Abstract: A method is disclosed of treating pain with senicapoc, a potent Ca2+-activated K+ channel, KCa3.1 antagonist in CNS-resident microglia. Senicapoc is shown to cause in a decrease of IL-1? and NO release from microglia cells vivo and in vitro. Because of contribution of KCa3.1 to neuropathological processes, senicapoc is useful in the treatment of chronic, neuropathic, visceral, and inflammatory pain and the reversal of tactile allodynia.

Abstract: Neuroinflammation mediated by microglia and infiltrating peripheral immune cells is a major component of stroke pathophysiology. The calcium activated potassium channel KCa3.1 is expressed selectively in the injured CNS by microglia, and KCa3.1 function has been implicated in proinflammatory activation of microglia. KCa3.1 is further implicated in the pathophysiology of ischemia/reperfusion (stroke) related brain injury. Senicapoc, an investigational drug with a proven safety profile and shown to cross the blood-brain barrier, is a potent and selective KCa3.1 inhibitor that intervenes in the inflammation cascade that follows ischemia/reperfusion, and is a potential treatment for stroke.

Abstract: Neuroinflammation mediated by microglia and infiltrating peripheral immune cells is a major component of stroke pathophysiology. The calcium activated potassium channel KCa3.1 is expressed selectively in the injured CNS by microglia, and KCa3.1 function has been implicated in proinflammatory activation of microglia. KCa3.1 is further implicated in the pathophysiology of ischemia/reperfusion (stroke) related brain injury. Senicapoc, an investigational drug with a proven safety profile and shown to cross the blood-brain barrier, is a potent and selective KCa3.1 inhibitor that intervenes in the inflammation cascade that follows ischemia/reperfusion, and is a potential treatment for stroke.

Abstract: A radiation curable hot-melt adhesive is provided which contains a polyurethane polymer. This polyurethane polymer is prepared from A) a reactive polyurethane prepolymer which contains at least two NCO groups, B) a low molecular weight compound which comprises a free-radically polymerizable double bond and a functional group which reacts with a NCO group; C) a compound which comprises a functional group which reacts with a NCO group, but does not comprise a functional group polymerizable under free-radical condition; and D) a free-radical photoinitiator which contains a primary or secondary alcohol functional group. The radiation curable hot-melt adhesive is suitable as tapes, films, labels or articles for medical use with pressure-sensitively adhesive layers, in particular, for adhesively bonding shrinkable labels on rotationally symmetrical containers.

Abstract: The invention relates to a two-component bonding agent system, consisting of a component A and a component B, comprising A) at least one polymer that possesses at least one Michael acceptor group, and in addition at least one Michael donor group, B) a compound catalyzing the Michael reaction, as well as optional additional additives and/or auxiliaries, wherein the polymer of component A has a number average molecular weight (Mn) between 1000 g/mol and 1 000 000 g/mol. Furthermore, 2K-adhesives, casting compounds and coating agents made from such bonding agent systems are described.

Abstract: Sensor light having a light unit which can be activated in response to a sensor output signal from a motion sensor unit (16), and is provided on a support unit (10, 12) for installing the sensor light inside or outside, wherein that the motion sensor unit is modular, can be removed from the support unit when the latter is installed and has at least one actuating element (28) which can be manually operated and can be operated when the motion sensor unit has been removed.

Abstract: A power transistor, having: a semiconductor having an electrode formed thereon, wherein the electrode comprises a plurality of interdigitated transistors each having input and output terminals; a first output blocking capacitor having a first terminal electrically coupled to the output terminals of the interdigitated transistors of the semiconductor and a second terminal electrically coupled to ground; and a second output blocking capacitor having a first terminal electrically coupled to the first terminal of the first output blocking capacitor and a second terminal electrically coupled to ground.

Abstract: A power transistor, having: a semiconductor having an electrode formed thereon, wherein the electrode comprises a plurality of interdigitated transistors each having input and output terminals; a first output blocking capacitor having a first terminal electrically coupled to the output terminals of the interdigitated transistors of the semiconductor and a second terminal electrically coupled to ground; and a second output blocking capacitor having a first terminal electrically coupled to the first terminal of the first output blocking capacitor and a second terminal electrically coupled to ground.

Abstract: The present invention pertains to a water-soluble hotmelt adhesive, containing: 40 to 70% by weight of at least one homopolymer or copolymer with free carboxylic acid groups based on ethylenically unsaturated monomers (component A), 15 to 45% by weight of at least one water-soluble or water-dispersible polyurethane (component B), 10 to 45% by weight of at least one inorganic or organic base (component C), and 0 to 20% by weight of further additives (component D), wherein the sum of such components is 100% by weight. The water-soluble hotmelt adhesive is suitable for producing textile laminates, moisture-tackifiable papers and at least two-ply hygiene-papers, in particular tissue.

Abstract: The present invention pertains to a water-soluble hotmelt adhesive, containing: 40 to 70% by weight of at least one homopolymer or copolymer with free carboxylic acid groups based on ethylenically unsaturated monomers (component A), 15 to 45% by weight of at least one water-soluble or water-dispersible polyurethane (component B), 10 to 45% by weight of at least one inorganic or organic base (component C), and 0 to 20% by weight of further additives (component D), wherein the sum of such components is 100% by weight. The water-soluble hotmelt adhesive is suitable for producing textile laminates, moisture-tackifiable papers and at least two-ply hygiene-papers, in particular tissue.

