Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.

Abstract: Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R3, R4, R5, R6, R8, m and n are as defined herein. Such compounds modulate the opioid receptor, particulate the mu-opioid receptor (MOR) and/or the kappa-opioid receptor (KOR), and/or the delta-opioid receptor (DOR). Products containing such compounds, as well as methods for their use and preparation, are also provided.

Abstract: This disclosure describes techniques for configuring and managing scalable global private networks associated with a service provider. Different input mechanisms, such as an API, a UI, or a CLI may be utilized to configure, and manage a global private network that spans across the cloud in different geographic locations and connects to different stand-alone networks. The user may proactively use the input mechanisms to configure and query different network resources to reactively configure settings for reacting to one or more events. The input mechanisms may also be utilized to define the network resources to be modeled within the global private network as well as connections within the global network. A user may configure events/metrics to be monitored, tasks/workflows to be performed, and the like. In some configurations, a network management service (NMS) may perform health monitoring and reachability monitoring to identify possible issues in the global network.

Abstract: A method is provided for monitoring the occurrence of pressure anomalies due to FDI in near real time during a hydraulic fracturing operation carried out on an active well that is located near one or more passive monitoring wells. The method includes the steps of obtaining raw pressure sensor data from the one or more passive monitoring wells, processing the pressure sensor data with the FDI analysis module, and determining if the rate of change for averaged pressure sensor data exceeds a preset threshold value that indicates the likelihood of a pressure anomaly. The methods can be configured to autonomously alert an operator of the likelihood of a pressure anomaly and with guidance on resolving the anomalies.

Abstract: A pathogen detection device is provided. The pathogen detection device may include a pathogen detector circuit configured to detect a target analyte in a patient sample, determine the presence of a pathogen from the target analyte, and generate a detection result including the identity of the pathogen and resistance genes (if any); and a decision support generator circuit configured to generate decision support information for the pathogen by application of user configurable rules to the detection result, wherein each of the configurable rules include a logic expression that indicates the corresponding decision support information of the rule to be included in the detection report.

Abstract: Network pathways are identified to transfer packets between a pair of regional virtual traffic hubs of a provider network. At a first hub of the pair, a first action is performed, resulting in a transmission of a packet received from a first isolated network to the second hub along a pathway selected using dynamic routing parameters. At the second hub, a second action is performed, resulting in the transmission of the packet to a destination within a second isolated network.

Abstract: Network pathways are identified to transfer packets between a pair of regional virtual traffic hubs of a provider network. At a first hub of the pair, a first action is performed, resulting in a transmission of a packet received from a first isolated network to the second hub along a pathway selected using dynamic routing parameters. At the second hub, a second action is performed, resulting in the transmission of the packet to a destination within a second isolated network.

Abstract: At an action implementation layer of a virtual traffic hub, a packet is obtained from a first isolated network. A first action, generated at a decision making layer of the hub based on a first route table of the hub, is performed, resulting in transmission of at least one network packet to a first destination. In response to a second packet, obtained at the action implementation layer from a source outside the first isolated network, a second action is performed, resulting in transmission of at least one packet to a second destination. The second action is generated based on a second route table of the hub.

Abstract: At an action implementation layer of a virtual traffic hub, a packet is obtained from a first isolated network. A first action, generated at a decision making layer of the hub based on a first route table of the hub, is performed, resulting in transmission of at least one network packet to a first destination. In response to a second packet, obtained at the action implementation layer from a source outside the first isolated network, a second action is performed, resulting in transmission of at least one packet to a second destination. The second action is generated based on a second route table of the hub.

Abstract: Network pathways are identified to transfer packets between a pair of regional virtual traffic hubs of a provider network. At a first hub of the pair, a first action is performed, resulting in a transmission of a packet received from a first isolated network to the second hub along a pathway selected using dynamic routing parameters. At the second hub, a second action is performed, resulting in the transmission of the packet to a destination within a second isolated network.

Abstract: A delivery monitoring system comprises a portable camera positioned on a delivery person; a camera activation application executed by a mobile electronic device to control a video-generating operation of the portable camera; and a special-purpose processor that outputs a data instruction to an electronic locking device to unlock an entrance to a location for delivering an item by the delivery person only when the portable camera is recording video.

