Patents by Inventor Thomas P. Loisel

Thomas P. Loisel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bone delivery conjugates and method of using same to target proteins to bone
    Patent number: 11248021
    Abstract: A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dn is a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: February 15, 2022
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Philippe Crine, Guy Boileau, Isabelle Lemire, Thomas P. Loisel
  • BONE DELIVERY CONJUGATES AND METHOD OF USING SAME TO TARGET PROTEINS TO BONE
    Publication number: 20190119323
    Abstract: A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dn is a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.
    Type: Application
    Filed: December 28, 2018
    Publication date: April 25, 2019
    Inventors: Philippe CRINE, Guy BOILEAU, Isabelle LEMIRE, Thomas P. LOISEL
  • Bone delivery conjugates and method of using same to target proteins to bone
    Patent number: 10000532
    Abstract: A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dn is a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: June 19, 2018
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Philippe Crine, Guy Boileau, Isabelle Lemire, Thomas P. Loisel
  • BONE DELIVERY CONJUGATES AND METHOD OF USING SAME TO TARGET PROTEINS TO BONE
    Publication number: 20160052968
    Abstract: A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dn is a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.
    Type: Application
    Filed: November 3, 2015
    Publication date: February 25, 2016
    Inventors: Philippe CRINE, Guy Boileau, Isabelle Lemire, Thomas P. Loisel
  • Bone delivery conjugates and method of using same to target proteins to bone
    Patent number: 7960529
    Abstract: A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dn is a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: June 14, 2011
    Assignee: Enobia Pharma Inc.
    Inventors: Philippe Crine, Guy Boileau, Isabelle Lemire, Thomas P. Loisel
  • BONE TARGETED ALKALINE PHOSPHATASE, KITS AND METHODS OF USE THEREOF
    Publication number: 20100297119
    Abstract: A bone targeted alkaline phosphatase comprising a polypeptide having the structure: Z-sALP-Y-spacer-X-Wn-V, wherein sALP is the extracellular domain of the alkaline phosphatase; wherein V is absent or is an amino acid sequence of at least one amino acid; X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Wn is a polyaspartate or a polyglutamate wherein n=10 to 16. Kits and methods of use thereof.
    Type: Application
    Filed: May 12, 2008
    Publication date: November 25, 2010
    Inventors: Philippe Crine, Guy Boileau, Thomas P. Loisel, Isabelle Lemire, Pierre Léonard, Robert Heft, Hal Landy
  • BONE DELIVERY CONJUGATES AND METHOD OF USING SAME TO TARGET PROTEINS TO BONE
    Publication number: 20100240125
    Abstract: A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dn is a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.
    Type: Application
    Filed: June 3, 2010
    Publication date: September 23, 2010
    Applicant: Enobia Pharma Inc.
    Inventors: Philippe CRINE, Guy Boileau, Isabelle Lemire, Thomas P. Loisel
  • BONE DELIVERY CONJUGATES AND METHOD OF USING SAME TO TARGET PROTEINS TO BONE
    Publication number: 20100221234
    Abstract: A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dn is a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.
    Type: Application
    Filed: December 15, 2009
    Publication date: September 2, 2010
    Applicant: Enobia Pharma Inc.
    Inventors: Philippe CRINE, Guy Boileau, Isabelle Lemire, Thomas P. Loisel
  • Bone delivery conjugates and method of using same to target proteins to bone
    Patent number: 7763712
    Abstract: A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dn is a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.
    Type: Grant
    Filed: April 21, 2005
    Date of Patent: July 27, 2010
    Assignee: Enobia Pharma Inc.
    Inventors: Philippe Crine, Guy Boileau, Isabelle Lemire, Thomas P. Loisel