Patents by Inventor Thomas Martin Ramseier
Thomas Martin Ramseier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10323261Abstract: A polyhydroxyalkanoate copolymer composition is provided. The composition comprises a plurality of polyhydroxyalkanoate copolymer molecules. The polyhydroxyalkanoate copolymer molecules (i) comprise 3-hydroxybutyrate monomers and 4-hydroxybutyrate monomers, (ii) have a monomeric molar percentage of 4-hydroxybutyrate monomers of 23.5 to 75%, and (iii) have a biobased content of ?80%. Also provided is a method of making a polyhydroxyalkanoate copolymer composition. The method comprises culturing an organism in the presence of one or more carbon raw materials under conditions under which (a) the one or more carbon raw materials are converted to 3-hydroxybutyryl-CoA and 4-hydroxybutyryl-CoA and (b) the 3-hydroxybutyryl-CoA and the 4-hydroxybutyryl-CoA are polymerized to form the polyhydroxyalkanoate copolymer molecules, thereby forming the composition. The organism has been genetically engineered to comprise particular enzymatic activities, and to not comprise other particular enzymatic activities.Type: GrantFiled: October 17, 2017Date of Patent: June 18, 2019Assignee: CJ CHEILJEDANG CORPORATIONInventors: Thomas Martin Ramseier, Jeffrey A. Bickmeier, William R. Farmer, Catherine Morse, Himani Chinnapen, Oliver P. Peoples, Yossef Shabtai
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Publication number: 20180057848Abstract: A polyhydroxyalkanoate copolymer composition is provided. The composition comprises a plurality of polyhydroxyalkanoate copolymer molecules. The polyhydroxyalkanoate copolymer molecules (i) comprise 3-hydroxybutyrate monomers and 4-hydroxybutyrate monomers, (ii) have a monomeric molar percentage of 4-hydroxybutyrate monomers of 23.5 to 75%, and (iii) have a biobased content of ?80%. Also provided is a method of making a polyhydroxyalkanoate copolymer composition. The method comprises culturing an organism in the presence of one or more carbon raw materials under conditions under which (a) the one or more carbon raw materials are converted to 3-hydroxybutyryl-CoA and 4-hydroxybutyryl-CoA and (b) the 3-hydroxybutyryl-CoA and the 4-hydroxybutyryl-CoA are polymerized to form the polyhydroxyalkanoate copolymer molecules, thereby forming the composition. The organism has been genetically engineered to comprise particular enzymatic activities, and to not comprise other particular enzymatic activities.Type: ApplicationFiled: October 17, 2017Publication date: March 1, 2018Inventors: Thomas Martin Ramseier, Jeffrey A. Bickmeier, William R. Farmer, Catherine Morse, Himani Chinnapen, Oliver P. Peoples, Yossef Shabtai
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Patent number: 9663791Abstract: Disclosed are organisms genetically engineered to make useful products when grown on ethanol as a carbon source. The organisms are genetically engineered to produce various useful products such as polyhydroxyalkanoates, diols, diacids, higher alcohols, and other useful chemicals.Type: GrantFiled: April 26, 2012Date of Patent: May 30, 2017Assignee: CJ Research Center LLCInventors: Zhigang Zhang, Christopher W. J. McChalicher, Johan van Walsem, Oliver P. Peoples, Richard P. Eno, Thomas Martin Ramseier
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Patent number: 9181559Abstract: Transgenic plants, plant material, plant cells, and genetic constructs for synthesis of biopolymers, for example polyhydroxyalkanoates (“PHA”) are provided. In one embodiment, the transgenic plants synthesize polyhydroxybutyrate (“PHB”). In one embodiment the transgenic plant encodes siRNA for one or more of the genes encoding enzymes for producing PHA. In a more preferred embodiment, the siRNA expression is under the control of an inducible regulatory element. In another embodiment, the transgenic plant contains transgenes that encode expression enzymes that will degrade the polymer. In a preferred embodiment, the expression of these enzymes is under the control of a germination specific, inducible, or minimal promoter. In another embodiment, the transgenic plant contains transgenes encoding enzymes that increase carbon flow for polymer synthesis. In a preferred embodiment, these transgenes encode enzymes that increase carbon flow in the Calvin Cycle.Type: GrantFiled: September 15, 2010Date of Patent: November 10, 2015Assignee: Metabolix, Inc.Inventors: Nii Patterson, Jihong Tang, Jixiang Han, Venkata Tavva, Andrew Hertig, Zhigang Zhang, Thomas Martin Ramseier, Karen Bohmert-Tatarev, Oliver P. Peoples, Kristi D. Snell
