Patents by Inventor Thomas P. Dooley

Thomas P. Dooley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6229001
    Abstract: The invention relates to the nucleic acid sequence and amino acid sequence of dihydrofolate reductase (DHFR) from mycobacteria and to expression of recombinant DHFR protein. Utilizing the recombinant protein, novel therapies and diagnostic strategies can be developed and selective antimycobacterial compositions can be designed and utilized to treat mycobacterial infections in patients. This invention includes all or portions of novel recombinant nucleic acids encoding DHFR for mycobacteria such as M. avium, to novel recombinant DHFR peptides produced by such sequences, and to vaccines, diagnostic kits, cells and therapies utilizing these peptides and nucleic acid sequences. The present invention relates to methods for using the sequences of the present invention to develop drugs specific to M. avium and other mycobacteria, to identify and sequence corresponding sequences in species other than M. avium, as well as diagnostic and treatment methods incorporating the disclosed sequences and peptides.
    Type: Grant
    Filed: December 15, 1997
    Date of Patent: May 8, 2001
    Assignee: Southern Research Institute
    Inventors: William W. Barrow, Sabrina Z. Van Ginkel, Thomas P. Dooley, William J. Suling
  • Patent number: 5910424
    Abstract: A cell line of metastatic, pigmented, malignant melanoma cells made by exposing a litter of Monodelphis domestica suckling young to an accumulated dose of ultraviolet radiation and then continuing the ultraviolet exposure after the young are weaned to induce malignant melanoma tumors and culturing the tumor cells from lymph nodes. This cell line can be used to test anti-cancer agents in vitro. Further this cell line can be injected into Monodelphis domestica suckling young so that tumors develop in the animals, and the anti-cancer agents can be tested in vivo.
    Type: Grant
    Filed: December 3, 1997
    Date of Patent: June 8, 1999
    Assignee: Southwest Foundation for Biomedical Research
    Inventors: Thomas P. Dooley, Edward S. Robinson
  • Patent number: 5869332
    Abstract: A cell line of metastatic, pigmented, malignant melanoma cells made by exposing a litter of Monodelphis domestica suckling young to an accumulated dose of ultraviolet radiation and then continuing the ultraviolet exposure after the young are weaned to induce malignant melanoma tumors and culturing the tumor cells from lymph nodes. This cell line can be used to test anti-cancer agents in vitro. Further this cell line can be injected into Monodelphis domestica suckling young so that tumors develop in the animals, and the anti-cancer agents can be tested in vivo.
    Type: Grant
    Filed: June 3, 1994
    Date of Patent: February 9, 1999
    Assignee: Southwest Foundation for Biomedical Research
    Inventors: Thomas P. Dooley, Edward S. Robinson
  • Patent number: 5424192
    Abstract: This invention is directed to the identification, isolation and use of nonprostate derived markers, such as markers derived from the seminal vesicles, and antibodies which recognize these markers in the diagnosis of invasive proatic neoplasia, to diagnostic aids for screening biological samples for evidence of invasive prostatic neoplasia, and to methods for the use of these diagnostic aids.
    Type: Grant
    Filed: March 29, 1993
    Date of Patent: June 13, 1995
    Assignee: Baylor College of Medicine
    Inventors: Timothy C. Thompson, Thomas P. Dooley