Patents by Inventor Thomas N. Tulenko

Thomas N. Tulenko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170000923
    Abstract: The disclosure relates to a composition that is liquid at a temperature below the body temperature of a mammal and that solidifies at or above the body temperature of the mammal. The composition includes a thermally-desolubilizable polymer interspersed with a polymeric component of extracellular matrix and an encapsulated form of an amine compound (preferably an aminated component of extracellular matrix) that is de-encapsulated in the body of the mammal. The polymeric component is able to form covalent bonds with amine moieties in the aminated component, in one or more tissues in the body of the mammal, or both. Upon injection off liquid suspension of these components into the body of the mammal, the thermally-desolubilizable polymer condenses, entrapping the polymeric component. The polymeric component binds covalently with a tissue in the body, and the aminated component end-caps the remaining reactive moieties of the polymeric component, forming a matrix at the site of injection.
    Type: Application
    Filed: September 19, 2016
    Publication date: January 5, 2017
    Applicant: Rowan University
    Inventors: Andrea J. Vernengo, Jennifer Kadlowec, Pamela Kubinski, Thomas N. Tulenko, Cristina Iftode, Bryan Johnson, Craig Wiltsey
  • Patent number: 9446167
    Abstract: The disclosure relates to a composition that is liquid at a temperature below the body temperature of a mammal and that solidifies at or above the body temperature of the mammal. The composition includes a thermally-desolubilizable polymer interspersed with a polymeric component of extracellular matrix and an encapsulated form of an amine compound (preferably an aminated component of extracellular matrix) that is de-encapsulated in the body of the mammal. The polymeric component is able to form covalent bonds with amine moieties in the aminated component, in one or more tissues in the body of the mammal, or both. Upon injection of a liquid suspension of these components into the body of the mammal, the thermally-desolubilizable polymer condenses, entrapping the polymeric component. The polymeric component binds covalently with a tissue in the body, and the aminated component end-caps the remaining reactive moieties of the polymeric component, forming a matrix at the site of injection.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: September 20, 2016
    Inventors: Andrea Jennifer Vernengo, Jennifer Kadlowec, Pamela Kubinski, Thomas N. Tulenko, Cristina Iftode, Bryan Johnson, Craig Wiltsey
  • Publication number: 20160158406
    Abstract: The disclosure relates to a composition that is liquid at a temperature below the body temperature of a mammal and that solidifies at or above the body temperature of the mammal. The composition includes a thermally-desolubilizable polymer interspersed with a polymeric component of extracellular matrix and an encapsulated form of an amine compound (preferably an aminated component of extracellular matrix) that is de-encapsulated in the body of the mammal. The polymeric component is able to form covalent bonds with amine moieties in the aminated component, in one or more tissues in the body of the mammal, or both. Upon injection of a liquid suspension of these components into the body of the mammal, the thermally-desolubilizable polymer condenses, entrapping the polymeric component. The polymeric component binds covalently with a tissue in the body, and the aminated component end-caps the remaining reactive moieties of the polymeric component, forming a matrix at the site of injection.
    Type: Application
    Filed: February 11, 2016
    Publication date: June 9, 2016
    Applicant: Rowan University
    Inventors: Andrea Jennifer Vernengo, Jennifer Kadlowec, Pamela Kubinski, Thomas N. Tulenko, Cristina Iftode, Bryan Johnson, Craig Wiltsey
  • Patent number: 9295761
    Abstract: The disclosure relates to a composition that is liquid at a temperature below the body temperature of a mammal and that solidifies at or above the body temperature of the mammal. The composition includes a thermally-desolubilizable polymer interspersed with a polymeric component of extracellular matrix and an encapsulated form of an amine compound (preferably an aminated component of extracellular matrix) that is de-encapsulated in the body of the mammal. The polymeric component is able to form covalent bonds with amine moieties in the aminated component, in one or more tissues in the body of the mammal, or both. Upon injection of a liquid suspension of these components into the body of the mammal, the thermally-desolubilizable polymer condenses, entrapping the polymeric component. The polymeric component binds covalently with a tissue in the body, and the aminated component end-caps the remaining reactive moieties of the polymeric component, forming a matrix at the site of injection.
    Type: Grant
    Filed: October 15, 2012
    Date of Patent: March 29, 2016
    Inventors: Andrea Jennifer Vernengo, Jennifer Kadlowec, Pamela Kubinski, Thomas N Tulenko, Cristina Iftode, Bryan Johnson, Craig Wiltsey
  • Patent number: 4229733
    Abstract: An exposure detecting device comprising a radiation detector means providing an output signal responsive to the intensity of received ultraviolet radiation, a storage means receiving the output signal of said detector means and providing an output signal which increases as a function of the signal received and its duration, and decreases in the absence of a received signal as a predetermined function of time. A sensitivity control means provides a reference signal, and comparing means receives the output signal of said storage means and the reference signal of said sensitivity control means and delivers an output signal when the storage means output signal exceeds a predetermined value with respect to the reference signal. Alarm means is activated upon receiving an output signal from said comparing means providing an alarm.
    Type: Grant
    Filed: August 10, 1978
    Date of Patent: October 21, 1980
    Assignee: Thomas N. Tulenko
    Inventors: Thomas N. Tulenko, Carmen A. Di Camillo