Patents by Inventor Thomas P. Stossel

Thomas P. Stossel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR IDENTIFYING AND TREATING MICROPARTICLE-ASSOCIATED DISEASES AND CONDITIONS
    Publication number: 20230398176
    Abstract: The present invention relates to compositions and methods for identifying and treating signature MP-associated diseases and conditions in subjects. In particular, treatment methods of the invention include administering a gelsolin agent to produce a therapeutic effect against a signature MP-associated disease or condition in a subject.
    Type: Application
    Filed: September 23, 2021
    Publication date: December 14, 2023
    Applicants: BioAegis Therapeutics Inc., University of Maryland, Baltimore
    Inventors: Susan L. Levinson, Stephen R. Thom, Mark J. DiNubile, Thomas P. Stossel
  • METHODS AND COMPOSITIONS FOR TREATING FRAILTY
    Publication number: 20230158107
    Abstract: This invention relates to the assessment of frailty conditions and methods of using gelsolin to treat frailty conditions.
    Type: Application
    Filed: May 3, 2021
    Publication date: May 25, 2023
    Inventors: Thomas P. Stossel, Timo E. Strandberg
  • COMPOSITIONS AND SYNERGISTIC METHODS FOR TREATING INFECTIONS
    Publication number: 20220339243
    Abstract: The present invention relates to compositions and methods for treating microbial infections in subjects, in particular methods of administering a gelsolin agent and an antimicrobial agent to produce a synergistic therapeutic effect against a microbial infection in a subject. The present invention also relates to methods for treating viral infections in subjects, including methods that include delayed-dosing methods and/or synergistic methods.
    Type: Application
    Filed: June 21, 2020
    Publication date: October 27, 2022
    Applicants: BioAegis Therapeutics Inc., President and Fellows of Harvard College
    Inventors: Mark J. DINUBILE, Susan L. LEVINSON, Thomas P. STOSSEL, Lester KOBZIK
  • Diagnostic and therapeutic uses of gelsolin in renal failure
    Patent number: 10272136
    Abstract: The invention is directed, in part, to the use of gelsolin to diagnose, monitor, and treat subjects with renal failure (e.g., chronic renal failure subjects on dialysis).
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: April 30, 2019
    Assignees: The General Hospital Corporation, The Brigham and Women's Hospital, Inc., Beth Israel Deaconess Medical Center, Inc.
    Inventors: Ravi Thadhani, Thomas P. Stossel, Po-Shun Lee, Ananth Karumanchi
  • Methods for treating or reducing the risk of arthritis in a subject by administering gelsolin
    Patent number: 10238715
    Abstract: The invention relates to the use of gelsolin to treat inflammatory diseases (e.g., rheumatoid arthritis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of inflammatory diseases (e.g., rheumatoid arthritis).
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: March 26, 2019
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Thomas P. Stossel, Anna Charlotta Teresia Magnuson Osborn, Andrej Tarkowski
  • Use of gelsolin to treat infections
    Patent number: 10022424
    Abstract: The invention relates to the use of gelsolin to treat infections and to monitor the treatment of infections. The invention also provides methods up-regulating interleukin expression and methods for down-regulating pro-inflammatory cytokine expression.
    Type: Grant
    Filed: May 12, 2005
    Date of Patent: July 17, 2018
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Thomas P. Stossel, Po-Shun Lee
  • USE OF GELSOLIN TO DIAGNOSE AND TREAT INFLAMMATORY DISEASES
    Publication number: 20170281724
    Abstract: The invention relates to the use of gelsolin to treat inflammatory diseases (e.g., rheumatoid arthritis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of inflammatory diseases (e.g., rheumatoid arthritis).
    Type: Application
    Filed: April 18, 2016
    Publication date: October 5, 2017
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Thomas P. Stossel, Teresia Anna Charlotta Magnuson Osborn, Andrej Tarkowski
  • DIAGNOSTIC AND THERAPEUTIC USES OF GELSOLIN IN RENAL FAILURE
    Publication number: 20170189483
    Abstract: The invention is directed, in part, to the use of gelsolin to diagnose, monitor, and treat subjects with renal failure (e.g., chronic renal failure subjects on dialysis).
    Type: Application
    Filed: January 17, 2017
    Publication date: July 6, 2017
    Inventors: RAVI THADHANI, THOMAS P. STOSSEL, PO-SHUN LEE, ANANTH KARUMANCHI
  • Multiphase systems for diagnosis of sickle cell disease
    Patent number: 9678088
    Abstract: An aqueous multi-phase system for diagnosis of sickle cell disease is described, including two or more phase-separated phases including: a first aqueous phase including a first phase component and having a first density between about 1.025 g/cm3 and about 1.095 g/cm3; and a second aqueous phase including a second phase component and having a second density between about 1.100 g/cm3 and about 1.140 g/cm3; wherein the first density is lower than the second density; and each of the first and second phase components include at least one polymer.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: June 13, 2017
    Assignees: President and Fellows of Harvard College, Children's Medical Center Corporation, The Brigham and Women's Hospital, Inc.