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Publication number: 20150240273Abstract: A polyhydroxyalkanoate copolymer composition is provided. The composition comprises a plurality of polyhydroxyalkanoate copolymer molecules. The polyhydroxyalkanoate copolymer molecules (i) comprise 3-hydroxybutyrate monomers and 4-hydroxybutyrate monomers, (ii) have a monomeric molar percentage of 4-hydroxybutyrate monomers of 23.5 to 75%, and (iii) have a biobased content of ?80%. Also provided is a method of making a polyhydroxyalkanoate copolymer composition. The method comprises culturing an organism in the presence of one or more carbon raw materials under conditions under which (a) the one or more carbon raw materials are converted to 3-hydroxybutyryl-CoA and 4-hydroxybutyryl-CoA and (b) the 3-hydroxybutyryl-CoA and the 4-hydroxybutyryl-CoA are polymerized to form the polyhydroxyalkanoate copolymer molecules, thereby forming the composition. The organism has been genetically engineered to comprise particular enzymatic activities, and to not comprise other particular enzymatic activities.Type: ApplicationFiled: October 1, 2013Publication date: August 27, 2015Applicant: Metabolix, Inc.Inventors: Thomas Martin Ramseier, Jeffrey A. Bickmeier, William R. Farmer, Catherine Morse, Himani Chinnapen, Oliver P. Peoples, Yossef Shabtai
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Patent number: 9090898Abstract: Recombinant hosts for producing polyhydroxyalkanoates and methods of producing polyhydroxyalkanoates from renewable carbon substrates are provided. Certain recombinant hosts that produce 5 carbon chemicals such as 5-aminopentanoate (5AP), 5-hydroxyvalerate (5HV), glutarate, and 1,5 pentanediol (PDO) are also provided. One embodiment provides a recombinant host expressing a gene encoding a heterologous enzyme selected from the group consisting of a polyhydroxyalkanoate synthase and a 5-hydroxyvalerate-CoA (5HV-CoA) transferase, wherein the host produces a polymer containing 5-hydroxyvalerate. Preferably, the host expresses both a polyhydroxyalkanoate synthase and a 5HV-CoA transferase. The host can be prokaryotic or eukaryotic. A preferred prokaryotic host is E. coli. The polymers produced by the recombinant hosts can be homopolymers or copolymers of 5-hydroxyvalerate. A preferred copolymer is poly(3-hydroxybutyrate-co-5-hydroxyvalerate).Type: GrantFiled: December 14, 2009Date of Patent: July 28, 2015Assignee: Metabolix, Inc.Inventors: William R. Farmer, Jeff Bickmeier, Chenfeng Lu, Dong-Eun Chang, Frank Skraly, Thomas Martin Ramseier
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Publication number: 20140234944Abstract: Disclosed are organisms genetically engineered to make useful products when grown on ethanol as a carbon source. The organisms are genetically engineered to produce various useful products such as polyhydroxyalkanoates, diols, diacids, higher alcohols, and other useful chemicals.Type: ApplicationFiled: April 26, 2012Publication date: August 21, 2014Applicant: Metabolix, Inc.Inventors: Zhigang Zhang, Christopher W.J. McChalicher, Johan van Walsem, Oliver P. Peoples, Richard P. Eno, Thomas Martin Ramseier
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Patent number: 8288127Abstract: The present invention provides an improved expression system for the production of recombinant polypeptides utilizing auxotrophic selectable markers. In addition, the present invention provides improved recombinant protein production in host cells through the improved regulation of expression.Type: GrantFiled: July 30, 2009Date of Patent: October 16, 2012Assignee: Pfenex, IncInventors: Jane C. Schneider, Lawrence C. Chew, Anne Kathryn Badgley, Thomas Martin Ramseier
