Abstract: The disclosure provides process developments and novel routes for the preparation of the NK-1 receptor antagonist, Compound (I) and intermediates in those routes.

Abstract: The present invention provides processes and intermediates for the preparation of {1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile: (I)

Abstract: The disclosure provides process developments and novel routes for the preparation of the NK-1 receptor antagonist, Compound (I) and intermediates in those routes.

Abstract: The present invention provides processes and intermediates for the preparation of {1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile: (I)

Abstract: An automatic engine driven pump (EDP) depressurization system for an aircraft is disclosed. The aircraft includes at least two EDPs driven by a main engine for converting mechanical power provided by the main engine into hydraulic power for distribution by a hydraulic system. The EDP depressurization system includes a depressurization device corresponding to each of the at least two EDPs and a control module. The depressurization devices are each energized to depressurize a respective EDP. The control module is in signal communication with each of the depressurization devices. The control module includes control logic for automatically generating a depressurization signal that energizes one of the depressurization devices based on a plurality of operational conditions of the aircraft.

Abstract: An automatic engine driven pump (EDP) depressurization system for an aircraft is disclosed. The aircraft includes at least two EDPs driven by a main engine for converting mechanical power provided by the main engine into hydraulic power for distribution by a hydraulic system. The EDP depressurization system includes a depressurization device corresponding to each of the at least two EDPs and a control module. The depressurization devices are each energized to depressurize a respective EDP. The control module is in signal communication with each of the depressurization devices. The control module includes control logic for automatically generating a depressurization signal that energizes one of the depressurization devices based on a plurality of operational conditions of the aircraft.

Abstract: The present invention provides novel compounds of Formula (I) and Formula (I(a)), or the pharmaceutically acceptable salts thereof; methods for treating neurological disorders and neurodegenerative diseases, particularly pain and migraine, comprising administering a compound of Formula (I) or Formula (I(a)); and processes for preparing compounds of Formula (I) or Formula (I(a)).

Abstract: The present invention provides novel compounds of Formula (I) and Formula (I(a)), or the pharmaceutically acceptable salts thereof; methods for treating neurological disorders and neurodegenerative diseases, particularly pain and migraine, comprising administering a compound of Formula (I) or Formula (I(a)); and processes for preparing compounds of Formula (I) or Formula (I(a)).

Abstract: The present invention relates to a one-pot process for preparing a compound of formula I: I; by reacting a compound of formula II with a compound of formula III: in the presence of a suitable solvent, a suitable base, a palladium catalyst and a suitable ligand.

Abstract: The present invention provides novel compounds of Formula (I) and Formula (I(a)), or the pharmaceutically acceptable salts thereof; methods for treating neurological disorders and neurodegenerative diseases, particularly pain and migraine, comprising administering a compound of Formula (I) or Formula (I(a)); and processes for preparing compounds of Formula (I) or Formula (I(a)).

Abstract: The present invention relates to a one-pot process for preparing a compound of formula I: I; by reacting a compound of formula II with a compound of formula III: in the presence of a suitable solvent, a suitable base, a palladium catalyst and a suitable ligand.

Abstract: This invention provides a process to prepare (2R)-anti-5-{3-[4-(10,11-difluoromethanodibenzosuber-5-yl)piperazin-1-yl]-2-hydroxypropoxy}quinoline.

Abstract: This invention provides a process to prepare (2R)-anti-5-{3-[4-(10,11-difluoromethanodibenzosuber-5-yl)piperazin-1-yl]-2-hydroxypropoxy}quinoline.

Abstract: This invention provides a process to prepare 10,11-(optionally substituted)methanodibenzosuberane derivatives. The invention also provides an intermediate in this process.

Abstract: The compounds are of the class of pyrrolo[2,3-d]pyrimidines useful for inhibiting sPLA2 mediated release of fatty acids for treatment of diseases such as septic shock.

Abstract: The invention provides a method of preparing compounds of formula I and VIII: ##STR1## which are useful intermediates to compounds that are used as antagonists and partial agonists for the serotonin receptor 5-HT.sub.4.

Abstract: The invention provides a method of preparing compounds of formula I and VIII: ##STR1## which are useful intermediates to compounds that are used as antagonists and partial agonists for the serotonin receptor 5-HT.sub.4.