Abstract: Provided are PROTACs comprised of a targeting moiety designed to bind KRAS (G12D) linked to a degrader-directing moiety designed to bind an E3 ubiquitin-ligase. Pharmaceutical compositions comprising the disclosed PROTACs and their use in treating cancer and related conditions are also provided.

Abstract: A golf game system is provided, including at least one ball, at least one club and at least one hole area. The club has a striking sensor for sensing a striking action of the club on the ball, and a score display for displaying a score related to the striking action. The hole area has a tee for placing the ball and a hole for receiving the ball, wherein the hole has a ball-in-the-hole sensor for communicating with the club. Scores are automatically printed for players at game conclusion, and club scores are erased to allow reuse by subsequent players.

Abstract: A golf game system is provided, including at least one ball, at least one club and at least one hole area. The club has a striking sensor for sensing a striking action of the club on the ball, and a score display for displaying a score related to the striking action. The hole area has a tee for placing the ball and a hole for receiving the ball, wherein the hole has a ball-in-the-hole sensor for communicating with the club. Scores are automatically printed for players at game conclusion.

Abstract: A golf game system is provided, including at least one ball, at least one club and at least one hole area. The club has a striking sensor for sensing a striking action of the club on the ball, and a score display for displaying a score related to the striking action. The hole area has a tee for placing the ball and a hole for receiving the ball, wherein the hole has a ball-in-the-hole sensor for communicating with the club. Scores are automatically printed for players at game conclusion, and club scores are erased to allow reuse by subsequent players.

Abstract: A golf game system is provided, including at least one ball, at least one club and at least one hole area. The club has a striking sensor for sensing a striking action of the club on the ball, and a score display for displaying a score related to the striking action. The hole area has a tee for placing the ball and a hole for receiving the ball, wherein the hole has a ball-in-the-hole sensor for communicating with the club. Scores are automatically printed for players at game conclusion.

Abstract: A golf game system is provided, including at least one ball, at least one club and at least one hole area. The club has a striking sensor for sensing a striking action of the club on the ball, and a score display for displaying a score related to the striking action. The hole area has a tee for placing the ball and a hole for receiving the ball, wherein the hole has a ball-in-the-hole sensor for communicating with the club. Scores are automatically printed for players at game conclusion.

Abstract: A golf game uses radio signals from golf balls to signal to a central computer for automatic score-keeping by the computer. Sensors in each hole also send signals to the computer on the completion of each hole play for each golfer. The golf balls are distinguishable by the computer according to their radio frequencies or digital or other signal processing and coding encoding. The golf balls transmit struck by special golf clubs which incorporate magnets; the balls include magnetic or other corresponding sensors. Each player, upon starting the game, inputs his/her name or initials which action identifies the specific ball he/she has been assigned use on the course. Scores are reported optionally at each hole, and a final score is reported by the computer at the conclusion of play.

Abstract: A golf game uses radio signals from golf clubs to signal to a central computer for automatic score-keeping by the computer. Sensors in each hole also send signals to the computer on the completion of each hole play for each golfer. The golf clubs are distinguishable by the computer according to their radio frequencies or digital or other signal processing and coding encoding. The golf clubs include transmitters in their handles which emit radio signals when the clubs are struck against preferably special golf balls, which incorporate magnets or other sensed qualities in their structure; the clubs include magnetic or other corresponding sensors. Each player, upon starting the game, inputs his/her name or initials along with an identification of the specific club he/she has selected to use on the course. Scores are reported optionally at each hole, and a final score is reported by the computer at the conclusion of play.

Abstract: This invention is directed to an automated mini-golf game having a plurality of mini-golf holes which each have a tee area, a fairway or putting green and at least one target hole. The final mini-golf hole of the game has a coin and bill acceptor for delivering a golf ball to a player when actuated, a target area with target holes at an elevated end of a ramp, and a switch and dispensing device for identifying which target hole through which a golf ball has been putted, and thereafter dispensing redemption coupons corresponding to such hole. The final hole also has a set of racks on its housing to hold scorecards, pencils and golf clubs, thereby permitting an entire game to be played sequentially by a multitude of players without an on-site attendant.

Abstract: A vacuum chuck apparatus includes a vacuum chuck mounted on one end of a hollow shaft whose other end is connected through a rotary seal to a vacuum source. The seal includes a first member having a cap portion cemented to the shaft end and an axially bored frustoconical projection on its end wall and a second member having a frustoconical socket complementing the projection which partially nests in the socket. The second member has a radial pin loosely engaging a longitudinal slot in a stationary bracket to restrict its rotation and permit its axial movement. A spring loaded pressure plate bears on the outer end face of the seal second member.

Abstract: A portable device for storing information as well as printing and dispensing multiple part tickets, such as traffic or parking violations tickets, includes a manually operable arrangement, for selecting and feeding a ticket from a stacked source of ticket stock, thus significantly reducing the energy requirements for operability and permitting portable usage of the device.

Abstract: A blower motor providing vacuum as, for example, for a magnetic tape handler, is programmed to provide a constant vacuum in an environment of changing altitudes. The blower motor is controlled by a pressure transducer which speeds up the motor as the altitude is increased and slows down the motor as the altitude is decreased.

Abstract: A high-speed printer includes a standard printing element, such as a daisy wheel, a paper feed mechanism and a ribbon feed mechanism. All of these various devices are controlled by a single linear actuator which comprises an elongated cylindrical magnet, C-shaped in cross-section, through which a ferrous core axially extends. A plurality of separate armatures envelope the core in the air gap between the magnet and core and are adapted to move linearly upon application thereto of a control current. The armatures control, respectively, the movement of the carriage containing the printer element, the rotation of the printer element, the advancement of the paper feed mechanism and the incremental positioning in both directions of the ink ribbon.

Abstract: A door lock security system is disclosed in which each lock in a multiple lock system is modified by the addition of door lock security apparatus which, in electrical form, stores at least an individual key combination (and possibly several different levels of master key combinations) for the lock. Also, the conventional lock cylinder is replaced with a cylinder assembly which senses the magnetic reluctance state (high or low) of predetermined locations on a key substantially resembling a conventional cylinder lock key in size, weight and general shape and capable of mechanically operating the lock. The magnetic reluctance states of the predetermined locations digitally encode the key combination and the thus encoded combination is compared to the electrically stored one, disabling the mechanical operation of the lock unless the two combinations are identical.

Abstract: A one piece extrusion provides the base for a simple and effective vacuum tank for magnetic tape handlers. The extrusion carries longitudinal slots which accept stamped metal nuts. These nuts are readily positioned by sliding them along the slots. Slots along the edges of the extrusion are used to carry nuts holding hinges for a plastic cover over the tank front. Slots along the back and near the edges of the extrusion carry nuts for mounting the tank on the tape handler main frame. A longitudinal slot along the back of the extrusion and spaced in from one edge carries spring-loaded tubular inserts for attachment to the vacuum sensing tubes. Communication with the vacuum chamber is implemented by means of holes at appropriate places along the body of the extrusion.

Abstract: The vacuum for controlling tape loop tension in a magnetic tape handler is supplied by a low speed multiple stage vacuum blower and controlled by a low power solenoid and a flapper valve operated between two predetermined positions. In order to provide fast operation of the flapper valve in response to the low power solenoid a fast acting fluid amplifier is utilized between the solenoid and the flapper valve. The elimination of belts, gears and high speed blowers results in an unusually quiet system.