Patents by Inventor Thomas Marsilje

Thomas Marsilje has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterotetracyclic compounds as TPO mimetics
    Patent number: 8153671
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: April 10, 2012
    Assignee: IRM LLC
    Inventors: Phillip B. Alper, Thomas Marsilje, Arnab Chatterjee, Wenshuo Lu, Daniel Mutnick, Michael Roberts, Yun He
  • Compounds and compositions as TPO mimetics
    Patent number: 7816542
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia.
    Type: Grant
    Filed: August 15, 2006
    Date of Patent: October 19, 2010
    Assignee: IRM LLC
    Inventors: Thomas Marsilje, Wenshuo Lu, Phillip B. Alper, Daniel Mutnick, Yun He
  • Immunosuppressant compounds and compositions
    Patent number: 7572811
    Abstract: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: August 11, 2009
    Assignee: IRM LLC
    Inventors: Shifeng Pan, Thomas Marsilje, Wenshuo Lu, Wenqi Gao, Nathanael Schiander Gray, Yun He, Yahua Liu, Yuan Mi, Yongping Xie
  • HETEROTETRACYCLIC COMPOUNDS AS TPO MIMETICS
    Publication number: 20090075996
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia.
    Type: Application
    Filed: July 14, 2006
    Publication date: March 19, 2009
    Applicant: Irm LLC
    Inventors: Phillip B. Alper, Thomas Marsilje, Arnab Chatterjee, Wenshuo Lu, Daniel Mutnick, Michael Roberts, Yun He
  • Compounds and Compositions as Tpo Mimetics
    Publication number: 20080194668
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia.
    Type: Application
    Filed: August 15, 2006
    Publication date: August 14, 2008
    Applicant: IRM LLC
    Inventors: Thomas Marsilje, Wenshuo Lu, Phil Alper, Daniel Mutnick, Yun He
  • Immunosuppressant Compounds and Compositions
    Publication number: 20070203100
    Abstract: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
    Type: Application
    Filed: February 24, 2005
    Publication date: August 30, 2007
    Applicant: IRM LLC
    Inventors: Shifeng Pan, Thomas Marsilje, Wenshuo Lu, Gao Wenqi, Nathanael Gray, Yun He, Yahua Liu, Yuan Mi, Yongping Xie
  • Kinase inhibitors
    Publication number: 20060089401
    Abstract: The present invention provides a method for identifying inhibitors of protein kinases. Methods are also provided for inhibiting protein kinase activity. Specific non-peptide protein tyrosine kinase inhibitors are provided. The protein kinases produced using the method of the present invention may be used to treat a number of conditions in patients, including cancer, psoriasis, atherosclerosis, or immune system activity.
    Type: Application
    Filed: October 27, 2005
    Publication date: April 27, 2006
    Inventors: David Hangauer, Thomas Marsilje, Karen Milkiewicz
  • Immunosuppressant compounds and compositions
    Publication number: 20050014724
    Abstract: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
    Type: Application
    Filed: May 19, 2004
    Publication date: January 20, 2005
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Thomas Marsilje, Nathanel Gray, Tao Jiang, Wenshuo Lu, Shifeng Pan