Patents by Inventor Thomas N. Chiesl

Thomas N. Chiesl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and methods for isolating nucleic acids from cellular samples
    Patent number: 10227582
    Abstract: The present disclosure relates to systems and methods for nucleic acid isolation from cellular samples. In particular, the present disclosure provides systems and methods for lysing cells and recovering nucleic acids.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: March 12, 2019
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: Thomas N. Chiesl, Michelle Toro, Steven Gerald Haupt
  • MODIFIED NUCLEIC ACIDS FOR NANOPORE ANALYSIS
    Publication number: 20180164280
    Abstract: Provided herein is technology relating to nanopore analysis of nucleic acids and particularly, but not exclusively, to compositions, methods, systems, and kits for analysis of nucleic acids or other assays comprising nucleic acid components.
    Type: Application
    Filed: November 6, 2017
    Publication date: June 14, 2018
    Inventors: David J. Ecker, Stanley T. Motley, James C. Hannis, Lara G. Krieg, Todd P. Michael, David D. Duncan, Shane G. Poplawski, Thomas N. Chiesl
  • COMPOSITIONS AND METHODS FOR SAMPLE PREPARATION
    Publication number: 20160376636
    Abstract: The invention relates generally to compositions and methods for disrupting cells (e.g., disrupting cellular and nuclear membranes). In particular, the invention provides modified solid surfaces (e.g., bead surfaces) and their use in disruption of cellular membranes (e.g., during cellular lysis procedures (e.g., for recovery of nucleic acid (e.g., DNA or RNA) from mechanical cell lysis)). Compositions and methods of the invention find use in a wide range of applications including molecular biology and medical science.
    Type: Application
    Filed: September 12, 2016
    Publication date: December 29, 2016
    Inventor: Thomas N. Chiesl
  • SYSTEMS AND METHODS FOR ISOLATING NUCLEIC ACIDS FROM CELLULAR SAMPLES
    Publication number: 20160326513
    Abstract: The present disclosure relates to systems and methods for nucleic acid isolation from cellular samples. In particular, the present disclosure provides systems and methods for lysing cells and recovering nucleic acids.
    Type: Application
    Filed: May 9, 2016
    Publication date: November 10, 2016
    Inventors: Thomas N. Chiesl, Michelle Toro, Steven Gerald Haupt
  • Compositions and methods for sample preparation
    Patent number: 9441265
    Abstract: The invention relates generally to compositions and methods for disrupting cells (e.g., disrupting cellular and nuclear membranes). In particular, the invention provides modified solid surfaces (e.g., bead surfaces) and their use in disruption of cellular membranes (e.g., during cellular lysis procedures (e.g., for recovery of nucleic acid (e.g., DNA or RNA) from mechanical cell lysis)). Compositions and methods of the invention find use in a wide range of applications including molecular biology and medical science.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: September 13, 2016
    Assignee: IBIS BIOSCIENCES, INC.
    Inventor: Thomas N. Chiesl
  • NUCLEIC ACID AMPLIFICATION APPARATUS AND SYSTEM
    Publication number: 20160184829
    Abstract: This present disclosure relates to devices, systems, and methods for performing biological assays. In particular, the present disclosure provides microfluidic devices, systems, and methods for performing fast amplification reactions.
    Type: Application
    Filed: October 22, 2015
    Publication date: June 30, 2016
    Inventors: Thomas N. Chiesl, Steven G. Haupt
  • Systems and methods for isolating nucleic acids from cellular samples
    Patent number: 9334491
    Abstract: The present disclosure relates to systems and methods for nucleic acid isolation from cellular samples. In particular, the present disclosure provides systems and methods for lysing cells and recovering nucleic acids.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: May 10, 2016
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: Thomas N. Chiesl, Michelle Toro, Steven Gerald Haupt
  • SYSTEMS AND METHODS FOR NUCLEIC ACID CAPTURE
    Publication number: 20160122810
    Abstract: Provided herein are methods for improving the detection sensitivity of amplification reaction products. In particular, provided herein are methods of improving sensitivity of detection of amplification products by introducing modified and degradable nucleotides into amplification primers.
    Type: Application
    Filed: October 22, 2015
    Publication date: May 5, 2016
    Inventors: Thomas N. Chiesl, Steven G. Haupt, Lendell L. Cummins, Christopher D. Crowder
  • SWAB PORT FOR MICROFLUIDIC DEVICES
    Publication number: 20160116381
    Abstract: Provided herein are apparatuses for introducing a liquid over a sample of interest (e.g., a sample on a swab), and related systems and methods utilizing such apparatuses (e.g., microfluidic analyses).
