Patents by Inventor Thomas Nieland

Thomas Nieland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thiazole-based inhibitors of scavenger receptor BI
    Patent number: 9951055
    Abstract: This application describes compounds and methods that can inhibit Scavenger receptor class B, type I (SR-BI) activity, which compounds and methods can used, for example, to mediate high-density lipoprotein (HDL) lipid uptake and treat hepatitis C viral infections.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: April 24, 2018
    Assignees: Massachusetts Institute of Technology, The Broad Institute, Inc.
    Inventors: Chris Dockendorff, Willmen Youngsaye, Partha Pratim Nag, Timothy A. Lewis, Sivaraman Dandapani, Benito Munoz, Patrick Faloon, Thomas Nieland, Monty Krieger, Miao Yu
  • Heterocycle-bisamide inhibitors of scavenger receptor BI
    Patent number: 9884851
    Abstract: This application describes compounds and methods that can inhibit Scavenger receptor class B, type I (SR-BI) activity, which compounds and methods can be used, for example, to mediate high-density lipoprotein (HDL) lipid uptake and treat hepatitis C viral infections. The compounds have the formula: wherein R1 and R2 are independently H, halogen, cyano, haloalkyl, haloalkyloxy or OMe; or R1 and R2 together are —O—CH2— or —O—CF2—O—; R3 is H, halogen, cyano, haloalkyl or haloalkyloxy; R4 is C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkylmethyl or C3-6cycloheteroalkyl, wherein the heteroatom is N or O; R5 is H or CH3; R6 is C1-6alkyl or C3-6cycloalkyl; and A, B, D and E are each, independently, CH, N, O or S, wherein at least one of A, B, D and E is N, and another of A, B, D and E is N, O or S.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: February 6, 2018
    Assignees: Massachusetts Institute Of Technology, The Broad Institute, Inc.
    Inventors: Chris Dockendorff, Andrew Germain, Partha Pratim Nag, Willmen Youngsaye, Sivaraman Dandapani, Benito Munoz, Patrick Faloon, Thomas Nieland, Monty Krieger, Miao Yu
  • THIAZOLE-BASED INHIBITORS OF SCAVENGER RECEPTOR BI
    Publication number: 20160060254
    Abstract: This application describes compounds and methods that can inhibit Scavenger receptor class B, type I (SR-BI) activity, which compounds and methods can used, for example, to mediate high-density lipoprotein (HDL) lipid uptake and treat hepatitis C viral infections.
    Type: Application
    Filed: October 21, 2013
    Publication date: March 3, 2016
    Inventors: Chris Dockendorff, Willmen Youngsaye, Partha Pratim Nag, Timothy A. Lewis, Sivaraman Dandapani, Benito Munoz, Patrick Falloon, Thomas Nieland, Monty Krieger, Miao Yu
  • HETEROCYCLE-BISAMIDE INHIBITORS OF SCAVENGER RECEPTOR BI
    Publication number: 20150284371
    Abstract: This application describes compounds and methods that can inhibit Scavenger receptor class B, type I (SR-BI) activity, which compounds and methods can be used, for example, to mediate high-density lipoprotein (HDL) lipid uptake and treat hepatitis C viral infections. The compounds have the formula: wherein R1 and R2 are independently H, halogen, cyano, haloalkyl, haloalkyloxy or OMe; or R1 and R2 together are —O—CH2— or -0- CF2—O—; R3 is H, halogen, cyano, haloalkyl or haloalkyloxy; R4 is C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkylmethyl or C3-6cycloheteroalkyl, wherein the heteroatom is N or 0; R5 is H or CH3; R6 is C1-6alkyl or C3-6cycloalkyl; and A, B, D and E are each, independently, CH, N, 0 or S, wherein at least one of A, B, D and E is N, and another of A, B, D and E is N, 0 or S.
    Type: Application
    Filed: October 21, 2013
    Publication date: October 8, 2015
    Inventors: Chris Dockendorff, Andrew Germain, Partha Pratim Nag, Willmen Youngsaye, Sivaraman Dandapani, Benito Munoz, Patrick Falloon, Thomas Nieland, Monty Krieger, Miao Yu