Patents by Inventor Thomas O. Linden

Thomas O. Linden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ON-COLUMN REFOLDING AND PURIFYING OF LIPOPROTEINS
    Publication number: 20150307591
    Abstract: Provided are methods of refolding and purifying lipoproteins on a chromatography column. In particular methods of refolding ApoL1 polypeptides using a hydrophobic interaction column (HIC). The present invention provides methods for the purification of an active form of a human lipoprotein, such as ApoL1. More particularly, the present invention relates to a method for renaturing an inclusion body of proteins expressed in a large quantity in E. coli into an active form using a hydrophobic interaction column and removal of impurities, e.g., endotoxins.
    Type: Application
    Filed: December 19, 2013
    Publication date: October 29, 2015
    Applicant: MERCK SHARP & DOHME CORP.
    Inventors: Rebecca A. Chmielowski, Collette Cutler, Hong Li, Thomas O. Linden