Patents by Inventor Thomas Michael Hiller

Thomas Michael Hiller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250108008
    Abstract: The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.
    Type: Application
    Filed: July 2, 2024
    Publication date: April 3, 2025
    Inventors: Heinrich Haas, Sebastian Hörner, Isaac Hernan Esparza Borquez, Thomas Michael Hiller, Ferdia Bates
  • Publication number: 20240269321
    Abstract: The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.
    Type: Application
    Filed: September 30, 2021
    Publication date: August 15, 2024
    Inventors: Heinrich HAAS, Sebastian HÖRNER, Thomas Michael HILLER, Tobias KIND, Tijana BACIC
  • Patent number: 12059498
    Abstract: The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.
    Type: Grant
    Filed: February 8, 2021
    Date of Patent: August 13, 2024
    Assignee: BioNTech SE
    Inventors: Heinrich Haas, Sebastian Hörner, Isaac Hernan Esparza Borquez, Thomas Michael Hiller, Ferdia Bates
  • Patent number: 11395799
    Abstract: The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: July 26, 2022
    Assignee: BioNTech SE
    Inventors: Heinrich Haas, Sebastian Hörner, Isaac Hernan Esparza Borquez, Thomas Michael Hiller, Ferdia Bates
  • Publication number: 20220143069
    Abstract: The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.
    Type: Application
    Filed: April 1, 2020
    Publication date: May 12, 2022
    Inventors: Heinrich HAAS, Sebastian HÖRNER, Thomas Michael HILLER
  • Publication number: 20210161818
    Abstract: The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.
    Type: Application
    Filed: February 8, 2021
    Publication date: June 3, 2021
    Inventors: Heinrich Haas, Sebastian Hörner, Isaac Hernan Esparza Borquez, Thomas Michael Hiller, Ferdia Bates
  • Publication number: 20200246267
    Abstract: The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.
    Type: Application
    Filed: October 18, 2018
    Publication date: August 6, 2020
    Inventors: Heinrich Haas, Sebastian Hörner, Isaac Hernan Esparza Borquez, Thomas Michael Hiller, Ferdia Bates