Patents by Inventor Thomas Netscher

Thomas Netscher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FORMATION OF CHROMANES BASED ON INTERMOLECULAR REACTION OF ALKYNES WITH DIMETHYLFURAN IN THE PRESENCE OF GOLD(I) COMPLEXES
    Publication number: 20170349563
    Abstract: The present invention relates to a method of preparing chromanes from 2,5-dimethylfuran and substituted alkynes comprising an long chain unsaturated alkyl group as substituent in the alpha position of a substituted phenol followed by oxidation, reduction and acid ring closure. It is particularly advantageous to use 2,5-dimethylfuran as this offers an ecological beneficial synthesis of ?-tocopherol.
    Type: Application
    Filed: December 9, 2015
    Publication date: December 7, 2017
    Inventors: Ulla LETINOIS, Thomas NETSCHER
  • Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of phenols or thiophenols
    Patent number: 9815809
    Abstract: The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific type and of at least one phenol or thiophenol.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: November 14, 2017
    Assignee: DSM IP ASSETS B.V.
    Inventors: Ulla Letinois, Thomas Netscher
  • Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of ureas or thioureas
    Patent number: 9809565
    Abstract: The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific type and of at least one urea or thiourea.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: November 7, 2017
    Assignee: DSM IP ASSETS B.V.
    Inventors: Ulla Letinois, Thomas Netscher, Stephan Ackermann
  • PROCESS OF PRODUCTION OF 7,8-DIHYDRO-C15-ALDEHYDE
    Publication number: 20170313654
    Abstract: The present invention relates to a new method to produce 7,8-dihydro-C15-aldehyde.
    Type: Application
    Filed: October 15, 2015
    Publication date: November 2, 2017
    Inventors: Werner BONRATH, Jan SCHUETZ, Thomas NETSCHER, Bettina WUESTENBERG
  • METHOD FOR PRODUCING SPECIFIC ALPHA,BETA-UNSATURATED ALDEHYDES BY REARRANGEMENT PROCESS
    Publication number: 20170313655
    Abstract: The present invention relates to an improved method for producing specific ?,?-unsaturated aldehydes.
    Type: Application
    Filed: October 15, 2015
    Publication date: November 2, 2017
    Inventors: Werner BONRATH, Jan SCHUETZ, Thomas NETSCHER, Bettina WUESTENBERG
  • METHOD FOR PRODUCING SPECIFIC ALPHA, BETA-UNSATURATED ALDEHYDES
    Publication number: 20170305827
    Abstract: The present invention relates to an improved method for producing specific ?, ?-unsaturated aldehydes.
    Type: Application
    Filed: October 15, 2015
    Publication date: October 26, 2017
    Inventors: Werner BONRATH, Thomas NETSCHER, Jan SCHUETZ, Bettina WUESTENBERG
  • ETHYNYLATION OF POLYUNSATURATED ALDEHYDES AND KETONES
    Publication number: 20170297984
    Abstract: The present invention relates to a catalytic process for the ethynylation of specific poly-unsaturated aldehydes and ketones.