    Inventors: George M. Whitesides, Ashok A. Kumar, Jonathan W. Hennek, Caeul Lim, Yovany Moreno, Charles R. Mace, Manoj T. Duraisingh, Matthew R. Patton, Si-yi Ryan Lee, Gaetana D'Alesio-Spina, Carlo Brugnara, Thomas P. Stossel
  • Diagnostic and therapeutic uses of gelsolin in renal failure
    Patent number: 9575072
    Abstract: The invention is directed, in part, to the use of gelsolin to diagnose, monitor, and treat subjects with renal failure (e.g., chronic renal failure subjects on dialysis).
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: February 21, 2017
    Assignees: The Brigham and Women's Hospital, Inc., Beth Israel Deaconess Medical Center, Inc., The General Hospital Corporation
    Inventors: Ravi Thadhani, Thomas P. Stossel, Po-Shun Lee, Ananth Karumanchi
  • USE OF GELSOLIN TO DIAGNOSE AND TREAT INFLAMMATORY DISEASES
    Publication number: 20160228505
    Abstract: The invention relates to the use of gelsolin to treat inflammatory diseases (e.g., rheumatoid arthritis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of inflammatory diseases (e.g., rheumatoid arthritis).
    Type: Application
    Filed: April 18, 2016
    Publication date: August 11, 2016
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Thomas P. Stossel, Teresia Anna Charlotta Magnuson Osborn, Andrej Tarkowski
  • Use of gelsolin to diagnose and treat inflammatory diseases
    Patent number: 9316639
    Abstract: The invention relates to the use of gelsolin to treat inflammatory diseases (e.g., rheumatoid arthritis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of inflammatory diseases (e.g., rheumatoid arthritis).
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: April 19, 2016
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Thomas P. Stossel, Teresia Anna Charlotta Magnuson Osborn, Eric Leuchovius
  • USE OF GELSOLIN TO TREAT MULTIPLE SCLEROSIS AND TO DIAGNOSE NEUROLOGIC DISEASES
    Publication number: 20130230455
    Abstract: The invention relates to the use of gelsolin to treat neurologic diseases (e.g., multiple sclerosis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of neurologic diseases.
    Type: Application
    Filed: April 12, 2013
    Publication date: September 5, 2013
    Applicants: BloodCenter Research Foundation, Inc., THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Thomas P. Stossel, Po-Shun Lee, Bonnie Dittel, Katarzyna Maresz
  • Use of gelsolin to treat multiple sclerosis and to diagnose neurologic disease (stossel)
    Patent number: 8440622
    Abstract: The invention relates to the use of gelsolin to treat neurologic diseases (e.g., multiple sclerosis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of neurologic diseases.
    Type: Grant
    Filed: March 14, 2007
    Date of Patent: May 14, 2013
    Assignees: The Brigham and Women's Hospital, Inc., BloodCenter Research Foundation, Inc.
    Inventors: Thomas P. Stossel, Po-Shun Lee, Bonnie Dittel, Katarzyna Maresz
  • Prolonging Survival of Platelets Using CMP-Sialic Acid, UDP-Galactose or Both
    Publication number: 20130059287
    Abstract: The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to mediate hemostasis.
    Type: Application
    Filed: June 15, 2012
    Publication date: March 7, 2013
    Inventors: Keith M. Rosiello, Henrik Clausen, Hans Wandall, Thomas P. Stossel, John H. Hartwig, Karin M. Hoffmeister
  • USE OF GELSOLIN TO DIAGNOSE AND TREAT INFLAMMATORY DISEASES
    Publication number: 20120208743
    Abstract: The invention relates to the use of gelsolin to treat inflammatory diseases (e.g., rheumatoid arthritis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of inflammatory diseases (e.g., rheumatoid arthritis).
    Type: Application
    Filed: April 25, 2012
    Publication date: August 16, 2012
    Inventors: Thomas P. STOSSEL, Teresia Anna Charlotta Magnuson Osborn, Andrej Tarkowski, Erlc Leuchovius
  • Prolonging survival of platelets using CMP-sialic acid,UDP-galactose or both
    Patent number: 8221745
    Abstract: The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to mediate hemostasis.
    Type: Grant
    Filed: July 14, 2008
    Date of Patent: July 17, 2012
    Assignee: Velico Medical, Inc.
    Inventors: Keith M. Rosiello, Henrik Clausen, Hans Wandall, Thomas P. Stossel, John H. Hartwig, Karin M. Hoffmeister
  • Methods of using gelsolin levels to characterize a subject's risk of developing rheumatoid arthritis
    Patent number: 8198094
    Abstract: The invention relates to the use of gelsolin to treat inflammatory diseases (e.g., rheumatoid arthritis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of inflammatory diseases (e.g., rheumatoid arthritis).
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: June 12, 2012
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Thomas P. Stossel, Teresia Anna Charlotta Magnuson Osborn, Andrej Tarkowski, Eric Leuchovius, legal representative
  • COMPOSITIONS AND METHODS FOR PROLONGING SURVIVAL OF PLATELETS
    Publication number: 20110189151
    Abstract: The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to mediate hemostasis.
    Type: Application
    Filed: December 27, 2010
    Publication date: August 4, 2011
    Inventors: Thomas P. STOSSEL, John H. Hartwig, Karin M. Hoffmeister, Henrik Clausen
  • Methods for prolonging survival of platelets using UDP-galactose
    Patent number: 7858295
    Abstract: The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to mediate hemostasis.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: December 28, 2010
    Assignee: Velico Medical, Inc.
    Inventors: Thomas P. Stossel, John H. Hartwig, Karin M. Hoffmeister, Henrik Clausen