Abstract: Linearity and/or efficiency of a power MOS transistor comprising a plurality of transistor segments connected in parallel, is improved in that at least one group of said transistor segments has a different threshold voltage than the rest of the transistor segments.

Abstract: A constant gain, constant phase RF power block, e.g., for use in a RF amplifier apparatus. In a preferred embodiment, the power block includes a DC to DC power supply circuit co-located with an RF power transistor device on a common heat sink. The power supply circuit has as an input a varying DC voltage and as outputs a constant supply voltage and a constant bias voltage. The power device has as inputs the constant supply voltage and the constant bias voltage, and further configured to receive and amplify an RF signal. The power supply circuit preferably includes a first laser trimmable resistor for setting the constant supply voltage and a second laser trimmable resistor for setting the bias voltage. In this manner, the constant supply and bias voltages may be easily tuned to a desired level during assembly of the power block device. The input and amplified RF signals are each matched to a relatively high impedance, e.g., approximately fifty ohms.

Abstract: A process for producing multilayered thin plasters comprising a carrier material based on polyurethane comprises

Abstract: An LDMOS power package includes a mounting substrate having a surface with one or more alignment pedestals extending therefrom. Each alignment pedestal has a mounting surface facing away from the substrate surface to provide for uniform positioning of various semiconductor elements, e.g., a transistor die or impedance matching capacitors, relative to the substrate surface. The respective pedestal mounting surfaces are preferably conductive, and are electrically coupled to the flange surface, so as to electrically couple the respective capacitor and electrode ground terminals to the flange.

Abstract: A packaged integrated circuit device includes a substrate including a first circuit component mounted thereon, a first conductor extending from the first circuit component, and a dielectric lid. The dielectric lid includes a component mounting surface, a second circuit component mounted on the component mounting surface, and a second conductor extending from the second circuit component. The dielectric lid is adapted to engage with the substrate such that the first circuit component is in electrical communication with the second circuit component. The second circuit component may comprises an impedance matching circuit. The circuit device may also include fastening means for securing the lid to the substrate. The fastening means may comprise an adhesive, solder, or a spring biased member.

Abstract: Linearity and/or efficiency of a power MOS transistor comprising a plurality of transistor segments connected in parallel, is improved in that at least one group of said transistor segments has a different threshold voltage than the rest of the transistor segments.

Abstract: A height-adjustable fastening system for a safety belt of a vehicle has a guide track and a slide slidably connected to the guide track and arrestable in various positions along the guide track. A fastening or guiding bracket is connected to the slide. A Bowden cable arrangement has a first end connected to the slide and a second end connected to a vehicle seat displaceable on a first and second seat tracks. The Bowden cable arrangement includes a sleeve and a cable pull displaceably guided within the sleeve. A stationary guide is positioned in the vicinity of the first seat track. The Bowden cable arrangement is guided about the stationary guide and the sleeve is connected to the stationary guide. The cable pull is connected with a first end to the vehicle seat at a fastening location remote from the stationary guide. The cable pull transmits a displacement movement of the vehicle seat onto the slide.

Abstract: A method of using compositions as foam regulators for water-based systems with a tendency to foam is provided. The method employs a block copolymer containing ester groups corresponding to general formula (I):A--(CH.sub.2 CH.sub.2 O).sub.n --B (I)in which n is an integer of 4 to 300, A is an optionally polymeric hydroxycarboxylic acid function and B is hydrogen, an alkyl or alkenyl radical containing 1 to 22 carbon atoms, a phenyl or benzyl radical or has the same meaning as A. Also provided is a granular free-flowing foam regulating formulation which contains 0.5% by weight to 30% by weight of the block copolymer containing ester groups adsorbed onto from 70% by weight to 99.5% by weight of a granular, substantially inorganic phosphate-free support material.

Abstract: A height-adjustable guide fitting for a seat belt of a motor vehicle has a rail member with a guide groove connected to the motor vehicle. The rail member has catch openings spaced at a distance from one another. A longitudinally slidable slide is positioned within the guide groove. A locking member is connected to the slide and in pivotable between a locked position and a release position. The locking member has a spring for biasing the locking member into the locked position and has a locking projection for engaging in the locked position a catch opening to thereby block the locking member relative to the rail member. A device for releasing the locking member is provided. The locking member has a lock lever pivotable between a position within the contour of the locking member and an outwardly pivoted engaging position for engaging one of the catch openings.

Abstract: A method and an apparatus for controlling an automated printing plate change process in a sheet-fed offset printing machine, in which a used printing plate is removed from the gripping portion of a clamping rail allocated to the leading edge of the plate cylinder and thereupon a new printing plate is guided into the opened gripping portion. Position sensors are used to determine, first, whether the front end of the used printing plate, and subsequently, whether the front end of the new printing plate, is in register in the leading edge clamping rail. Such information is used to control the plate change process. During the plate change process, the sensors are interrogated to determine whether the used plate has been removed from the plate cylinder, and whether the new printing plate is properly loaded.