    Type: Application
    Filed: October 15, 2015
    Publication date: October 19, 2017
    Inventors: Werner BONRATH, Jan SCHUETZ, Thomas NETSCHER, Bettina WUESTENBERG
  • (6R,10R)-6,10,14-trimetylpentadecan-2-one prepared from 6,10,14 trimetylpentadeca-5,9,13-trien-2-one or 6,10,14-trimetylpentadeca-5,9-dien-2-one
    Patent number: 9611200
    Abstract: The present invention relates to a process of manufacturing (6R,10R)-6,10,14-trimethylpentadecan-2-one in a multistep synthesis from a mixture of (5E,9E)-, (5E,9Z)-, (5Z,9E)- and (5Z.9Z)-isomers of 6,10,14-trimethylpentadeca-5,9,13-trien-2-one or 6,10,14-trimethylpentadeca-5,9-dien-2-one. The process is very advantageous in that it forms in an efficient way the desired chiral product from a mixture of stereoisomers of the starting product.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: April 4, 2017
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Thomas Netscher, Jonathan Alan Medlock, René Tobias Stemmler, Johannes Tschumi, Gerardus Karel Maria Verzijl, Andreas Hendrikus Maria De Vries
  • Using mixtures of E/Z isomers to obtain quantitatively specific products by combining asymmetric hydrogenation and isomerization
    Patent number: 9573872
    Abstract: The present invention relates to a process of manufacturing compound having stereogenic centers from a mixture of E/Z isomers of unsaturated compounds having prochiral double bonds. The hydrogenation product has a specific desired configuration at the stereogenic centers. The process involves an asymmetric hydrogenation and an isomerization step. The process is very advantageous in that it forms the desired chiral product from a mixture of stereoisomers of the starting product in an efficient way.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: February 21, 2017
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Thomas Netscher, Jonathan Alan Medlock, René Tobias Stemmler, Gerardus Karel Maria Verzijl, Andreas Hendrikus Maria De Vries
  • Process of asymmetric hydrogenation of ketals and acetals
    Patent number: 9561989
    Abstract: The present invention relates to a process of the asymmetric hydrogenation of a ketal of an unsaturated ketone or an acetal of an unsaturated aldehyde by molecular hydrogen in the presence of at least one chiral iridium complex. This process yields chiral compounds in a very efficient way and is very advantageous in that the amount of iridium complex can be remarkably reduced.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: February 7, 2017
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Thomas Netscher, Jonathan Alan Medlock, Gerardus Karel Maria Verzijl, Andreas Hendrikus Maria De Vries
  • PROCESS OF PRODUCTION OF 2,5-DIMETHYLPHENOL
    Publication number: 20170001935
    Abstract: The present invention relates to a new method to produce 2,5-dimethylphenol (2,5-DMP).
    Type: Application
    Filed: January 27, 2015
    Publication date: January 5, 2017
    Inventors: Werner BONRATH, Ulla LETINOIS, Thomas NETSCHER
  • Using mixtures of E/Z isomers to obtain quantitatively specific products by combined asymmetric hydrogenations
    Patent number: 9458076
    Abstract: The present invention relates to a process of manufacturing compound having stereogenic centers from a mixture of E/Z isomers of unsaturated compounds having prochiral double bonds. The hydrogenation product has a specific desired configuration at the stereogenic centers. The process involves two asymmetric hydrogenation steps. The process is very advantageous in that it forms the desired chiral product from a mixture of stereoisomers of the starting product in an efficient way.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: October 4, 2016
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Thomas Netscher, Jonathan Alan Medlock, René Tobias Stemmler, Gerardus Karel Maria Verzijl, Andreas Hendrikus Maria De Vries
  • (6R,10R)-6,10,14-trimetylpentadecan-2-one prepared from 6,10-dimetylundec-5-en-2-one or 6,10-dimetylundeca-5,9-dien-2-one
    Patent number: 9452961
    Abstract: The present invention relates to a process of manufacturing (6R,10R)-6,10,14-trimetylpentadecan-2-one in a multistep synthesis from 6,10-dimetylundec-5-en-2-one or 6,10-dimetylundeca-5,9-dien-2-one. The process is very advantageous in that it forms in an efficient way the desired chiral product from a mixture of stereoisomers of the starting product.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: September 27, 2016
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Thomas Netscher, Jonathan Alan Medlock, René Tobias Stemmler, Johannes Tschumi, Gerardus Karel Maria Verzijl, Andreas Hendrikus Maria De Vries
  • Process for the production of 4-alkanoyloxy-2-methylbutanoic acid
    Patent number: 9447017
    Abstract: The present invention relates to an improved process for the production of 4-alkanoyloxy-2-methylbutanoic acid, as well as to the use of such compounds in organic syntheses, especially in processes forming intermediates (building blocks) for the synthesis of organic compounds comprising isoprene (isoterpene) units, such as ?-carotene or other carotenoids (e.g. canthaxanthin, zeaxanthin or astaxanthin) or as vitamin E or vitamin A as well as other structurally similar compounds.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: September 20, 2016
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Jan Schütz, Bettina Wüstenberg, Thomas Netscher
  • USING MIXTURES OF E/Z ISOMERS TO OBTAIN QUANTITATIVELY SPECIFIC PRODUCTS BY COMBINING ASYMMETRIC HYDROGENATION AND ISOMERIZATION
    Publication number: 20160185702
    Abstract: The present invention relates to a process of manufacturing compound having stereogenic centres from a mixture of E/Z isomers of unsaturated compounds having prochiral double bonds. The hydrogenation product has a specific desired configuration at the stereogenic centres. The process involves an asymmetric hydrogenation and an isomerization step. The process is very advantageous in that it forms the desired chiral product from a mixture of stereoisomers of the starting product in an efficient way.