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Publication number: 20120180162Abstract: Transgenic plants, plant material, plant cells, and genetic constructs for synthesis of biopolymers, for example polyhydroxyalkanoates (“PHA”) are provided. In one embodiment, the transgenic plants synthesize polyhydroxybutyrate (“PHB”). In one embodiment the transgenic plant encodes siRNA for one or more of the genes encoding enzymes for producing PHA. In a more preferred embodiment, the siRNA expression is under the control of an inducible regulatory element. In another embodiment, the transgenic plant contains transgenes that encode expression enzymes that will degrade the polymer. In a preferred embodiment, the expression of these enzymes is under the control of a germination specific, inducible, or minimal promoter. In another embodiment, the transgenic plant contains transgenes encoding enzymes that increase carbon flow for polymer synthesis. In a preferred embodiment, these transgenes encode enzymes that increase carbon flow in the Calvin Cycle.Type: ApplicationFiled: September 15, 2010Publication date: July 12, 2012Applicant: METABOLIX, INC.Inventors: Nii Patterson, Jihong Tang, Jixiang Han, Venkata Tavva, Andrew Hertig, Zhigang Zhang, Thomas Martin Ramseier, Karen Bohmert-tatarev, Oliver P. peoples, Kristi D. Snell
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Patent number: 7985564Abstract: Improved methods and prokaryotic expression systems for producing recombinant proteins using Sec-system secretion signal peptides are described using Pseudomonas fluorescens Sec secretion systems. Specific novel Sec-system secretion signal peptides are described, as are fusion proteins and coding sequences for improved secretion of recombinant proteins and peptides.Type: GrantFiled: November 22, 2004Date of Patent: July 26, 2011Assignee: Pfenex, Inc.Inventors: Diane M. Retallack, Jane C. Schneider, Thomas Martin Ramseier
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Publication number: 20100168481Abstract: Recombinant hosts for producing polyhydroxyalkanoates and methods of producing polyhydroxyalkanoates from renewable carbon substrates are provided. Certain recombinant hosts that produce 5 carbon chemicals such as 5-aminopentanoate (5AP), 5-hydroxyvalerate (5HV), glutarate, and 1,5 pentanediol (PDO) are also provided. One embodiment provides a recombinant host expressing a gene encoding a heterologous enzyme selected from the group consisting of a polyhydroxyalkanoate synthase and a 5-hydroxyvalerate-CoA (5HV-CoA) transferase, wherein the host produces a polymer containing 5-hydroxyvalerate. Preferably, the host expresses both a polyhydroxyalkanoate synthase and a 5HV-CoA transferase. The host can be prokaryotic or eukaryotic. A preferred prokaryotic host is E. coli. The polymers produced by the recombinant hosts can be homopolymers or copolymers of 5-hydroxyvalerate. A preferred copolymer is poly(3-hydroxybutyrate-co-5-hydroxyvalerate).Type: ApplicationFiled: December 14, 2009Publication date: July 1, 2010Inventors: William R. Farmer, Jeff Bickmeier, Chenfeng Lu, Dong-Eun Chang, Frank Skraly, Thomas Martin Ramseier
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Publication number: 20090325230Abstract: The present invention provides an improved expression system for the production of recombinant polypeptides utilizing auxotrophic selectable markers. In addition, the present invention provides improved recombinant protein production in host cells through the improved regulation of expression.Type: ApplicationFiled: July 30, 2009Publication date: December 31, 2009Applicant: DOW GLOBAL TECHNOLOGIES INC.Inventors: Jane C. Schneider, Lawrence C. Chew, Anne Kathryn Badgley, Thomas Martin Ramseier