Patents by Inventor Thomas Mathers

Thomas Mathers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for designing and preparing vaccines comprising directed sequence polymer compositions via the directed expansion of epitopes
    Patent number: 9533037
    Abstract: The instant invention comprises a process of preparing a composition comprising directed sequence polymer (DSP) mixtures that act as epitopes and useful as vaccines, such DSP synthesized according to a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use as a vaccine, preferably for infectious agents that are immune evasive.
    Type: Grant
    Filed: October 16, 2008
    Date of Patent: January 3, 2017
    Assignee: Declion Holdings LLC
    Inventors: Dustan Bonnin, Eric Zanelli, Jeff Krieger, Thomas Mathers
  • Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders
    Patent number: 8546532
    Abstract: The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: October 1, 2013
    Assignee: Declion Pharmaceuticals, Inc.
    Inventors: Dustan Bonnin, Eric Zanelli, Thomas Mathers
  • Methods for designing and preparing vaccines comprising directed sequence polymer compositions via the directed expansion of epitopes
    Publication number: 20110129497
    Abstract: The instant invention comprises a process of preparing a composition comprising directed sequence polymer (DSP) mixtures that act as epitopes and useful as vaccines, such DSP synthesized according to a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use as a vaccine, preferably for infectious agents that are immune evasive.
    Type: Application
    Filed: October 16, 2008
    Publication date: June 2, 2011
    Applicant: Peptimmune, Inc.
    Inventors: Dustan Bonnin, Eric Zanelli, Jeff Krieger, Thomas Mathers
  • Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders
    Publication number: 20100080796
    Abstract: The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.
    Type: Application
    Filed: April 17, 2009
    Publication date: April 1, 2010
    Applicant: Peptimmune, Inc.
    Inventors: Dustan Bonnin, Eric Zanelli, Thomas Mathers