Patents by Inventor Thomas Metzler
Thomas Metzler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10852830Abstract: In an embodiment, a method comprises: receiving, by a mechanical offset controller, input data; detecting, by the mechanical offset controller, a waveform command in the input data; responsive to the detecting, generating, by the mechanical offset controller, an unparking command; receiving, by a closed-loop controller, the unparking command; and moving, by the closed-loop controller, a mass in a haptic module from a mechanical resting position to a sensor reference position in accordance with the unparking command. The method further comprises: detecting, by the mechanical offset controller, that the input data does not include the waveform command; responsive to the detecting, generating, by the mechanical offset controller, a parking command; receiving, by a closed-loop controller, the parking command; and moving, by the closed-loop controller, the mass in the haptic module from the sensor reference position to the mechanical resting position in accordance with the parking command.Type: GrantFiled: September 11, 2018Date of Patent: December 1, 2020Assignee: Apple Inc.Inventors: Jonathan A. Gordon, Matthew Thomas Metzler, Adam I. Papamarcos, Michael Yiu Ka Diu
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Publication number: 20200081537Abstract: In an embodiment, a method comprises: receiving, by a mechanical offset controller, input data; detecting, by the mechanical offset controller, a waveform command in the input data; responsive to the detecting, generating, by the mechanical offset controller, an unparking command; receiving, by a closed-loop controller, the unparking command; and moving, by the closed-loop controller, a mass in a haptic module from a mechanical resting position to a sensor reference position in accordance with the unparking command. The method further comprises: detecting, by the mechanical offset controller, that the input data does not include the waveform command; responsive to the detecting, generating, by the mechanical offset controller, a parking command; receiving, by a closed-loop controller, the parking command; and moving, by the closed-loop controller, the mass in the haptic module from the sensor reference position to the mechanical resting position in accordance with the parking command.Type: ApplicationFiled: September 11, 2018Publication date: March 12, 2020Applicant: Apple Inc.Inventors: Jonathan A. Gordon, Matthew Thomas Metzler, Adam I. Papamarcos, Michael Yiu Ka Diu
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Patent number: 9631233Abstract: The present invention provides methods to obtain dry compositions of reaction compounds that maintain the biological activity of the compounds upon re-solubilization after a certain storage time. Preferably, the dry composition comprises a polymerase, and the dry composition is usable for polymerase chain reaction (PCR) amplification after re-solubilization.Type: GrantFiled: September 16, 2015Date of Patent: April 25, 2017Assignee: Roche Diagnostics Operations, Inc.Inventors: Thomas Metzler, Tobias Haslinger, Annette Peceny, Harald Sobek
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Publication number: 20160237473Abstract: The present invention provides methods to obtain dry compositions of reaction compounds that maintain the biological activity of the compounds upon re-solubilization after a certain storage time. Preferably, the dry composition comprises a polymerase, and the dry composition is usable for polymerase chain reaction (PCR) amplification after re-solubilization.Type: ApplicationFiled: September 16, 2015Publication date: August 18, 2016Inventors: Thomas Metzler, Tobias Haslinger, Annette Peceny, Harald Sobek
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Patent number: 9163286Abstract: The present invention provides methods to obtain dry compositions of reaction compounds that maintain the biological activity of the compounds upon re-solubilization after a certain storage time. Preferably, the dry composition comprises a polymerase, and the dry composition is usable for polymerase chain reaction (PCR) amplification after re-solubilization.Type: GrantFiled: January 31, 2014Date of Patent: October 20, 2015Assignee: Roche Diagnostics Operations, Inc.Inventors: Thomas Metzler, Tobias Haslinger, Annette Peceny, Harald Sobek
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Publication number: 20140162267Abstract: The present invention provides methods to obtain dry compositions of reaction compounds that maintain the biological activity of the compounds upon re-solubilization after a certain storage time. Preferably, the dry composition comprises a polymerase, and the dry composition is usable for polymerase chain reaction (PCR) amplification after re-solubilization.Type: ApplicationFiled: January 31, 2014Publication date: June 12, 2014Applicant: Roche Molecular Systems, Inc.Inventors: Thomas Metzler, Tobias Haslinger, Annette Peceny, Harald Sobek