    Type: Application
    Filed: October 23, 2015
    Publication date: April 28, 2016
    Inventors: Steven G. Haupt, Steven A. Hofstadler, Thomas N. Chiesl, Bradley J. Sargent
  • APPARATUSES FOR STERILELY DELIVERING FLUID
    Publication number: 20160116379
    Abstract: Provided herein are apparatuses, systems, kits and methods for sterilely delivering fluid to an elongated swab. In particular, provided herein are apparatuses configured to sterilely deliver a desired fluid to a swab contained within a swab housing.
    Type: Application
    Filed: October 22, 2015
    Publication date: April 28, 2016
    Inventors: James C. Hannis, Sherilynn Manalili Wheeler, Thomas N. Chiesl, Jared J. Drader, Steven A. Hofstadler, Ronald K. Bergold, Paul J. Gleason, Zachary T. Hannis
  • Microfluidic transducer
    Patent number: 9217132
    Abstract: Provided herein are apparatuses and methods for fragmenting nucleic acids or disrupting cells. For example, some embodiments provide a disposable microfluidic device designed to position a sample to be in direct contact with a high frequency vibrating element that emits an ultrasonic frequency into the sample such that the vibrational energy transduced into the sample results in fragmenting nucleic acids or disrupting cells.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: December 22, 2015
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: Mark W. Eshoo, Jose R. Gutierrez, Jared J. Drader, John Picuri, Karl M. Cabrera, Stanley Motley, Thomas N. Chiesl
  • SWAB INTERFACE FOR A MICROFLUIDIC DEVICE
    Publication number: 20150241319
    Abstract: The present disclosure relates to a swab port device. In particular, the present disclosure relates to swab port device that interfaces a swab to a microfluidic device, methods of bonding the swab port to the device, methods of recirculating liquid over the swab, and an enclosure system to seal the device.
    Type: Application
    Filed: September 26, 2013
    Publication date: August 27, 2015
    Inventors: Thomas N. Chiesl, Steven G. Haupt, Ronald K. Bergold, Bradley J. Sargent, Steven A. Hofstadler
  • SYSTEMS AND METHODS FOR ISOLATING NUCLEIC ACIDS FROM CELLULAR SAMPLES
    Publication number: 20150184148
    Abstract: The present disclosure relates to systems and methods for nucleic acid isolation from cellular samples. In particular, the present disclosure provides systems and methods for lysing cells and recovering nucleic acids.
    Type: Application
    Filed: December 21, 2012
    Publication date: July 2, 2015
    Inventors: Thomas N. Chiesl, Michelle Toro, Steven Gerald Haupt
  • COMPOSITIONS AND METHODS FOR SAMPLE PREPARATION
    Publication number: 20140363822
    Abstract: The invention relates generally to compositions and methods for disrupting cells (e.g., disrupting cellular and nuclear membranes). In particular, the invention provides modified solid surfaces (e.g., bead surfaces) and their use in disruption of cellular membranes (e.g., during cellular lysis procedures (e.g., for recovery of nucleic acid (e.g., DNA or RNA) from mechanical cell lysis)). Compositions and methods of the invention find use in a wide range of applications including molecular biology and medical science.
    Type: Application
    Filed: December 28, 2012
    Publication date: December 11, 2014
    Inventor: Thomas N. Chiesl
  • Physically crosslinked copolymer compounds and related compositions and methods for electrophoretic separation
    Patent number: 8207258
    Abstract: Linear acrylamide copolymer compounds which can comprise monomeric components comprising at least one N-substituted moiety capable of physical cross-linking, and related compositions and methods of use.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: June 26, 2012
    Assignee: Northwestern University
    Inventors: Thomas N. Chiesl, Annelise E. Barron
  • Physically Crosslinked Copolymer Compounds and Related Compositions and Methods for Electrophoretic Separation
    Publication number: 20120000780
    Abstract: Linear acrylamide copolymer compounds which can comprise monomeric components comprising at least one N-substituted moiety capable of physical cross-linking, and related compositions and methods of use.
    Type: Application
    Filed: September 12, 2011
    Publication date: January 5, 2012
    Applicant: Northwestern University
    Inventors: Thomas N. Chiesl, Annelise E. Barron
  • Physically crosslinked copolymer compounds and related compositions and methods for electrophoretic separation
    Patent number: 8017682
    Abstract: Linear acrylamide copolymer compounds which can comprise monomeric components comprising at least one N-substituted moiety capable of physical cross-linking, and related compositions and methods of use.
    Type: Grant
    Filed: May 14, 2007
    Date of Patent: September 13, 2011
    Assignee: Northwestern University
    Inventors: Thomas N. Chiesl, Annelise E. Barron