Abstract: A pathogen detection device is provided. The pathogen detection device may include a pathogen detector circuit configured to detect a target analyte in a patient sample, determine the presence of a pathogen from the target analyte, and generate a detection result including the identity of the pathogen and resistance genes (if any); and a decision support generator circuit configured to generate decision support information for the pathogen by application of user configurable rules to the detection result, wherein each of the configurable rules include a logic expression that indicates the corresponding decision support information of the rule to be included in the detection report.

Abstract: In one embodiment, a diagnostic system includes an instrument coupled to a client device and having at least one sample processing bay. The diagnostic system has a software architecture including instrument software (ISW) associated with the instrument. The ISW receives an assay definition file (ADF) that has a control file and an assay analysis module (AAM) file. The processing bay prepares and senses the sample according to parameters in the OPUS file and then generates sensor scan data. The diagnostic system then analyzes the sensor scan data and prepares a report according to the AAM file.

Abstract: In some examples, a Powered Device (PD) having dual Power over Ethernet (PoE) redundancy comprises a first PD chip to interact with a first PoE port comprised in a first Power Sourcing Equipment (PSE), a second PD chip to interact with a second PoE port comprised in a second PSE, a first control logic module to permit the first PD chip to independently interact with the first PoE port, a second control logic module to permit the second PD chip to independently interact with the second PoE port, a first Field Effect Transistor FET to turn on/off a first diode, the first FET being controlled by the first control logic module, a second FET to turn on/off a second diode, the second FET being controlled by the second control logic module. The first and the second diodes to combine the first and the second voltages from the first and the second PSE, respectively.

Abstract: A system and method to determine health prognostics for selection and management of a tool for deployment in a downhole environment are described. The system includes a database to store life cycle information of the tool, the life cycle information including environmental and operational parameters associated with use of the tool. The system also includes a memory device to store statistical equations to determine the health prognostics of the tool, and a processor to calibrate the statistical equations and build a time-to-failure model of the tool based on a first portion of the life cycle information in the database.

Abstract: One variation of a serving unit includes: a base; a wall extending from the base, including a frustoconical section, and defining a central axis; a rim extending from an upper edge of the wall; a seal extending across the rim and transiently enclosing a cavity defined by the wall and the base; a beater arranged within the cavity, configured to rotate about the central axis, including blades configured to extend along the base and up a portion of the wall, and including a drive coupling coaxial with the central axis; and a dry powdered food product arranged within the cavity and including a first quantity of flavoring, a second quantity of sweetener, and a third quantity of thickener.

Abstract: One variation of a method for preparing a frozen food product includes: following insertion of a vessel into a receiver: activating a cooling element thermally coupled to the receiver; transitioning a rotary motor from rest to a first target angular speed; and setting a first timer of a first duration; in response to expiration of the first timer and detection of contents of the vessel approximating a first target viscosity: reducing an angular speed of the rotary motor; and setting a second timer of a second duration; in response to expiration of the second timer and detection of the contents of the vessel approximating a second target viscosity: reducing the angular speed of the rotary motor; and setting a third timer of a third duration; in response to expiration of the third timer: reducing the angular speed of the rotary motor; and indicating completion of a frozen food product.

Abstract: A computer readable medium includes instructions which cause performance of operations to configure an access point, including receiving, by a wireless communication controller, wireless communication signals detected by a wireless communication antenna. The access point includes the wireless communication antenna, the wireless communication controller, and a System-On-Chip (SOC) having a serial port configured for receiving input from the wireless communication controller. The wireless communication signals include configuration commands. The operations further include generating, by the wireless communication controller, serial signals based on the wireless communication signals, the serial signals including the configuration commands.

Abstract: Cleaning a recording head slider in-drive during operation is accomplished by periodically performing a series of full stroke seek operations, whereby liquid contaminants that may have migrated to the head slider are flung from the slider and liquid from the disk surface may be adsorbed onto the slider for removal by way of flinging. Consequently, head-disk spacing may be stabilized and data write operations improved. Furthermore, the series of full stroke seek operations may be performed at predetermined intervals, and for a predetermined period of time. However, the series may be interrupted by a client request, and continued thereafter, so as not to affect the operational status of the recording system.

Abstract: The present invention provides a system that provides and extends wireless RF signals to any distance location beyond the normal transmission/broadcast of cellular tower utilizing a existing network. The system provides wireless communication carried by wire lines for communication and testing between remote locations in real-time.