Patents by Inventor Thomas Mulhern

Thomas Mulhern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regeneratable Biosensor and Methods of Use Thereof
    Publication number: 20190310260
    Abstract: A multiplex-able, regeneratable nucleic-acid linked immunoassay method and system for the detection of a single specific, or multiple, soluble analytes in solution and regeneratable biosensor devices for same are described.
    Type: Application
    Filed: June 4, 2019
    Publication date: October 10, 2019
    Inventors: Stephanie Angione, Madeline Cooper, Jonathan Coppeta, Thomas Mulhern, Hesham Azizgolshani
  • Regeneratable Biosensor and Methods of Use Thereof
    Publication number: 20180149656
    Abstract: A multiplex-able, regeneratable nucleic-acid linked immunoassay method and system for the detection of a single specific, or multiple, soluble analytes in solution and regeneratable biosensor devices for same are described.
    Type: Application
    Filed: November 29, 2017
    Publication date: May 31, 2018
    Inventors: Stephanie Angione, Madeline Cooper, Jonathan Coppeta, Thomas Mulhern, Hesham Azizgolshani
  • Asymmetric synthesis of pregabalin
    Patent number: 6891059
    Abstract: This invention provides a method of making (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) or a salt thereof via an asymmetric hydrogenation synthesis. Pregabalin is useful for the treatment and prevention of seizure disorders, pain, and psychotic disorders. The invention also provides intermediates useful in the production of pregabalin.
    Type: Grant
    Filed: January 11, 2001
    Date of Patent: May 10, 2005
    Assignee: Warner-Lambert Company
    Inventors: Mark Joseph Burk, Om Prakash Goel, Marvin Simon Hoekstra, Thomas Frederick Mich, Thomas Mulhern, James A. Ramsden
  • Asymmetric synthesis of pregabalin
    Publication number: 20030212290
    Abstract: This invention provides a method of making (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) or a salt thereof via an asymmetric hydrogenation synthesis. Pregabalin is useful for the treatment and prevention of seizure disorders, pain, and psychotic disorders. The invention also provides intermediates useful in the production of pregabalin.
    Type: Application
    Filed: March 7, 2003
    Publication date: November 13, 2003
    Inventors: Mark Joseph Burk, Omprakash Goel, Marvin Simon Hoekstra, Thomas Frederick Mich, Thomas Mulhern, James A. Ramsden
  • Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
    Patent number: 6046353
    Abstract: A method of making (.+-.)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with ##STR1## to form primarily ##STR2## reacting the ##STR3## with a cyanide source to form ##STR4## decarboxylating the ##STR5## to form ##STR6## hydrolyzing the ##STR7## with an alkali or alkaline earth metal hydroxide to form an alkali or alkaline earth metal carboxylate salt; and hydrogenating the alkali or alkaline earth metal carboxylate salt to form (.+-.)-3-(aminomethyl)-5-methylhexanoic acid, wherein R.sub.1 and R.sub.2 are the same or different and are hydrogen, C.sub.1 -C.sub.6 alkyl, aryl, benzyl, or C.sub.3 -C.sub.6 cycloalkyl. The present invention also provides a method of making (.+-.
    Type: Grant
    Filed: August 26, 1998
    Date of Patent: April 4, 2000
    Assignee: Warner-Lambert Company
    Inventors: Todd Michel Grote, Brian Keith Huckabee, Thomas Mulhern, Denis Martin Sobieray, Robert Daniel Titus
  • Method of making (S)-3-(Aminomethyl)-5-Methylhexanoic acid
    Patent number: 5840956
    Abstract: A method of making (.+-.)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with ##STR1## to form primarily ##STR2## reacting the ##STR3## with a cyanide source to form ##STR4## decarboxylating the ##STR5## to form ##STR6## hydrolyzing the ##STR7## with an alkali or alkaline earth metal hydroxide to form an alkali or alkaline earth metal carboxylate salt; and hydrogenating the alkali or alkaline earth metal carboxylate salt to form (.+-.)-3-(aminomethyl)-5-methylhexanoic acid, wherein R.sub.1 and R.sub.2 are the same or different and are hydrogen, C.sub.1 -C.sub.6 alkyl, aryl, benzyl, or C.sub.3 -C.sub.6 cycloalkyl. The present invention also provides a method of making (.+-.
    Type: Grant
    Filed: February 6, 1997
    Date of Patent: November 24, 1998
    Assignee: Warner-Lambert Company
    Inventors: Todd Michel Grote, Brian Keith Huckabee, Thomas Mulhern, Denis Martin Sobieray, Robert Daniel Titus
  • Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
    Patent number: 5637767
    Abstract: A method of making (.+-.)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with ##STR1## to form primarily ##STR2## reacting the ##STR3## with a cyanide source to form ##STR4## decarboxylating the ##STR5## to form ##STR6## hydrolyzing the ##STR7## with an alkali or alkaline earth metal hydroxide to form an alkali or alkaline earth metal carboxylate salt; and hydrogenating the alkali or alkaline earth metal carboxylate salt to form (.+-.)-3-(aminomethyl)-5-methylhexanoic acid, wherein R.sub.1 and R.sub.2 are the same or different and are hydrogen, C.sub.1 -C.sub.6 alkyl, aryl, benzyl, or C.sub.3 -C.sub.6 cycloalkyl. The present invention also provides a method of making (.+-.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 10, 1997
    Assignee: Warner-Lambert Company
    Inventors: Todd M. Grote, Brian K. Huckabee, Thomas Mulhern, Denis M. Sobieray, Robert D. Titus