Patents by Inventor Thomas Ming Hung Lee

Thomas Ming Hung Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ultra-stable oligonucleotide-gold and-silver nanoparticle conjugates and method of their preparation
    Patent number: 9605304
    Abstract: A method for stabilizing conjugates between macromolecule and nanoparticle by forming a thin reinforcement layer over the surface of a nanoparticle after macromolecule chains have attached to the surface of the nanoparticle. The stabilized conjugates can be used in a wide range of applications such as in vitro diagnostics, in vivo imaging and therapeutics, which need to be conducted under various severe or harsh conditions.
    Type: Grant
    Filed: April 3, 2012
    Date of Patent: March 28, 2017
    Assignee: The Hong Kong Polytechnic University
    Inventors: Thomas Ming Hung Lee, Kwun Fung Wong, Shea Ping Yip
  • Method and system for real time quantification and monitoring of nucleic acid amplification using electroconductive or electrochemically active labels
    Patent number: 8465926
    Abstract: A method and device for real time electrochemically or electrically monitoring and detecting nucleic acid amplification products, i.e. after each polymerase chain reaction cycle, utilizes electrochemically active or electrically conductive reporter materials. An electric voltage is applied and electric signals are measured during a PCR amplification process to the electrodes that is suitable for quantifying the amplified products of a sample's nucleic acid(s) produced. This technique is suitable for point-of-use applications, e.g. detecting bioanalytes in remote locations.
    Type: Grant
    Filed: August 10, 2007
    Date of Patent: June 18, 2013
    Assignee: The Hong Kong University of Science and Technology
    Inventors: I Ming Hsing, Thomas Ming Hung Lee, Stephen Siu Wai Yeung
  • Ultra-Stable Oligonucleotide-Gold And-Silver Nanoparticle Conjugates And Method Of Their Preparation
    Publication number: 20130022682
    Abstract: A method for stabilizing conjugates between macromolecule and nanoparticle by forming a thin reinforcement layer over the surface of a nanoparticle after macromolecule chains have attached to the surface of the nanoparticle. The stabilized conjugates can be used in a wide range of applications such as in vitro diagnostics, in vivo imaging and therapeutics, which need to be conducted under various severe or harsh conditions.
    Type: Application
    Filed: April 3, 2012
    Publication date: January 24, 2013
    Inventors: Thomas Ming Hung Lee, Kwun Fung Wong, Shea Ping Yip
  • METHOD AND SYSTEM FOR REAL TIME QUANTIFICATION AND MONITORING OF NUCLEIC ACID AMPLIFICATION USING ELECTROCONDUCTIVE OR ELECTROCHEMICALLY ACTIVE LABELS
    Publication number: 20100184028
    Abstract: A method and device for real time electrochemically or electrically monitoring and detecting nucleic acid amplification products, i.e. after each polymerase chain reaction cycle, utilizes electrochemically active or electrically conductive reporter materials. An electric voltage is applied and electric signals are measured during a PCR amplification process to the electrodes that is suitable for quantifying the amplified products of a sample's nucleic acid(s) produced. This technique is suitable for point-of-use applications, e.g. detecting bioanalytes in remote locations.
    Type: Application
    Filed: August 10, 2007
    Publication date: July 22, 2010
    Inventors: I Ming Hsing, Thomas Ming Hung Lee, Stephen Siu Wai Yeung