Abstract: Disclosed are methods of synthesis and/or purification of certain 3,7-diamino-phenothiazin-5-ium compounds (“diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (Methylene Blue), and the resulting high purity characterized by a purity greater than 98%, and very low levels of heavy metals and organic impurities Azure A, B, C and MVB. Also disclosed are methods of treatment of a tauopathy or methemoglobinemia in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of the high-purity diaminophenothiazinium compound.

Abstract: The system is disclosed for visual marking sensitive documents for leak prevention. Each time an action is taken with regard to a document (e.g., creation, viewing, downloading), that action is added to a distributed ledger, essentially creating a unique hash for a new instance of the document. This new hash is visually embedded in the document as a code comprising a plurality of differently shaded pixels, wherein some of the pixels directly encode information regarding the document (e.g., an account that generated the new instance of the document, a date, a time, a unique ID for the document, etc.) and some of the pixels do not encode information. The code is capable of being scanned either digitally or physically on a printed version of the document, such that the immediate source of the document, corresponding to who leaked the document, is able to be discerned.

Abstract: Described are methods of preparing reduced 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of formula: wherein: R1 and R9 are independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These methods are particularly useful for producing stable reduced forms, and with high purity. The stability and purity are especially relevant for pharmaceutical compositions for the treatment of disease. The compounds are useful for treatment of e.g. tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs.

Abstract: Systems and methods for offering and purchasing tokenized securities on a blockchain platform meeting current and future federal, state, and offering and holding entity rules and regulations. Tokenized securities purchased during or after the tokenized securities offering are tradable on a secondary market. The server computer of the tokenized securities provides an automated transfer capability for tokenized securities holders.

Abstract: A motion feedthrough for a surgical drape, the motion feedthrough comprising a drive transfer element comprising a first portion and a second portion, the first portion being releasably engageable with a portion of a robot arm and the second portion being releasably engageable with a portion of an instrument, the drive transfer element being movable relative to a bulk portion of the drape so as to transfer drive between the robot arm and the instrument.

Abstract: A blade assembly includes an adapter board including a lower tool bit attachment portion, terminating in a lower adapter board free end, the lower adapter board free end defining a bottom surface defining a plurality of shank receiving bores. A plurality of bushings are disposed in a corresponding one of the plurality of shank receiving bores.

Abstract: Provided is a casing washout perforating gun assembly for use in a wellbore. The casing washout perforating gun assembly, in one example, includes a carrier gun body, an uphole plurality of charges supported within the carrier gun body, and a downhole plurality of charges supported within the carrier gun body. According to this example, the uphole plurality of charges have an uphole size or uphole explosive design to perforate uphole openings having uphole opening areas within a wellbore casing, and the downhole plurality of charges have a different downhole size or different downhole explosive design to perforate downhole openings having downhole opening areas within the wellbore casing, and furthermore the downhole opening areas are at least 20 percent less than the uphole opening areas.

Abstract: A wear member comprises a shank portion defining a longitudinal axis, a free end and a perimeter, at least one flat surface on the perimeter extending to the free end and a cross-hole defining a cross-hole axis along which the cross-hole extends through the at least one flat surface perpendicularly, and a wear portion extending downwardly axially from the shank portion, the wear portion including a polygonal configuration.

Abstract: Systems and methods for offering and purchasing tokenized securities on a blockchain platform meeting current and future federal, state, and offering and holding entity rules and regulations. Tokenized securities purchased during or after the tokenized securities offering are tradable on a secondary market. The server computer of the tokenized securities provides an automated transfer capability for tokenized securities holders.

Abstract: Systems and methods for offering and purchasing tokenized securities on a blockchain platform meeting current and future federal, state, and offering and holding entity rules and regulations. Tokenized securities purchased during or after the tokenized securities offering are tradable on a secondary market. The server computer of the tokenized securities provides an automated transfer capability for tokenized securities holders.

Abstract: Systems and methods for offering and purchasing tokenized securities on a blockchain platform meeting current and future federal, state, and offering and holding entity rules and regulations. Tokenized securities purchased during or after the tokenized securities offering are tradable on a secondary market. The server computer of the tokenized securities provides an automated transfer capability for tokenized securities holders.

Abstract: An orientation plate comprises a rectangular body defining a top surface, a bottom surface, a front surface, a back surface, a first end surface, a second end surface, and a thickness that is the minimum dimension of the body, and a plurality of apertures extending through the thickness of the body, each aperture defining a perimeter having at least one orientation flat.

Abstract: Systems and methods for displaying a virtual character in a mixed reality environment are disclosed. In some embodiments, a view of the virtual character is based on an animation rig comprising primary joints and helper joints. The animation rig may be in a pose defined by spatial relationships between the primary joints and helper joints. The virtual character may be moving in the mixed reality environment. In some instances, the virtual character may be moving based on a comparison of interestingness values associated with elements in the mixed reality environment. The spatial relationship transformation associated with the movement may be indicated by movement information. In some embodiments, the movement information is received from a neural network.

Abstract: The system is disclosed for visual marking sensitive documents for leak prevention. Each time an action is taken with regard to a document (e.g., creation, viewing, downloading), that action is added to a distributed ledger, essentially creating a unique hash for a new instance of the document. This new hash is visually embedded in the document as a code comprising a plurality of differently shaded pixels, wherein some of the pixels directly encode information regarding the document (e.g., an account that generated the new instance of the document, a date, a time, a unique ID for the document, etc.) and some of the pixels do not encode information. The code is capable of being scanned either digitally or physically on a printed version of the document, such that the immediate source of the document, corresponding to who leaked the document, is able to be discerned.

Abstract: A tool bit includes a working portion, and a shank portion defining a shank free end. The working portion includes a pair of side inserts, and a front insert.

Abstract: A retaining spring clip includes an elongated body defining a longitudinal direction, a lateral direction that is perpendicular to the longitudinal direction, and a transverse direction that is perpendicular to the lateral direction and the longitudinal direction. A handle is disposed proximate to a first longitudinal end, an intermediate spring is disposed along the longitudinal direction, and a stepped groove is disposed proximate to a second longitudinal end. A triangular shaped void forms a backside of the intermediate spring, and a void filler is disposed in the triangular shaped void.

Abstract: A spring clip defines an axis of movement, and includes a handle portion disposed at a first end along the axis of movement, and a tool bit engaging portion disposed at a second end along the axis of movement. Also, an adapter board engaging portion is disposed at least partially between the handle portion, and the tool bit engaging portion along the axis of movement.