Patents by Inventor Thomas P. J. Garrett

Thomas P. J. Garrett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Structure of the insulin receptor ectodomain
    Patent number: 8301398
    Abstract: The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the closely-related insulin-like growth factor receptors or variants thereof.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: October 30, 2012
    Assignee: Walter and Eliza Hall Institute of Medical Research
    Inventors: Thomas P. J. Garrett, Timothy Edward Adams, George Lovrecz, Neil Moreton McKern, Michael Colin Lawrence, Lindsay Gale Sparrow, Colin Wesley Ward, Meizhen Lou, Victor Strelstov
  • Structure of the Insulin Receptor Ectodomain
    Publication number: 20100267927
    Abstract: The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the closely-related insulin-like growth factor receptors or variants thereof.
    Type: Application
    Filed: June 22, 2007
    Publication date: October 21, 2010
    Inventors: Thomas P.J. Garrett, Timothy Edward Admas, George Lovrecz, Neil Moreton McKern, Michael Colin Lawrence, Lindsay Gale Sparrow, Colin Wesley Ward, Meizhen Lou, Victor Strelstov
  • Fc receptor modulators and uses thereof
    Patent number: 7553809
    Abstract: This invention relates to a method of inhibiting Fc receptor binding of immunoglobulin including the use of a Fc receptor modulating compound which binds to defined surfaces on a Fc receptor. The present invention also relates to a method for treating a variety of diseases using a Fc receptor modulating compound.
    Type: Grant
    Filed: June 3, 2004
    Date of Patent: June 30, 2009
    Assignee: Ilexus Pty Limited
    Inventors: Jonathan B. Baell, Thomas P. J. Garrett, P. Mark Hogarth, Barry R. Matthews, Thomas D. McCarthy, Geoffrey A. Pietersz, Maree S. Powell, Ian F. C. McKenzie, Kelly F. Maxwell, Vidana Epa
  • Fc receptor modulators and uses thereof
    Patent number: 6835753
    Abstract: Methods for inhibiting Fc receptor binding of immunoglobulin in a patient comprising administering pharmaceutical compositions comprising Fc modulating compounds are disclosed.
    Type: Grant
    Filed: November 26, 2001
    Date of Patent: December 28, 2004
    Assignee: Ilexus Pty Limited
    Inventors: Jonathan B. Baell, Thomas P. J. Garrett, P. Mark Hogarth, Barry R. Matthews, Thomas D. McCarthy, Geoffrey A. Pietersz
  • Three dimensional structures and models of Fc receptors and uses thereof
    Publication number: 20040054480
    Abstract: Disclosed are crystals, crystal structure Fc&ggr;RIIa protein, three dimensional coordinates of Fc&ggr;RIIa protein, and structures and models derived from the Fc&ggr;RIIa structure. Also disclosed are crystals of Fc&egr;RI protein and three dimensional coordinates of Fc&egr;RI protein monomers and dimers derived from the Fc&ggr;RIIa structure. Also disclosed are three dimensional coordinates of Fc&ggr;RIIIb proteins and models of Fc&ggr;RIIIb derived from the Fc&ggr;RIIa structure. The present invention also includes methods to produce such crystals, crystal structures and models. Uses of such crystals, crystal structures and models are also disclosed, including structure based drug design and therapeutic compositions.
    Type: Application
    Filed: October 15, 2003
    Publication date: March 18, 2004
    Applicant: Ilexus Pty Limited
    Inventors: P. Mark Hogarth, Maree S. Powell, Ian F.C. McKenzie, Kelly F. Maxwell, Thomas P.J. Garrett, Vidana Epa
  • Structure-based identification of candidate compounds using three dimensional structures and models of Fc receptors
    Patent number: 6675105
    Abstract: Disclosed are crystals, crystal structure Fc&ggr;RIIa protein, three dimensional coordinates of Fc&ggr;RIIa protein, and structures and models derived from the Fc&ggr;RIIa structure. Also disclosed are crystals of Fc&egr;RI protein and three dimensional coordinates of Fc&egr;RI protein monomers and dimers derived from the Fc&ggr;RIIa structure. Also disclosed are three dimensional coordinates of Fc&ggr;RIIIb proteins and models of Fc&ggr;RIIIb derived from the Fc&ggr;RIIa structure. The present invention also includes methods to produce such crystals, crystal structures and models. Uses of such crystals, crystal structures and models are also disclosed, including structure based drug design and therapeutic compositions.
    Type: Grant
    Filed: February 5, 1999
    Date of Patent: January 6, 2004
    Assignee: Ilexus Pty Limited
    Inventors: P. Mark Hogarth, Maree S. Powell, Ian F. C. McKenzie, Kelly F. Maxwell, Thomas P. J. Garrett, Vidana Epa
  • THREE DIMENSIONAL STRUCTURES AND MODELS OF FC RECEPTORS AND USES THEREOF
    Publication number: 20020107359
    Abstract: Disclosed are crystals, crystal structure Fc&ggr;RIIa protein, three dimensional coordinates of Fc&ggr;RIIa protein, and structures and models derived from the Fc&ggr;RIIa structure. Also disclosed are crystals of Fc&egr;RI protein and three dimensional coordinates of Fc&egr;RI protein monomers and dimers derived from the Fc&ggr;RIIa structure. Also disclosed are three dimensional coordinates of Fc&ggr;RIIIb proteins and models of Fc&ggr;RIIIb derived from the Fc&ggr;RIIa structure. The present invention also includes methods to produce such crystals, crystal structures and models. Uses of such crystals, crystal structures and models are also disclosed, including structure based drug design and therapeutic compositions.
    Type: Application
    Filed: February 5, 1999
    Publication date: August 8, 2002
    Inventors: P. MARK HOGARTH, MAREE S. POWELL, IAN F.C. MCKENZIE, KELLY F. MAXWELL, THOMAS P.J. GARRETT, VIDANA EPA
  • Fc receptor modulators and uses thereof
    Publication number: 20020061844
    Abstract: This invention relates to a pharmaceutical composition comprising a Fc receptor modulating compound and a pharmaceutically acceptable carrier. The present invention also relates to a method for treating a variety of diseases using a Fc receptor modulating compound.
    Type: Application
    Filed: November 26, 2001
    Publication date: May 23, 2002
    Applicant: Ilexus Pty Limited
    Inventors: Jonathan B. Baell, Thomas P.J. Garrett, P. Mark Hogarth, Barry R. Matthews, Thomas D. McCarthy, Geoffrey A. Pietersz
  • Fc receptor modulators and uses thereof
    Patent number: 6355683
    Abstract: This invention relates to a pharmaceutical composition comprising a Fc receptor modulating compound and a pharmaceutically acceptable carrier. The present invention also relates to a method for treating a variety of diseases using a Fc receptor modulating compound.
    Type: Grant
    Filed: September 10, 1999
    Date of Patent: March 12, 2002
    Assignee: Ilexus Pty Limited
    Inventors: Jonathan B. Baell, Thomas P. J. Garrett, P. Mark Hogarth, Barry R. Matthews, Thomas D. McCarthy, Geoffrey A. Pietersz