Patents by Inventor Thomas NUTMAN

Thomas NUTMAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunogenic compositions and vaccines for preventing or treating filarial disease
    Patent number: 10441642
    Abstract: The present disclosure is directed to an immunogenic composition including: at least one or at least two isolated polypeptides or immunogenic fragments thereof, and optionally a pharmaceutically acceptable carrier, wherein each polypeptide is expressed on a luminal surface of an intestine of a filarial worm, wherein each polypeptide is expressed at a level at least two-fold higher in the intestine in comparison to the level of expression of each polypeptide in a reproductive tract or a body wall of the filarial worm, wherein each isolated polypeptide has at least one transmembrane domain, and wherein each polypeptide is a non-mitochondrial polypeptide. Also provided herein is a method for preventing or treating a filarial disease.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: October 15, 2019
    Assignees: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., The United States Government, as Represented by the Secretary of the Department of Health and Human Services
    Inventors: Edward E. Mitre, Christopher Morris, Sasisekhar Bennuru, Thomas Nutman
  • IMMUNOGENIC COMPOSITIONS AND VACCINES FOR PREVENTING OR TREATING FILARIAL DISEASE
    Publication number: 20180064791
    Abstract: The present disclosure is directed to an immunogenic composition including: at least one or at least two isolated polypeptides or immunogenic fragments thereof, and optionally a pharmaceutically acceptable carrier, wherein each polypeptide is expressed on a luminal surface of an intestine of a filarial worm, wherein each polypeptide is expressed at a level at least two-fold higher in the intestine in comparison to the level of expression of each polypeptide in a reproductive tract or a body wall of the filarial worm, wherein each isolated polypeptide has at least one transmembrane domain, and wherein each polypeptide is a non-mitochondrial polypeptide. Also provided herein is a method for preventing or treating a filarial disease.
    Type: Application
    Filed: March 17, 2016
    Publication date: March 8, 2018
    Inventors: Edward E. MITRE, Christopher MORRIS, Sasisekhar BENNURU, Thomas NUTMAN