Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: Computer-implemented methods and computer systems for an electronic transaction platform that enables the buying and/or selling of securities by users. The methods and systems relate to controlling communication of information during an electronic communication session for trading a financial instrument between an initiating user and one or more invitee users with the assistance of a dealer user or other intermediate entity. When a dealer with whom the initiating user has a relationship does not have a relationship with invitee users that may desire to trade for the security, a second dealer can be included in the electronic communication session, where the second dealer has a relationship with such invitee users. Various levels of participation are available for each user and correspond to what information each user is provided during the electronic communication session.

Abstract: The optical tracking module includes an optical phased array (OPA), an analog drive, an integrated photodetector, and one or more processors. The OPA includes a plurality of array elements, and a plurality of phase shifters. The analog drive is configured to adjust the plurality of phase shifters. The integrated photodetector is configured to receive light from the OPA. The one or more processors is configured to extract signal information of an incoming beam via the OPA, and control an outgoing beam using the analog drive based on the signal information. The OPA, the analog drive, the integrated photodetector and the one or more processors are in an integrated circuit.

Abstract: An end-stop control valve can progressively add end-of-stroke damping resistance to complement the damping force provided by a main piston in a damper tube. The end-stop control valve may include a piston that is secured on a piston rod and selectively engages a catch piston, both of which are longitudinally movable within the damper tube. As the piston approaches the catch piston, an annular pocket of hydraulic fluid is created longitudinally and radially between the piston and the catch piston. As the piston continues to approach the catch piston, a cross-sectional area through which hydraulic fluid exits the pocket decreases, thereby gradually increasing the resistance of the end-stop control valve. In addition, a spring disc secured on the piston rod may contact a valve seat on the catch piston and provide resistance by elastically deforming in a longitudinal direction before the contact surfaces of the piston and catch piston engage.

Abstract: Aerial vehicles are assigned to routes within a transportation network based on a state of charge, state of power, and/or state of health for the aerial vehicle. Such aspects can be modeled based on one or more statistical models and/or machine-learned models, among other examples. As another example, an energy budget is used to ensure that the state of charge, state of power, and/or state of health of the aerial vehicle during and/or after traveling the route remains within the energy budget. A payload is assigned to a route and an associated aerial vehicle, thereby generating an itinerary. In examples, the itinerary is validated by the aerial vehicle to ensure that the aerial vehicle is capable of traveling the route with the payload. In examples where the aerial vehicle rejects the itinerary, the itinerary is assigned to another aerial vehicle and a new itinerary is identified for the aerial vehicle.

Abstract: The present invention in an embodiment relates generally to mask/respirator having a filter assembly detachable therefrom.

Abstract: A method for amelioriation of, or prophylaxis against, a viral infection comprising administering to a patient in need of treatment a therapeutically effective amount of 5 aminolevulinic acid, optionally with at least one of cucumarin nano, zinc, vitamin C and methylene blue, and compositions thereof. Such compositions may be used for the treatment of coronavirus infections, including the SARS-CoV-2 virus, and/or rhinoviruses.

Abstract: The optical tracking module includes an optical phased array (OPA), an analog drive, an integrated photodetector, and one or more processors. The OPA includes a plurality of array elements, and a plurality of phase shifters. The analog drive is configured to adjust the plurality of phase shifters. The integrated photodetector is configured to receive light from the OPA. The one or more processors is configured to extract signal information of an incoming beam via the OPA, and control an outgoing beam using the analog drive based on the signal information. The OPA, the analog drive, the integrated photodetector and the one or more processors are in an integrated circuit.

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: A method, apparatus and/or system for measuring engine oil consumption using laser induced breakdown spectroscopy.

Abstract: A fumed silica monolithic integrating cavity device. The device is configured to facilitate optical measurements taken from a sample positioned within a cavity of the device. The cavity is defined by a fumed silica monolith with the added feature of a fused quartz lining on the surface of the monolith. This provides an intermediate surface that allows for cleaning and reuse of the highly effective diffuse light scattering fumed silica monolith. Furthermore, the lining may be placed under pressure or vacuum to structurally enhance mechanical integrity of the underlying monolith. Thus, continued or reliably repeated use of the device may be appreciated as well as use in more industrial environments that are prone to vibration.

Abstract: A lifting device with a head cavity in the lifting member shaped to accept a removable lifting head. The head cavity in the lifting device—e.g., the piston of a bottle jack—may be provided with threads, or may have the threads removed. A yoke fitted on the lifting head provides registration, horizontal restraint, or both against a lifted object, component, or surface to prevent sliding off the lifting head while in use. In a smooth-walled-shaft embodiment, a set of risers (spacers, adjusters, trims, or shims) serves to adjust an extension height of the shaft, elevating the lifting head with respect to the piston prior to beginning to lift the hydraulic piston.

Abstract: A seamless fumed silica monolithic integrating cavity device tailored to analyzing a flowed sample. The device is configured to facilitate optical measurements taken from a sample flowed through a cavity of the device. The cavity is defined by a fumed silica monolith with the added feature of a fused quartz lining on the surface of the monolith. This provides an intermediate surface that allows for cleaning and reuse of the highly effective diffuse light scattering fumed silica monolith. The lining may be placed under pressure or vacuum to structurally enhance mechanical integrity of the underlying monolith. Thus, continued or reliably repeated use of the device may be appreciated as well as use in more industrial environments that are prone to vibration. Additionally, while well suited for flow-based sample analysis, a valve of the cavity may be utilized for holding a sample in a temporarily static state for measurement.

Abstract: A security unit protects a glazing unit supported by a window frame The window frame defines a void that is in communication with an air space through external air vents. The window frame has a side panel that defines side panel holes. The security unit includes a security panel that is spaced apart from the glazing unit to define an air cavity and is secured to a vertical tubular bar that is secured to a side panel of the window frame. The vertical tubular bar defines a passage therethrough in communication with the air cavity through air cavity vents and defines passage holes aligned the side panel holes. Air circulates from the air cavity to the air space through the air cavity vents, the passage holes, the side panel holes and external air vents.

Abstract: A method, system and/or computer usable program product for managing optimization of a transportation network system including identifying a set of items for transportation between a set of origins and a set of destinations during a set of time periods, prioritizing each of the set of items, utilizing a set of network constraints and costs, utilizing a set of loading constraints for a set of transportation units, the loading constraints limiting the quantity and placement of items for each transportation unit, optimizing a quantity of the set of transportation units for transporting the set of items between the set of origins and the set of destinations during the set of time periods based on the prioritization of each of the set of items, the network constraints and costs, and the loading constraints for each transportation unit, and adjusting the optimized quantity of transportation units to a discrete quantity based on the prioritization of each of the set of items and the network constraints and costs.

Abstract: The optical tracking module includes an optical phased array (OPA), an analog drive, an integrated photodetector, and one or more processors. The OPA includes a plurality of array elements, and a plurality of phase shifters. The analog drive is configured to adjust the plurality of phase shifters. The integrated photodetector is configured to receive light from the OPA. The one or more processors is configured to extract signal information of an incoming beam via the OPA, and control an outgoing beam using the analog drive based on the signal information. The OPA, the analog drive, the integrated photodetector and the one or more processors are in an integrated circuit.

Abstract: A method, apparatus and/or system for measuring engine oil consumption using laser induced breakdown spectroscopy.