Abstract: The disclosure provides compositions and methods for cell therapy of hPAP in humans using gene corrected and in vitro differentiated patient autologous macrophage cells. The disclosure also provides compositions in the form of a cell product and related compositions and methods for making the cell product and for direct pulmonary transplantation of same.

Abstract: The present invention relates to the field of testing for pyrogens, e.g., endotoxin/LPS, non-endotoxin pyrogen (NEP), process-related impurities or endogenous pyrogens. This is highly relevant, e.g., for quality testing and safety testing of pharmaceutical compositions. The invention provides a method of testing a composition for the presence of at least one pyrogen, comprising (i) incubating a human monocyte or macrophage population derived from pluripotent stem cells in vitro, e.g., a human CD45+/CD11b+/CD14+/CD34?/TRA1-60? monocyte population or CD45+/CD11b+/CD14+/CD34?/TRA1-60?/CD163+ macrophage population derived from pluripotent stem cells with said composition, and (ii) determining a reaction of the monocytes in the population to the presence of the at least one pyrogen, preferably, determining the quantity of an inflammatory cytokine expressed by the monocytes.

Abstract: The present invention relates to genetically modified woody plants comprising a heterologous nucleic acid construct comprising a promoter sequence operably linked to a coding sequence encoding a gibberellin 20-oxidase gene product, wherein the promoter is preferentially or specifically expressed in meristematic tissue of said plant. The invention further relates to methods for producing such plants and to certain nucleic acid molecules useful as promoters.

Abstract: The present invention relates to stem-cell derived hematopoietic cells, in particular, myeloid cells, preferably, macrophages, their generation and use. In particular, the invention relates to a method of producing hematopoietic, preferably, myeloid cells, comprising cultivating embryoid bodies, which are, e.g., derivable from pluripotent stem cells such as induced pluripotent stem cells (iPSC), in suspension culture, to produce myeloid cell forming complexes, which are further cultivated in suspension culture to produce myeloid cells such as macrophages. This allows for a scalable and continuous production, e.g., in industry-compatible stirred tank bioreactors. Macrophages, e.g., macrophages produced with this method that have unique characteristics, can be used in pharmaceutical compositions for treatment of patients, e.g., for treatment of infection such as bacterial infection.

Abstract: The invention relates to an AC power adapter plate capable of being mounted to a wall, ceiling, or power receptacle which comprises ports for connecting and providing DC power to peripheral devices and accessories.

Abstract: The disclosure provides compositions and methods for cell therapy of hPAP in humans using gene corrected and in vitro differentiated patient autologous macrophage cells. The disclosure also provides compositions in the form of a cell product and related compositions and methods for making the cell product and for direct pulmonary transplantation of same.

Abstract: The invention relates to an AC power adapter plate capable of being mounted to a wall, ceiling, or power receptacle which comprises ports for connecting and providing DC power to peripheral devices and accessories.

Abstract: A method for constructing a shelf assembly in a locker comprising the steps of: inserting a first sidewall having a transverse slot between upper and lower ends of the sidewall and an inner shoulder at the upper end of the sidewall in the locker against a sidewall of the locker; inserting a second sidewall having a transverse slot located between the upper and lower ends of the sidewall in the locker higher than the first sidewall and holding the second sidewall at that higher position while a first shelf is inserted at an angle with side edges of the shelf generally aligned with the slots; lowering the second sidewall and the first shelf with the side edges engaged in the slots; and, once the lower ends of the sidewalls are firmly supported on a bottom of the locker, inserting the second shelf on the shoulders of the sidewalls.

Abstract: A method for detecting analytes in flow rate analysis and chromatography is described. The method comprises the following steps: a) providing one or more light sources, an optical wave guide, a container containing a specimen with one or more analytes, and one or more detectors; b) exposing the container containing the specimen to light of one or various, defined wavelengths and/or wavelength ranges; and c) detecting the resulting light waves by one or more detectors after the specimen container is exposed to light of one or various defined wavelengths and/or wavelength ranges, wherein the specimen is irradiated by transferring the light waves through an non-flexible or non-flexibly arranged optical wave guide before the light waves enter the specimen container. The non-flexible or non-flexibly arranged optical wave guide is not susceptible to interference and permits selective irradiation with one or more wavelengths sequentially or simultaneously without requiring much time.

Abstract: A method for electrodepositing a metal layer from an electrolytic bath is described, wherein the concentrations of at least two components of the electrolytic bath are monitored by carrying out the following steps: (a) a sample is taken from the electrolytic bath; (b) the sample is supplied to a column for solid phase extraction, which contains a solid sorbent material; (c) the column is subjected to a washing procedure with a first eluent, wherein the at least two components remain on the column, and undesired components are eluted from the column; (d) the at least two components are eluted from the column by a second eluent; (e) the concentrations of the at least two components in the eluate obtained in step (d) are determined without separating the components from each other. In this method the use of poly(divinyl benzene-co-N-vinyl pyrrolidone) for solid phase extraction is particularly advantageous.

Abstract: A method for constructing a shelf assembly in a locker comprising the steps of: inserting a first sidewall having a transverse slot between upper and lower ends of the sidewall and an inner shoulder at the upper end of the sidewall in the locker against a sidewall of the locker; inserting a second sidewall having a transverse slot located between the upper and lower ends of the sidewall in the locker higher than the first sidewall and holding the second sidewall at that higher position while a first shelf is inserted at an angle with side edges of the shelf generally aligned with the slots; lowering the second sidewall and the first shelf with the side edges engaged in the slots; and, once the lower ends of the sidewalls are firmly supported on a bottom of the locker, inserting the second shelf on the shoulders of the sidewalls.

