Abstract: The present disclosure relates to methods of preventing or inhibiting fibrosis using small molecule sialidase inhibitors. The present disclosure also relates to methods treating obesity, liver inflammation, steatosis, and cancer. These methods can involve administering the compounds to a patent at risk of developing fibrosis inflammation, obesity, steatosis, or cancer, in a manner that inhibits NEU3.

Abstract: The present disclosure relates to methods of preventing or inhibiting fibrosis using small molecule sialidase inhibitors. The present disclosure also relates to methods treating obesity, liver inflammation, steatosis, and cancer. These methods can involve administering the compounds to a patent at risk of developing fibrosis inflammation, obesity, steatosis, or cancer, in a manner that inhibits NEU3.

Abstract: A low power, high redundancy point-to-point meter reading system, such as an automatic meter reading (AMR) system, that uses digital signal processing (DSP) techniques to make effective use of more (and potentially all) of the continual low-power data transmissions inherent in one-way data transmission systems by using multiple data transmissions to build a stronger, narrower band data transmission. For example, DSP techniques combining multiple low-power data samples into stronger signals can be used to lower the bandwidth required by the data collectors from the narrowband range (e.g., 30 kHz) down to the ultra-narrow frequency range (e.g., 7 kHz). Similarly, these DSP techniques may be used to increase the range of one-way meter systems in the 900 MHz ISM band. As another example, these DSP techniques may also be used to increase the sensitivity in the time domain rather than the frequency or code domain.

Abstract: A very narrowband mesh communication system utilizes single-mode transponders for “hop” communications between meters and data collection nodes, as well “mesh” relay communications between meters. The relay nodes and the data collection points may both utilize a 500 kHz communication band divided into 50 or 40 very narrowband sub-channels, which in this example are 10 kHz or 12.5 kHz wide. This increases the sensitivity of the transponders to the ?130 dBM range and low data rates in the range of hundred of bits per second, which is well suited to Narrowband Internet of Things (NB-IOT) applications. The increased transponder sensitivity also increases the ability of the mesh system to communicate with hard-to-reach transponders and opens the system to a wider range of alternative communication hop paths.

Abstract: A very narrow band multipoint communication system suitable for use in an automatic meter reading (AMR) system having a communication protocol that divides each main channel of a frequency or digital code hopping system into multiple sub-channels and applies frequency division multiplexing among the sub-channels. Each sub-channel exhibits a very narrow band characteristic that allows gain increase to increase the transmission range of the meters. In addition, frequency division multiplexing among the sub-channels greatly increases the number of meters that can communicate on each main channel. The data collection device demodulates and decodes the multiplexed meter signals at an intermediate frequency with electronic circuitry. The resulting very narrow band AMR system exhibits greater transmission range, greater bandwidth and can accommodate a much larger number of meters per data collection device in comparison to a conventional narrow band AMR system.

Abstract: A very narrow band multipoint communication system suitable for use in an automatic meter reading (AMR) system having a communication protocol that divides each main channel of a frequency or digital code hopping system into multiple sub-channels and applies frequency division multiplexing among the sub-channels. Each sub-channel exhibits a very narrow band characteristic that allows gain increase to increases the transmission range of the meters. In addition, frequency division multiplexing among the sub-channels greatly increases the number of meters that can communicate on each main channel. The data collection device demodulates and decodes the multiplexed meter signals at an intermediate frequency with electronic circuitry. The resulting very narrow band AMR system exhibits greater transmission range, greater bandwidth and can accommodate a much larger number of meters per data collection device in comparison to conventional narrow band AMR system.

Abstract: An apparatus and method are disclosed in which ultrasonic vibration is used to assist the degassing of molten metals or metal alloys thereby reducing gas content in the molten metals or alloys. High-intensity ultrasonic vibration is applied to a radiator that creates cavitation bubbles, induces acoustic streaming in the melt, and breaks up purge gas (e.g., argon or nitrogen) which is intentionally introduced in a small amount into the melt in order to collect the cavitation bubbles and to make the cavitation bubbles survive in the melt. The molten metal or alloy in one version of the invention is an aluminum alloy. The ultrasonic vibrations create cavitation bubbles and break up the large purge gas bubbles into small bubbles and disperse the bubbles in the molten metal or alloy more uniformly, resulting in a fast and clean degassing.

Abstract: Methods for site-specific modification of protein are provided. These methods modify proteins which have been labeled at a particular site by the reaction of a transglutaminase with a glutamine peptide sequence which has been engineered into the protein. The site-specific modification methods of the invention are useful for producing reagents useful in high throughput screening methods and in producing protein delivery vehicles for specifically targeting cellular and non-cellular targets. Also described are improved biotinylation reagents.

Abstract: A method of forming a material includes the steps of: vibrating a molten material at an ultrasonic frequency while cooling the material to a semi-solid state to form non-dendritic grains therein; forming the semi-solid material into a desired shape; and cooling the material to a solid state. The method makes semi-solid castings directly from molten materials (usually a metal), produces grain size usually in the range of smaller than 50 ?m, and can be easily retrofitted into existing conventional forming machine.

Abstract: Prokaryotic FAB G polypeptides and DNA (RNA) encoding such FAB G and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FAB G for the treatment of infection, such as bacterial infections. Antagonists against such FAB G and their use as a therapeutic to treat infections, such as staphylococcal infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FAB G nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding FAB G and for detecting the polypeptide in a host.

Abstract: A method of forming a material includes the steps of: vibrating a molten material at an ultrasonic frequency while cooling the material to a semi-solid state to form non-dendritic grains therein; forming the semi-solid material into a desired shape; and cooling the material to a solid state. The method makes semi-solid castings directly from molten materials (usually a metal), produces grain size usually in the range of smaller than 50 ?m, and can be easily retrofitted into existing conventional forming machine.

Abstract: Methods for site-specific modification of protein are provided. These methods modify proteins which have been labeled at a particular site by the reaction of a transglutaminase with a glutamine peptide sequence which has been engineered into the protein. The site-specific modification methods of the invention are useful for producing reagents useful in high throughput screening methods and in producing protein delivery vehicles for specifically targeting cellular and non-cellular targets. Also described are improved biotinylation reagents.

Abstract: Prokaryotic FAB G polypeptides and DNA (RNA) encoding such FAB G and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FAB G for the treatment of infection, such as bacterial infections. Antagonists against such FAB G and their use as a therapeutic to treat infections, such as staphylococcal infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FAB G nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding FAB G and for detecting the polypeptide in a host.

Abstract: A record and playback apparatus for use with magnetic tape cassettes and the like can be switched between the normal two track cassette format for either record or playback or single track format for either record or playback. The apparatus provides optimum record and bias signals to the record head gaps being used regardless of whether two record head gaps are used for standard format or a single record head gap is used for single track format. The apparatus also preferably includes motor speed switching and regulating circuitry so that the apparatus can be satisfactorily operated at normal cassette speed or at a reduced speed, preferably one quarter that of normal speed. Switching of play and record equalization as well as record bias is also preferably included with the speed switching.