Patents by Inventor Thomas Meitinger
Thomas Meitinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9546994Abstract: The present invention relates to a method of identifying a predisposition for developing type 2 diabetes mellitus in a subject, said method comprising the step of assessing in a sample obtained from said subject the amount of one or more metabolite(s) selected from (a) a first group comprising the metabolites glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2, phosphatidylcholine acyl-alkyl C36:3 and isobaric metabolites having the same molecular mass as glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2 or phosphatidylcholine acyl-alkyl C36:3 but different chemical formula; and/or (b) a second group comprising the metabolite acetylcarnitine C2 and an isobaric mType: GrantFiled: August 13, 2013Date of Patent: January 17, 2017Assignees: Helmholtz Zentrum Munchen-Deutsches Forschungszentrum fur Geseundheit und Umwelt (GmbH), Deutsche Diabetes-Forschungsgesellschaft e.V.—Trager des Deutschen Diabetes-Zentrums Dusseldorf, Eberhard Karls Universitat Tubingen, Medizinische FakultatInventors: Wolfgang Rathmann, Christian Herder, Thomas Illig, Jerzy Adamski, Rui Wang-Sattler, Zhongao Yu, H.-Erich Wichmann, Hans-Ulrich Haring, Michael Roden, Annette Peters, Christine Meisinger, Martin Hrabe De Angelis, Thomas Meitinger
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Publication number: 20150204839Abstract: The present invention relates to a method of identifying a predisposition for developing type 2 diabetes mellitus in a subject, said method comprising the step of assessing in a sample obtained from said subject the amount of one or more metabolite(s) selected from (a) a first group comprising the metabolites glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2, phosphatidylcholine acyl-alkyl C36:3 and isobaric metabolites having the same molecular mass as glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2 or phosphatidylcholine acyl-alkyl C36:3 but different chemical formula; and/or (b) a second group comprising the metabolite acetylcarnitine C2 and an isobaric mType: ApplicationFiled: August 13, 2013Publication date: July 23, 2015Applicant: Helmholtz Zentrum MunchenInventors: Wolfgang Rathmann, Christian Herder, Thomas Illig, Jerzy Adamski, Rui Wang-Sattler, Zhongao Yu, H.-Erich Wichmann, Hans-Ulrich Haring, Michael Roden, Annette Peters, Christine Meisinger, Martin Hrabe De Angelis, Thomas Meitinger
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Patent number: 8586317Abstract: The present invention relates to methods of diagnosing hypophosphatemic disorders.Type: GrantFiled: April 11, 2011Date of Patent: November 19, 2013Assignees: Advanced Research & Technology Institute, Ludwig-Maximilians-Universitat Munchen Abeteilung Mediziniche GenetikInventors: Michael Econs, Kenneth E. White, Tim Matthias Strom, Thomas Meitinger
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Patent number: 8409809Abstract: The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.Type: GrantFiled: August 26, 2011Date of Patent: April 2, 2013Assignees: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Eberhard-Karls-Universitaet Tuebingen, Mayo Foundation For Medical Education and ResearchInventors: Thomas Meitinger, Tim Matthias Strom, Saskia Biskup, Marius Ueffing, Elisabeth Kremmer, Christian Johannes Gloeckner, Thomas Gasser, Petra Herzig, Friedrich Asmus, Nadja Patenge, Alexander Zimprich, Matthew J. Farrer, Jennifer M. Kachergus, Sara J. Lincoln, Mary M. Hulihan, Zibigniew Wszolek, Ryan Uitti
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Publication number: 20120064544Abstract: The present invention relates to methods of diagnosing hypophosphatemic disorders.Type: ApplicationFiled: April 11, 2011Publication date: March 15, 2012Inventors: Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger
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Publication number: 20120035072Abstract: The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.Type: ApplicationFiled: August 26, 2011Publication date: February 9, 2012Applicants: Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH, Mayo Foundation for Medical Education and Research, Eberhard Karls Universitaet TuebingenInventors: Thomas Meitinger, Tim Matthias Strom, Saskia Biskup, Marius Ueffing, Elisabeth Kremmer, Christian Johannes Gloeckner, Thomas Gasser, Petra (Leitner) Herzig, Friedrich Asmus, Nadja Patenge, Alexander Zimprich, Matthew J. Farrer, Jennifer M. Kachergus, Sara J. Lincoln, Mary M. Hulihan, Zibigniew Wszolek, Ryan Uitti
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Patent number: 8029986Abstract: The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.Type: GrantFiled: September 27, 2005Date of Patent: October 4, 2011Assignees: Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt(GmbH), Eberhard Karls Universitaet Tuebingen, Mayo Foundation for Medical Education and ResearchInventors: Thomas Meitinger, Tim Matthias Strom, Saskia Biskup, Marius Ueffing, Elisabeth Kremmer, Christian Johannes Gloeckner, Thomas Gasser, Petra Herzig, Friedrich Asmus, Nadja Patenge, Alexander Zimprich, Matthew J. Farrer, Jennifer M. Kachergus, Sara J. Lincoln, Mary M. Hulihan, Zibigniew Wszolek, Ryan Uitti
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Patent number: 7947810Abstract: The present invention relates to a kit for diagnosing a disorder comprising a reagent that detects FGF23 polypeptides and mutant FGF23 polypeptides.Type: GrantFiled: November 7, 2007Date of Patent: May 24, 2011Assignees: Advanced Research & Technology Institute, Ludwig-Maximilians-Universitat Munchen Abeteilung Mediziniche GenetikInventors: Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger
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Publication number: 20100235933Abstract: The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.Type: ApplicationFiled: September 27, 2005Publication date: September 16, 2010Applicants: Mayo Clinic, GSF Forschungszentrum fuer umwelt und Gesundheit GmbH, Eberhard Karls Universitaet TuebingenInventors: Thomas Meitinger, Tim Matthias Strom, Saskia Biskup, Marius Ueffing, Elisabeth Kremmer, Christian Gloeckner, Thomas Gasser, Petra Leitner, Friedrich Asmus, Nadja Patenge, Alexander Zimprich, Matthew J. Farrer, Jennifer M. Kachergus, Sara J. Lincoln, Mary M. Hulihan, Zibigniew Wszolek, Ryan Uitti