    Type: Application
    Filed: December 18, 2013
    Publication date: June 30, 2016
    Inventors: Werner BONRATH, Thomas NETSCHER, Jonathan Alan MEDLOCK, René Tobias STEMMLER, Gerardus Karel Maria VERZIJL, Andreas Hendrikus Maria DE VRIES
  • PROCESS OF ASYMMETRIC HYDROGENATION OF KETALS AND ACETALS
    Publication number: 20160185683
    Abstract: The present invention relates to a process of the asymmetric hydrogenation of a ketal of an unsaturated ketone or an acetal of an unsaturated aldehyde by molecular hydrogen in the presence of at least one chiral iridium complex. This process yields chiral compounds in a very efficient way and is very advantageous in that the amount of iridium complex can be remarkably reduced.
    Type: Application
    Filed: December 18, 2013
    Publication date: June 30, 2016
    Inventors: Werner BONRATH, Thomas NETSCHER, Jonathan Alan MEDLOCK, Gerardus Karel Maria VERZIJL, Andreas Hendrikus Maria DE VRIES
  • FORMATION OF CHIRAL 4-CHROMANONES USING CHIRAL PYRROLIDINES IN THE PRESENCE OF PHENOLS OR THIOPHENOLS
    Publication number: 20160168111
    Abstract: The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific type and of at least one phenol or thiophenol.
    Type: Application
    Filed: July 3, 2014
    Publication date: June 16, 2016
    Inventors: Ulla LETINOIS, Thomas NETSCHER
  • FORMATION OF CHIRAL 4-CHROMANONES USING CHIRAL PYRROLIDINES IN THE PRESENCE OF ACIDS
    Publication number: 20160168110
    Abstract: The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of a specific type and of at least one Bransted acid or in the presence a specific chiral compound having a Bransted acid functional group in the molecule.
    Type: Application
    Filed: July 3, 2014
    Publication date: June 16, 2016
    Inventors: Jonthan Alan MEDLOCK, Ulla LETINOIS, Thomas NETSCHER, Wemer BONRATH
  • FORMATION OF CHIRAL 4-CHROMANONES USING CHIRAL PYRROLIDINES IN THE PRESENCE OF UREAS OR THIOUREAS
    Publication number: 20160145228
    Abstract: The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific type and of at least one urea or thiourea.
    Type: Application
    Filed: July 3, 2014
    Publication date: May 26, 2016
    Applicant: DSM IP ASSETS B.V.
    Inventors: Ulla LETINOIS, Thomas NETSCHER, Stephan ACKERMANN
  • Intermediates for the vitamin A and ?-carotene synthesis
    Patent number: 9309194
    Abstract: The present invention relates to compounds of formula (I) wherein R1 signifies a C1-C15 alkyl moiety or a C2 to C18 alkenyl moiety, to their process of production as well as to their use in organic synthesis, especially as intermediates (building blocks) in the synthesis of vitamin A or ?-carotene or derivatives thereof, or other carotenoids, e.g. canthaxanthin, astaxanthin or zeaxanthin, preferably vitamin A.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: April 12, 2016
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Thomas Netscher, Jan Schütz, Bettina Wüstenberg