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Patent number: 8652811Abstract: The present invention provides methods to obtain dry compositions of reaction compounds that maintain the biological activity of the compounds upon re-solubilization after a certain storage time. Preferably, the dry composition comprises a polymerase, and the dry composition is usable for polymerase chain reaction (PCR) amplification after re-solubilization.Type: GrantFiled: December 18, 2009Date of Patent: February 18, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Thomas Metzler, Tobias Haslinger, Annette Peceny, Harald Sobek
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Patent number: 7863015Abstract: Device, method and kit for carrying out biochemical reactions, in particular for cell-free polypeptide biosynthesis composed of an external housing which encloses an inner housing with incorporated wells and a supply chamber, wherein the wells of the inner housing each contain a producing system during the biochemical reaction, the supply chamber contains a supply liquid during the biochemical reaction and the wells of the inner housing and the supply chamber are separated by a semipermeable membrane characterized in that the inner housing has at least two wells the lower ends of which are closed by a semipermeable membrane and the upper ends of which protrude from the supply liquid contained in the supply chamber, and is connected to means for moving and incubating the producing systems and to the supply liquid.Type: GrantFiled: September 12, 2005Date of Patent: January 4, 2011Assignee: Roche Diagnostics GmbHInventors: Thomas Metzler, Hans Schels, Rolf Reichhuber, Jochen Kluge
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Publication number: 20100159529Abstract: The present invention provides methods to obtain dry compositions of reaction compounds that maintain the biological activity of the compounds upon re-solubilization after a certain storage time. Preferably, the dry composition comprises a polymerase, and the dry composition is usable for polymerase chain reaction (PCR) amplification after re-solubilization.Type: ApplicationFiled: December 18, 2009Publication date: June 24, 2010Inventors: Thomas Metzler, Tobias Haslinger, Annette Peceny, Harald Sobek
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Patent number: 7011958Abstract: The present invention concerns a method for improving the stability of linear short DNA towards exonucleases in cell-free in vitro transcription/translation systems using lysates containing exonucleases or in cellular systems containing exonucleases, wherein the stability of the linear short DNA is improved by adding unspecific linear DNA.Type: GrantFiled: April 17, 2002Date of Patent: March 14, 2006Assignee: Roche Diagnostics Operations, Inc.Inventors: Manfred Watzele, Thomas Hoffmann, Cordula Nemetz, Dieter Heindl, Thomas Metzler, Wolfgang Mutter
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Publication number: 20060008899Abstract: Device, method and kit for carrying out biochemical reactions, in particular for cell-free polypeptide biosynthesis composed of an external housing which encloses an inner housing with incorporated wells and a supply chamber, wherein the wells of the inner housing each contain a producing system during the biochemical reaction, the supply chamber contains a supply liquid during the biochemical reaction and the wells of the inner housing and the supply chamber are separated by a semipermeable membrane characterized in that the inner housing has at least two wells the lower ends of which are closed by a semipermeable membrane and the upper ends of which protrude from the supply liquid contained in the supply chamber, and is connected to means for moving and incubating the producing systems and to the supply liquid.Type: ApplicationFiled: September 13, 2005Publication date: January 12, 2006Inventors: Thomas Metzler, Hans Schels, Rolf Reichhuber, Jochen Kluge
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Publication number: 20040259081Abstract: The present invention concerns a method for protein expression comprising the steps of transcribing stabilized linear short DNA in cell-free in vitro transcription/translation systems with exonuclease-containing lysates or in a cellular system containing exonucleases and subsequent translation, wherein the stability of the linear short DNA is improved by one or several of the following measures to protect the double-stranded DNA from exonucleases:Type: ApplicationFiled: April 17, 2002Publication date: December 23, 2004Inventors: Manfred Watzele, Thomas Hoffmann, Cordula Nemetz, Dieter Heindl, Thomas Metzler, Wolfgang Mutter
