Abstract: The present invention relates to a multiple valve single port manifold for use with a multiple lumen catheter. The inventive manifolds comprise a conduit with an entry port; a plurality of means for connecting the conduit to a plurality of catheter lumens, such that each lumen is capable of being in fluid communication with the entry port; and a plurality of means for controlling access from the conduit to the plurality of catheter lumens, such that each controlling means independently regulates access from the conduit to its corresponding catheter lumen. Because each catheter lumen is independently accessible from the same manifold port, the inventive devices are useful in any medical context where a need exists to independently control access to spatially proximal sites within a patient's passageway.