolvable microneedles are configured as a dissolvable exterior shell and said shell encapsulates one or more cosmetic agents.

Abstract: An applicator for applying cosmetic agents into human skin, comprising: (a) a base, (b) a plurality of microneedles fixed to said base and projecting therefrom a distance sufficient to penetrate into the skin, said microneedles being made of a material that is capable of disintegration and dispersion into the skin, and (c) a cosmetic agent carried by said microneedles for delivery by said microneedles into the skin.

Abstract: Butyric acid esters of resveratrol and topical compositions containing the esters.

Abstract: Linoleic or Linolenic acid esters of resveratrol and topical compositions containing the esters.

Abstract: The invention relates to a method for improving skin lipid barrier function by applying to the skin a composition comprising effective amounts of a protease inhibitor and a cell differentiation enhancer. The composition is useful in promoting skin lipid barrier repair and maintaining the integrity of the lipid barrier. In this regard, the compositions can be used in the treatment and prevention of dry skin, and associated chrono/proto-aging conditions, in the treatment and prevention of irritation on the skin, in the treatment and prevention of UV-related damage to the skin, and in the enhancement of the retention of self-tanning.

Abstract: Compositions and methods for enhancing repair of damaged DNA in skin cells. Topical compositions comprising at least one agent that upregulates circadian gene expression in skin cells and at least one non-circadian agent that delays mitosis in skin cells. Preferably, such compositions comprise one or more keratinocyte clock and per1 gene activators, along with SIRT1 or one or more sirt1 activators. More preferably, the sirt1 activator is a synergistic combination of specific peptidic sirt1 activators and resveratrol. Preferably, such compositions are easy to use, efficacious, cosmetically acceptable, chemically, thermodynamically and light stable, safe for topical use, have little or no side effects, and commercially feasible in a personal care marketplace.

Abstract: The present invention comprises cosmetic compositions and methods for retarding hair growth comprising a combination of an ornithine decarboxylase inhibitor, an anti-angiogenic active and an anti-inflammatory.

Abstract: Salicylic acid esters of resveratrol and topical compositions containing same.

Abstract: The invention relates to a method for improving skin lipid barrier function by applying to the skin a composition comprising effective amounts of a protease inhibitor and a cell differentiation enhancer. The composition is useful in promoting skin lipid barrier repair and maintaining the integrity of the lipid barrier. In this regard, the compositions can be used in the treatment and prevention of dry skin, and associated chrono/proto-aging conditions, in the treatment and prevention of irritation on the skin, in the treatment and prevention of UV-related damage to the skin, and in the enhancement of the retention of self-tanning.

Abstract: Ascorbic acid esters of resveratrol and topical compositions containing same.

Abstract: Ascorbic acid esters of resveratrol and topical compositions containing same.

Abstract: Salicylic acid esters of resveratrol and topical compositions containing same.

Abstract: The present invention provides a method for stimulating hair growth, which comprises applying a composition containing a combination of a creatine compound and carnitine. The composition may further comprise 5?-AMP and NADH. Such a composition is effective in stimulating cell proliferation in the hair bulb of hair plugs.

Abstract: A hair straightening topical composition comprising transglutaminase and polylysine, which act to form a surface barrier film and moisture shield around human hair. The transglutaminase also contributes to hair straightening. The composition also comprises one or more additional hair straightening agents, other than TGase, that are capable of affecting secondary, tertiary and quaternary protein structures of human hair, preferably sodium metabisulfite and/or tourmaline. The invention includes compositions that may be washed out of the hair after straightening has occurred, and compositions that are intended to remain in the hair for additional or extended benefits. The invention includes methods of using a topical composition that is capable of affecting secondary, tertiary and quaternary protein structures of human hair.

Abstract: Resveratrol ferulate compounds and compositions.

Abstract: An emulsion cosmetic composition comprising at least one resveratrol derivative, a water phase, and an oil phase containing at least one linear or branched volatile or near volatile silicone and a method for delivering active resveratrol to the skin.

Abstract: The present invention relates to methods and compositions for repairing adverse effects of the environment, daily stress, sun exposure, or pre-mature aging on human skin, comprising applying to the skin, prior to a period of bodily rest, a topical composition that contains resveratrol or a derivative thereof and at least one DNA repair enzyme.

Abstract: The present invention relates to a method of modulating a selected biological activity of a naturally occurring material having one or more biological activities in an extract of the naturally occurring material, the method comprising incubating the extract in a medium in the presence of an aerobically metabolizing microorganism, under suitable aerobic conditions, for a period of time sufficient to modulate the selected activity with respect to baseline activity of the unincubated extract. The invention also relates to the bioconverted material so prepared, and the use of same in cosmetic or pharmaceutical compositions.

Abstract: Topical compositions for reducing the appearance of fine lines and wrinkles on the skin contain one or more ion exchange polymers, in a cosmetically or pharmaceutically acceptable carrier.