Abstract: The method for constructing a shelf assembly in a locker having on each side thereof a generally vertically extending longitudinal lip, the lip on one side of the locker hingedly mounting a locker door, comprises the steps of: providing a first sidewall having in an inner sidewall surface thereof a transverse slot located generally midway between upper and lower ends of the sidewall and an inner shoulder at the upper end of the sidewall and a second sidewall having in an inner sidewall surface thereof a transverse slot located generally midway between the upper and lower ends of the sidewall and an inner shoulder at the upper end of the sidewall a first shelf and a second shelf: Inserting the first sidewalls in the locker against a sidewall of the locker; Inserting the second sidewall in the locker higher than the first sidewall and holding the second sidewall at that higher position while the first shelf is inserted at an angle but with side edges of the shelf generally aligned with the slots; lowering the s

Abstract: For the reproducible manufacturing of particularly uniform and brilliant i.e., highly bright copper coatings that are leveled and ductile as well, a copper plating bath is utilized that contains as an additive a mixture of oligomeric phenazinium compounds. The mixture contains at least one phenazinium compound selected from the group comprising compounds containing two monomeric units and compounds containing three monomeric units having the general chemical formulae <I> and <II> set forth in the patent claims and in the specification as well as further oligomeric phenazinium compounds.

Abstract: The method for constructing a shelf assembly in a locker having on each side thereof a generally vertically extending longitudinal lip, the lip on one side of the locker hingedly mounting a locker door, comprises the steps of: providing a first sidewall having in an inner sidewall surface thereof a transverse slot located generally midway between upper and lower ends of the sidewall and an inner shoulder at the upper end of the sidewall and a second sidewall having in an inner sidewall surface thereof a transverse slot located generally midway between the upper and lower ends of the sidewall and an inner shoulder at the upper end of the sidewall a first shelf and a second shelf: Inserting the first sidewalls in the locker against a sidewall of the locker; Inserting the second sidewall in the locker higher than the first sidewall and holding the second sidewall at that higher position while the first shelf is inserted at an angle but with side edges of the shelf generally aligned with the slots; lowering the s

Abstract: Important aims in nearly all tree-breeding programs around the world are to produce plants with increased growth rates and stem volumes, and shorter rotation times. Such trees would yield more biomass per area unit. Here the present inventors have shown that when over-expressing a key regulatory gene in the biosynthesis of the plant hormone gibberellin (GA) in hybrid aspen (Populus tremula×P. tremuloides), improvements in valuable traits such as growth rate and biomass are obtained. In addition, these trees also have longer xylem fibres than unmodified wild type plants. Long fibers are very desirable in the production of strong paper, but it has not (as yet) proved possible to influence this trait by traditional breeding techniques. A further advantage of the present invention is that it may reduce or eliminate the use of growth influencing chemicals in forestry.

Abstract: A method for electrodepositing a metal layer from an electrolytic bath is described, wherein the concentrations of at least two components of the electrolytic bath are monitored by carrying out the following steps: (a) a sample is taken from the electrolytic bath; (b) the sample is supplied to a column for solid phase extraction, which contains a solid sorbent material; (c) the column is subjected to a washing procedure with a first eluent, wherein the at least two components remain on the column, and undesired components are eluted from the column; (d) the at least two components are eluted from the column by a second eluent; (e) the concentrations of the at least two components in the eluate obtained in step (d) are determined without separating the components from each other. In this method the use of poly(divinyl benzene-co-N-vinyl pyrrolidone) for solid phase extraction is particularly advantageous.

Abstract: The plating bath for the deposition of satin nickel deposits according to the present invention contains at least one quarternary ammonium compound and at least one polyether, the at least one polyether having at least one strongly hydrophobic side chain. As compared to prior art plating baths, this acid plating bath has the advantage that it enables a long period of operation or heating and cooling cycles or filtration cycles, makes it possible to perform the filtration needed for continually operating the bath without using active carbon, requires a lower concentration of nickel than prior art baths to produce the satin gloss finish and has a reduced sensitivity to wetting agents that have been dragged in.

Abstract: Important aims in nearly all tree-breeding programs around the world are to produce plants with increased growth rates and stem volumes, and shorter rotation times. Such trees would yield more biomass per area unit. Here the present inventors have shown that when over-expressing a key regulatory gene in the biosynthesis of the plant hormone gibberellin (GA) in hybrid aspen (Populus tremula×P. tremuloides), improvements in valuable traits such as growth rate and biomass are obtained. In addition, these trees also have longer xylem fibres than unmodified wild type plants. Long fibres are very desirable in the production of strong paper, but it has not (as yet) proved possible to influence this trait by traditional breeding techniques. A further advantage of the present invention is that it may reduce or eliminate the use of growth influencing chemicals in forestry.

Abstract: Important aims in nearly all tree-breeding programs around the world are to produce plants with increased growth rates and stem volumes, and shorter rotation times. Such trees would yield more biomass per area unit. Here the present inventors have shown that when over-expressing a key regulatory gene in the biosynthesis of the plant hormone gibberellin (GA) in hybrid aspen (Populus tremula×P. tremuloides), improvements in valuable traits such as growth rate and biomass are obtained. In addition, these trees also have longer xylem fibers than unmodified wild type plants. Long fibres are very desirable in the production of strong paper, but it has not (as yet) proved possible to influence this trait by traditional breeding techniques. A further advantage of the present invention is that it may reduce or eliminate the use of growth influencing chemicals in forestry.

Abstract: The present invention relates to a porous film comprising metal oxide particles, to a sample holder using the film, to a method of preparation for the sample holder, to the application of the sample holder as well as to a method of detecting phosphorylated/sulphated biopolymers, specifically peptides/proteins.