Patents by Inventor Thomas P. Fraher

Thomas P. Fraher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid-state forms of N-(2-hydroxyacetyl)-5-(4-piperidyl)-4-(4-pyrimidinyl)-3-(4-chlorophenyl) pyrazole
    Patent number: 6872725
    Abstract: Crystalline forms of the p38 kinase inhibitor N-(2-hydroxyacetyl)-5-(4-piperidyl)-4-(4-pyrimidinyl)-3-(4-chlorophenyl)pyrazole are provided. These crystalline forms include (a) a first anhydrous crystalline form possessing improved physical stability relative to other solid-state forms of the compound; (b) a second anhydrous crystalline form possessing unique properties relative to other solid-state forms of the compound; (c) a third anhydrous crystalline form possessing unique properties relative to other solid-state forms of the compound; and (d) solvated crystalline forms, hydrated crystalline forms, and crystalline salt forms of the compound that are useful, for example, as intermediate solid-state forms in the preparation of other crystalline forms of the compound.
    Type: Grant
    Filed: September 25, 2002
    Date of Patent: March 29, 2005
    Assignee: Pharmacia Corporation
    Inventors: Kimberley C. Allen, Jerry D. Clark, Thomas P. Fraher, Jason A. Hanko, Kimberly L. Kolbert, Clay R. Little, Michael K. Mao, Patricia S. Miyake, Jodi L. Moe, Partha S. Mudipalli, Tobin C. Schilke, Christine B. Seymour, Ahmad Y. Sheikh, Gopichand Yalamanchili
  • Novel pyrazoles and their use as p38 kinase inhibitors
    Publication number: 20040082551
    Abstract: This invention is directed generally to pyrazoles that, inter alia, inhibit p38 kinase, TNF, and/or cyclooxygenase-2 activity.
    Type: Application
    Filed: June 5, 2003
    Publication date: April 29, 2004
    Inventors: Alan G. Benson, Thomas P. Fraher, Michael E. Hepperle, Kevin D. Jerome, Win Naing, Shaun R. Selness, John K. Walker
  • Solid-state forms of N-(2-hydroxyacetyl)-5-(4-piperidyl)-4-(4-pyrimidinyl)-3-(4-chlorophenyl) pyrazole
    Publication number: 20030153583
    Abstract: Crystalline forms of the p38 kinase inhibitor N-(2-hydroxyacetyl)-5-(4-piperidyl)-4-(4-pyrimidinyl)-3-(4-chlorophenyl)pyrazole are provided. These crystalline forms include (a) a first anhydrous crystalline form possessing improved physical stability relative to other solid-state forms of the compound; (b) a second anhydrous crystalline form possessing unique properties relative to other solid-state forms of the compound; (c) a third anhydrous crystalline form possessing unique properties relative to other solid-state forms of the compound; and (d) solvated crystalline forms, hydrated crystalline forms, and crystalline salt forms of the compound that are useful, for example, as intermediate solid-state forms in the preparation of other crystalline forms of the compound.
    Type: Application
    Filed: September 25, 2002
    Publication date: August 14, 2003
    Inventors: Kimberley C. Allen, Jerry D. Clark, Thomas P. Fraher, Jason A. Hanko, Kimberly L. Kolbert, Clay R. Little, Michael K. Mao, Patricia S. Miyake, Jodi L. Moe, Partha S. Mudipalli, Tobin C. Schilke, Christine B. Seymour, Ahmad Y. Sheikh, Gopichand Yalamanchili
  • Chiral-&bgr;-amino acid compounds and derivatives thereof
    Patent number: 6172256
    Abstract: The present invention is directed to a method for the preparation of a chiral &bgr;-amino ester of the formula wherein R is lower alkyl; and X and Y are the same or different Cl, Br or I.
    Type: Grant
    Filed: March 3, 1999
    Date of Patent: January 9, 2001
    Assignee: G.D. Searle & Co.
    Inventors: James W. Malecha, Thomas P. Fraher