Abstract: Described herein are formulations of cell culture media and supplements that are stable when stored at room temperature. Embodiments described herein encompass dry granulated or agglomerated cell culture media with carbohydrate sources and vitamins that are physically separated. Further embodiments described herein are dry granulated or agglomerated cell culture media with a carbohydrate source that is separately agglomerated or powdered. Additional embodiments are dry granulated or agglomerated cell culture media with a carbohydrate source that is separately agglomerated or powdered and optionally contains vitamins. In another embodiment, the culture media or supplement is a dry granulated or agglomerated cell culture media containing granulated or agglomerated or powdered carbohydrates and vitamins in one or more of a liquid-, powdered-, granulated-, agglomerated-, coated-, or encapsulated-form.