Abstract: A turbine comprising a wastegate chamber (28): a turbine housing (12) defining a turbine inlet (14), the turbine housing (12) comprising: a wastegate inlet passageway (30) defining a flow path between the turbine inlet (14) and the wastegate chamber (28), wherein the wastegate inlet passageway (30) comprises a turbine port (38) proximal the turbine inlet (14) and a non-circular valve port (36) proximal the wastegate chamber (28), and a raised rim (52) surrounding the non-circular valve port (36) and conformal to the shape of the non-circular valve port (36), wherein the raised rim comprises a first sealing surface (52); and a valve member (42) comprising a second sealing surface (50), wherein the valve member (42) is moveable between a closed position in which the second sealing surface (50) forms a seal with the first sealing surface (54) to prevent fluid flow along the flow path and an open position in which the second scaling surface (50) is spaced apart from the first sealing surface (54) to permit fluid

Abstract: The disclosure provides for a targeting transfer RNA (ttRNA) that that suppresses nonsense mutations in messenger RNA, that comprises an anticodon sequence that binds to a stop codon and a variable loop sequence that comprises an RNA aptamer that has strong binding affinity to an RNA binding protein; and methods of use thereof.

Abstract: A valve system comprising a valve chamber at a junction of an inlet port, an outlet port and a bypass port, the inlet port configured for fluid communication with exhaust gas, the outlet port configured for fluid communication with an inlet of a turbine, and the bypass port configured for fluid communication with an exhaust aftertreatment device; a rotary valve comprising a valve rotor which rotates about a valve axis within the valve chamber between a first position to permit gas flow through the bypass port and a second position to block gas flow. At least one of the valve rotor and the valve chamber comprises a protrusion and the other comprises a recess, wherein, in the first position, the protrusion and recess are spaced from one another, and, in the second position the recess receives the protrusion such that gas flow between the protrusion and recess is substantially prevented.

Abstract: A rotary turbine bypass valve comprises a valve chamber positioned at a junction of an inlet port, an outlet port and a bypass port, the inlet port configured for fluid communication with a flow of exhaust gas from an engine, the outlet port configured for fluid communication with an inlet of a turbine, and the bypass port configured for fluid communication with an exhaust aftertreatment device; and a valve rotor supported for rotation, about a valve axis, within the valve chamber. The valve rotor is rotatable about the valve axis between a first position in which the valve rotor permits gas flow through the bypass port and a second position in which the valve rotor blocks gas flow through the bypass port.

Abstract: A valve system comprising a valve chamber at a junction of an inlet port, an outlet port and a bypass port, the inlet port configured for fluid communication with exhaust gas, the outlet port configured for fluid communication with an inlet of a turbine, and the bypass port configured for fluid communication with an exhaust aftertreatment device; a rotary valve comprising a valve rotor which rotates about a valve axis within the valve chamber between a first position to permit gas flow through the bypass port and a second position to block gas flow. At least one of the valve rotor and the valve chamber comprises a protrusion and the other comprises a recess, wherein, in the first position, the protrusion and recess are spaced from one another, and, in the second position the recess receives the protrusion such that gas flow between the protrusion and recess is substantially prevented.

Abstract: The turbine arrangement includes a turbine including a turbine housing which defines a turbine cavity within which a turbine wheel is supported, an inlet upstream of the wheel and an outlet downstream. The arrangement also includes a flow passage configured to permit gas flow without interacting with the wheel, and a valve member moveable between an open configuration wherein gas may flow through the flow passage, and a closed configuration wherein gas is substantially prevented from flowing, a first actuator portion for moving the valve member between the configurations, and a second actuator portion in gas flow communication with a portion of the arrangement upstream of the wheel via an actuator gas passage. The arrangement is configured such that gas may flow through the actuator gas passage to the second actuator portion, where it acts on the second actuator portion to urge the valve member towards the closed configuration.

Abstract: A rotary turbine bypass valve comprises a valve chamber positioned at a junction of an inlet port, an outlet port and a bypass port, the inlet port configured for fluid communication with a flow of exhaust gas from an engine, the outlet port configured for fluid communication with an inlet of a turbine, and the bypass port configured for fluid communication with an exhaust aftertreatment device; and a valve rotor supported for rotation, about a valve axis, within the valve chamber. The valve rotor is rotatable about the valve axis between a first position in which the valve rotor permits gas flow through the bypass port and a second position in which the valve rotor blocks gas flow through the bypass port.

Abstract: The turbine arrangement includes a turbine including a turbine housing which defines a turbine cavity within which a turbine wheel is supported, an inlet upstream of the wheel and an outlet downstream. The arrangement also includes a flow passage configured to permit gas flow without interacting with the wheel, and a valve member moveable between an open configuration wherein gas may flow through the flow passage, and a closed configuration wherein gas is substantially prevented from flowing, a first actuator portion for moving the valve member between the configurations, and a second actuator portion in gas flow communication with a portion of the arrangement upstream of the wheel via an actuator gas passage. The arrangement is configured such that gas may flow through the actuator gas passage to the second actuator portion, where it acts on the second actuator portion to urge the valve member towards the closed configuration.

Abstract: A valve system comprising a valve chamber at a junction of an inlet port, an outlet port and a bypass port, the inlet port configured for fluid communication with exhaust gas, the outlet port configured for fluid communication with an inlet of a turbine, and the bypass port configured for fluid communication with an exhaust aftertreatment device; a rotary valve comprising a valve rotor which rotates about a valve axis within the valve chamber between a first position to permit gas flow through the bypass port and a second position to block gas flow. At least one of the valve rotor and the valve chamber comprises a protrusion and the other comprises a recess, wherein, in the first position, the protrusion and recess are spaced from one another, and, in the second position the recess receives the protrusion such that gas flow between the protrusion and recess is substantially prevented.