Patents by Inventor Thomas O'Shea

Thomas O'Shea has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETING HOMOLOGOUS RECOMBINATION: A NEW SYTHETIC LETHAL THERAPEUTIC PARADIGM
    Publication number: 20210275503
    Abstract: This application is directed to inhibitors of RAD51 represented by the following structural formula, and methods for its use, such as to treat cancer.
    Type: Application
    Filed: March 3, 2021
    Publication date: September 9, 2021
    Inventors: Thomas O'SHEA, Markus RENSCHLER, Todd BOWSER, Jean-Marc LAPIERRE, Kevin MILLS
  • GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
    Publication number: 20210261557
    Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
    Type: Application
    Filed: April 27, 2021
    Publication date: August 26, 2021
    Applicant: GENZYME CORPORATION
    Inventors: Elyse BOURQUE, Mario CABRERA-SALAZAR, Cassandra CELATKA, Seng CHENG, Mary A. CROMWELL, Andrew GOOD, Bradford HIRTH, Katherine JANCSICS, John P. LEONARD, Lingyun LI, James LILLIE, Hanlan LIU, Elina MAKINO, John MARSHALL, Paul MASON, Markus METZ, Fazeela MORSHED, Thomas O'SHEA, Ronald SCHEULE, Renato SKERLJ, Bing WANG, Yibin XIANG, Zhong ZHAO
  • GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
    Publication number: 20200048266
    Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
    Type: Application
    Filed: August 15, 2019
    Publication date: February 13, 2020
    Inventors: Elyse BOURQUE, Mario CABRERA-SALAZAR, Cassandra CELATKA, Seng CHENG, Mary A. CROMWELL, Andrew GOOD, Bradford HIRTH, Katherine JANCSICS, John P. LEONARD, Lingyun LI, James LILLIE, Hanlan LIU, Elina MAKINO, John MARSHALL, Paul MASON, Markus METZ, Fazeela MORSHED, Thomas O'SHEA, Ronald SCHEULE, Renato SKERLJ, Bing WANG, Yibin XIANG, Zhong ZHAO
  • Immunomodulatory peptides and methods of use thereof
    Patent number: 10550171
    Abstract: The present disclosure provides peptides that modulate an immune response in an individual. The present disclosure provides peptides that modulate cellular responses in vitro. The present disclosure provides compositions comprising the peptides. The peptides and compositions are useful in methods of modulating an immune response in an individual, which methods are also provided.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: February 4, 2020
    Assignee: The Governors of the University of Alberta
    Inventors: Adrian Egli, Deanna Michelle Santer, Aviad Yaagov Levin, Bradley Scott Thomas, Khaled Hassan Sayed Barakat, Michael A. Joyce, Daire Thomas O'Shea, Rakesh Kumar Bhat, Michael Houghton, D. Lorne J. Tyrrell, Atul Humar, Deepali Kumar
  • GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
    Publication number: 20160207933
    Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
    Type: Application
    Filed: August 25, 2015
    Publication date: July 21, 2016
    Inventors: Elyse BOURQUE, Mario CABRERA-SALAZAR, Cassandra CELATKA, Seng CHENG, Mary A. CROMWELL, Andrew GOOD, Bradford HIRTH, Katherine JANCSICS, John P. LEONARD, Lingyun LI, James LILLIE, Hanlan LIU, Elina MAKINO, John MARSHALL, Paul MASON, Markus METZ, Fazeela MORSHED, Thomas O'SHEA, Ronald SCHEULE, Renato SKERLJ, Bing WANG, Yibin XIANG, Zhong ZHAO
  • IMMUNOMODULATORY PEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20150307590
    Abstract: The present disclosure provides peptides that modulate an immune response in an individual. The present disclosure provides peptides that modulate cellular responses in vitro. The present disclosure provides compositions comprising the peptides. The peptides and compositions are useful in methods of modulating an immune response in an individual, which methods are also provided.
    Type: Application
    Filed: November 21, 2013
    Publication date: October 29, 2015
    Inventors: Adrian Egli, Deanna Michelle Santer, Aviad Yaagov Levin, Bradley Scott Thomas, Khaled Hassan Sayed Barakat, Michael A. Joyce, Daire Thomas O'Shea, Rakesh Kumar Bhat, Michael Houghton, D. Lorne J. Tyrrell, Atul Humar, Deepali Kumar
  • Glucosylceramide synthase inhibitors
    Patent number: 9139580
    Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: September 22, 2015
    Assignee: Genzyme Corporation
    Inventors: Elyse Bourque, Bradford Hirth, Renato Sklerj, Elina Makino, Fazeela Morshed, Lingyun Li, Paul Mason, John P. Leonard, James Lillie, Hanlan Liu, Mary A. Cromwell, Bing Wang, Thomas O'Shea
  • Glucosylceramide synthase inhibitors
    Patent number: 9126993
    Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: September 8, 2015
    Assignee: Genzyme Corporation
    Inventors: Elyse Bourque, Bradford Hirth, Renato Sklerj, Elina Makino, Fazeela Morshed, Lingyun Li, Paul Mason, John P. Leonard, James Lillie, Hanlan Liu, Mary A. Cromwell, Bing Wang, Thomas O'Shea
  • Process for low density additive flexible circuits and harnesses
    Patent number: 5721007
    Abstract: An additive electrical circuit (5) on a flexible substrate (1) fabricated by; metallization of the substrate, applying a mask pattern comprising a plating resistant material, applying a conductive circuit material in a circuit pattern that is uncovered by the mask pattern, and removing the plating resistant material and the metallization. Leaving the circuit (5) on the substrate (1) to be applied as a harness or instrument panel.
    Type: Grant
    Filed: April 25, 1995
    Date of Patent: February 24, 1998
    Assignee: The Whitaker Corporation
    Inventors: Thomas J. Lynch, Ram K. Agnihotri, Paul F. Engle, Roger T. Banks, Ronald B. Barnes, Earl Hennenhoefer, Russell T. Lerch, Thomas O'Shea, John Yavor