Abstract: The present disclosure provides compositions and methods for use in vaccines, comprising polynucleotides encoding one or more viral antigen proteins and an enhancer protein, wherein the enhancer protein is a picornavirus leader (L) or a functional variant thereof. The compositions and methods provided herein may improve the production of functional viral-like particles (VLP).

Abstract: The present disclosure provides methods and compositions for the improved expression of target proteins via the co-expression of an enhancer protein in a subject. Provided herein are methods for expressing a target protein in a subject comprising administering a vector system of one or more polynucleotides encoding a target protein and an enhancer protein, wherein the polynucleotides are operatively linked, and wherein the enhancer protein is an inhibitor of nucleocytoplasmic transport (NCT) and/or the enhancer protein is selected from the group consisting of a picornavirus leader (L) protein, a picornavirus 2A protease, a rhinovirus 3C protease, a herpes simplex virus (HSV) ICP27 protein, and a rhabdovirus matrix (M) protein.

Abstract: A bicycle crank with a core comprised of a durofoam substance, a fiber-reinforced plastic coating encasing the core, a bottom bracket axle fitting arrangement foamed into the core accessible through the fiber-reinforced plastic coating, and a bottom bracket axle fitting arrangement foamed into the core accessible through the fiber-reinforced plastic coating.

Abstract: There is disclosed a havelock or neck shield attachment for a baseball type cap having a hemispheric opening and adjustment strap at the rear thereof and bill in the front, the attachment includes a securement loop portion for securing the attachment to the adjustment strap of the cap. A connector portion has first and second ends and diverging side edges between the first and second ends, the first end being secured to said securement loop forming portion and a deployable neck shield portion connected to the second end of the connector portion. The connector portion is shaped such that when stowed inside the cap, the connector portion fills the hemispheric opening and when deployed the connector portion positions the deployable neck shield in position to protect the user's neck from sun rays. The inside surface of the connector portion can carry decorative surface ornamentation (which can be a team logo) and when in a stowed position, the decorative surface ornamentation is presented for viewing.