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Patent number: 7745406Abstract: The present invention relates to a kit for diagnosing a disorder comprising a reagent that detects FGF23 polypeptides and mutant FGF23 polypeptides.Type: GrantFiled: November 7, 2007Date of Patent: June 29, 2010Assignees: Advanced Research & Technology Institute, Ludwig-Maximilians-Universitat Munchen Abteilung Medizinische GenetikInventors: Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger
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Publication number: 20090311792Abstract: The present invention relates to a kit for diagnosing a disorder comprising a reagent that detects FGF23 polypeptides and mutant FGF23 polypeptides.Type: ApplicationFiled: November 7, 2007Publication date: December 17, 2009Inventors: Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger
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Patent number: 7607669Abstract: A split electromechanical motor vehicle stabilizer having a locking device, and a method for roll stabilization are described. A split motor vehicle stabilizer is provided for roll stabilization, having a built-in electromechanical actuator for bracing two stabilizer parts against one another, including at least an electric motor, a gear unit, and a locking device which can lock a housing for the actuator to a rotor in the electric motor. The housing is connected to one of the stabilizer parts, and a gear unit output shaft is connected to the other stabilizer part for the purpose of transmitting torque. The housing and the rotor can be locked in only one position relative to one another after the locking device is activated, and that is the normal position for the two halves of the stabilizer in which they are not braced against one another.Type: GrantFiled: September 21, 2007Date of Patent: October 27, 2009Assignee: Bayerische Motoren Werke AktiengesellschaftInventors: Timo Anderten, Thomas Meitinger
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Publication number: 20080241946Abstract: The present invention relates to a kit for diagnosing a disorder comprising a reagent that detects FGF23 polypeptides and mutant FGF23 polypeptides.Type: ApplicationFiled: November 7, 2007Publication date: October 2, 2008Inventors: Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger
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Publication number: 20080007023Abstract: A split electromechanical motor vehicle stabilizer having a locking device, and a method for roll stabilization are described. A split motor vehicle stabilizer is provided for roll stabilization, having a built-in electromechanical actuator for bracing two stabilizer parts against one another, including at least an electric motor, a gear unit, and a locking device which can lock a housing for the actuator to a rotor in the electric motor. The housing is connected to one of the stabilizer parts, and a gear unit output shaft is connected to the other stabilizer part for the purpose of transmitting torque. The housing and the rotor can be locked in only one position relative to one another after the locking device is activated, and that is the normal position for the two halves of the stabilizer in which they are not braced against one another.Type: ApplicationFiled: September 21, 2007Publication date: January 10, 2008Applicant: Bayerische Motoren Werke AktiengesellschaftInventors: Timo Anderten, Thomas Meitinger
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Patent number: 7314618Abstract: The present invention relates to antibodies that bind to FGF23 polypeptides and to FGF23 mutant polypeptides.Type: GrantFiled: March 4, 2003Date of Patent: January 1, 2008Assignees: Advanced Research and Technology Institute, Ludwig-Maximilians-Universtat MunchenInventors: Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger
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Patent number: 7223563Abstract: The invention relates to novel nucleic acids encoding a fibroblast growth factor-23(FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hypophosphatemic and hyperphosphatemic disorders comprising inhibiting or stimulating, respectively, the biological activity of FGF23 in a patient. The invention also relates to methods of treating osteoporosis, dermatomyositis, and coronary artery disease comprising stimulating the biological activity of FGF23 in a patient.Type: GrantFiled: July 10, 2001Date of Patent: May 29, 2007Assignees: Advanced Research and Technology Institute, Ludwig-Maximilians-Universitat MuchenInventors: Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger
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Publication number: 20030181379Abstract: The invention relates to novel nucleic acids encoding a fibroblast growth factor-23(FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hypophosphatemic and hyperphosphatemic disorders comprising inhibiting or stimulating, respectively, the biological activity of FGF23 in a patient. The invention also relates to methods of treating osteoporosis, dermatomyositis, and coronary artery disease comprising stimulating the biological activity of FGF23 in a patient.Type: ApplicationFiled: March 4, 2003Publication date: September 25, 2003Applicant: Advanced Research & Technology Institute and Ludwig-Maximilians-Universitat MunchenInventors: Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger
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Publication number: 20020156001Abstract: The invention relates to novel nucleic acids encoding a fibroblast growth factor-23(FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hypophosphatemic and hyperphosphatemic disorders comprising inhibiting or stimulating, respectively, the biological activity of FGF23 in a patient. The invention also relates to methods of treating osteoporosis, dermatomyositis, and coronary artery disease comprising stimulating the biological activity of FGF23 in a patient.Type: ApplicationFiled: July 10, 2001Publication date: October 24, 2002Applicant: Advanced Research & Technology Institute and Ludwig-Maximilians-Universitat MunchenInventors: Michael Econs, Ken White, Tim Matthias Strom, Thomas Meitinger