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Publication number: 20040115760Abstract: Device, method and kit for carrying out biochemical reactions, in particular for cell-free polypeptide biosynthesis composed of an external housing which encloses an inner housing with incorporated wells and a supply chamber, wherein the wells of the inner housing each contain a producing system during the biochemical reaction, the supply chamber contains a supply liquid during the biochemical reaction and the wells of the inner housing and the supply chamber are separated by a semipermeable membrane characterized in that the inner housing has at least two wells the lower ends of which are closed by a semipermeable membrane and the upper ends of which protrude from the supply liquid contained in the supply chamber, and is connected to means for moving and incubating the producing systems and to the supply liquid.Type: ApplicationFiled: November 25, 2003Publication date: June 17, 2004Inventors: Thomas Metzler, Hans Schels, Rolf Reichhuber, Jochen Kluge
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Publication number: 20030073201Abstract: The present invention concerns a method for improving the stability of linear short DNA towards exonucleases in cell-free in vitro transcription/translation systems using lysates containing exonucleases or in cellular systems containing exonucleases, wherein the stability of the linear short DNA is improved by adding unspecific linear DNA.Type: ApplicationFiled: April 17, 2002Publication date: April 17, 2003Inventors: Manfred Watzele, Thomas Hoffmann, Cordula Nemetz, Dieter Heindl, Thomas Metzler, Wolfgang Mutter
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Patent number: 6162633Abstract: The subject matter of the invention concerns three cosmid vectors which are suitable for fragment cloning of a size between 7 and 36 kb. These vectors consist of an E. coli ColE1 replica, an ampicillin resistance gene, a multiple cloning cassette, cos sites for in vitro packaging with the lambda packaging extracts as well as fragments from the genome of the bacteriophage lambda. The lambda sequences were selected in a way to prevent lytic processes, vector instabilities (deletions) and unwanted recombination events between lambda DNA and the fragment to be cloned. Depending on the length of the lambda fragment inserted in the corresponding vector heterologous fragments of different lengths can be cloned.Type: GrantFiled: November 17, 1998Date of Patent: December 19, 2000Inventors: Thomas Metzler, Harald Sobek, Rolf Reichhuber
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Patent number: 5408241Abstract: An apparatus and method for tuning a multi-radiating element embedded microstrip antenna is disclosed. In one embodiment, the lower resonant frequency of an antenna is tuned using trimmable tabs integral with an upper radiating element and/or scrapable recessed edges on the ground plane surrounding the upper element and/or trimmable tabs interconnected with the ground means and extending inwardly towards the upper element.Type: GrantFiled: August 20, 1993Date of Patent: April 18, 1995Assignee: Ball CorporationInventors: Murray G. Shattuck, Jr., Frank B. Bilek, Thomas A. Metzler
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Patent number: 5153600Abstract: A multiple-frequency stacked microstrip patch antenna structure is disclosed which provides substantially increased isolation between the multiple radiating elements and between the multiple feed elements. In one embodiment of the present invention having two radiating elements, such isolation is afforded by disposing shielding around a portion of the feed pin connected to the upper radiating element by electrically connecting the reference surface with the lower radiating element. Additional isolation and improved response characteristics can be provided by employing a tuning network for each radiating element. Additionally, two or more sets of stacked radiating elements can be arranged in an array to provide increased gain or directivity capabilities.Type: GrantFiled: July 1, 1991Date of Patent: October 6, 1992Assignee: Ball CorporationInventors: Thomas A. Metzler, Richard C. Hall, Jan M. McKinnis
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Patent number: 4233607Abstract: Method and apparatus for improving the r.f. isolation between a transmitting and receiving antenna disposed at respectively corresponding spaced apart but relatively adjacent locations. A special compensation radiator is provided at the transmitting and/or receiving antenna site and fed from the same r.f. input/output which feeds the main antenna. The direction, magnitude and phase of r.f. energy radiated and/or received from the compensating radiator are chosen so as to substantially cancel the undesirable r.f. energy otherwise directly received by the receiving antenna from the transmitting antenna.Type: GrantFiled: October 28, 1977Date of Patent: November 11, 1980Assignee: Ball CorporationInventors: Gary G. Sanford, Robert E. Munson, Thomas A. Metzler