Abstract: The present invention relates to trimeprazine derivatives of formula (I) for use for treating a neuropsychiatric disorder chosen among an intellectual disability (ID), preferably fragile X syndrome (FXS), autism spectrum disorders (ASD), and attention deficit hyperactivity disorder (ADID). The invention also relates to pharmaceutical compositions for use comprising such derivatives.

Abstract: A method for the computer-aided design of an aeronautic system forming all or part of an aircraft, using a criterion of maintenance time cost over a given period of use. The cost is computed as the weighted sum of a first component representing the mean flight time lost during this period, a second component representing the mean unscheduled maintenance time for this system during said period, and a third component representing the scheduled maintenance time for this system throughout said period. The configuration corresponding to the lowest time cost is then selected.

Abstract: The invention concerns a method for the computer-aided design of an aeronautic system forming all or part of an aircraft, using a criterion of maintenance time cost over a given period of use. The cost is computed as the weighted sum (250) of a first component (220) representing the mean flight time lost during this period, of a second component (230) representing the mean unscheduled maintenance time for this system during said period, and a third component representing the scheduled maintenance time for this system throughout said period. The configuration corresponding to the lowest time cost is then selected (260).