Patents by Inventor Thomas P. Stratton

Thomas P. Stratton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AZASPIRO WRN INHIBITORS
    Publication number: 20250230168
    Abstract: Inhibitors of Werner syndrome helicase are provided, including compounds of Formulas J, I, II, III, IIIa, IIIa-1, and IIIa-2, pharmaceutical compositions thereof, and methods of treating cancer.
    Type: Application
    Filed: December 20, 2024
    Publication date: July 17, 2025
    Inventors: Jason E. ANESINI, Peter A. BLOMGREN, Gediminas J. BRIZGYS, Gregory F. CHIN, Wilian Augusto CORTOPASSI COELHO, Raheel FONDEKAR, Cooper S. JAMIESON, Kerry E. JONES, Andrew V. KELLEGHAN, Scott E. LAZERWITH, Joshua L. MARTIN, Luisruben P. MARTINEZ, Jonathan William MEDLEY, Michael R. MISH, Michael L. MITCHELL, David E. MORTENSON, Sierra C. NGUYEN, Michael S. SANGI, Adam J. SCHRIER, Thomas P. STRATTON, Doris T. TANG, Chandrasekar VENKATARAMANI, William J. WATKINS
  • ANTIVIRAL INDOLINYL COMPOUNDS AND USES THEREOF
    Publication number: 20250171413
    Abstract: The present disclosure relates to indolinyl compounds. The present disclosure further relates to compounds that inhibit viral helicase-primase. The present disclosure further relates to the use of the compounds for the preparation a medicament for the treatment of diseases and/or condition through inhibiting viral helicase-primase. The present disclosure also relates to use of those compounds in the treatment of viral infections. The present disclosure further relates to intermediates for its preparation and to pharmaceutical compositions containing those compounds.
    Type: Application
    Filed: November 18, 2024
    Publication date: May 29, 2025
    Inventors: Aesop CHO, Thomas P. STRATTON
  • KRAS MODULATING COMPOUNDS
    Publication number: 20250042922
    Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.
    Type: Application
    Filed: June 27, 2024
    Publication date: February 6, 2025
    Inventors: Chaodi Dai, Julie Farand, Juan A. Guerrero, Tezcan Guney, Hongyan Guo, Jason R. Hudlicky, Darryl Kato, Irene N. Kiburu, Scott E. Lazerwith, Paulo A. Machicao Tello, James B.C. Mack, Erik P. McAuley, Jessica L. McKinley, Jonathan William Medley, Hyung-Jung Pyun, Thomas P. Stratton, Maoqun Tian, Jeremy R. Tuck, William J. Watkins, Jie Xu, Jennifer R. Zhang
  • Phospholipid compounds and uses thereof
    Patent number: 12208110
    Abstract: The present disclosure relates to compounds of Formula I, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for treatment of viral infections, for example for treatment of paramyxoviridae, pneumoviridae, picornaviridae, flaviviridae, filoviridae, arenaviridae, orthomyxovirus, and coronaviridae infections.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: January 28, 2025
    Assignee: Gilead Sciences, Inc.
    Inventors: Scott E. Lazerwith, Jonathan William Medley, Philip A. Morganelli, Thomas P. Stratton, Peiyuan Wang
  • KRAS Modulating Compounds
    Publication number: 20240383922
    Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.
    Type: Application
    Filed: April 10, 2024
    Publication date: November 21, 2024
    Inventors: Wilian Augusto Cortopassi Coelho, Chaodi Dai, Katherine De La Fuente, Julie Farand, Juan A. Guerrero, Tezcan Guney, Hongyan Guo, Safaa S. Jamshed, Darryl Kato, Irene N. Kiburu, Scott E. Lazerwith, James B.C. Mack, Joshua L. Martin, Jessica L. McKinley, Jonathan William Medley, Hyung-Jung Pyun, Thomas P. Stratton, Rhiannon Thomas-Tran, Maoqun Tian, Vickie H. Tsui, William J. Watkins, Jie Xu, Adam D. Zajdlik, Jennifer R. Zhang
  • Phospholipid compounds and uses thereof
    Patent number: 12030904
    Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
    Type: Grant
    Filed: April 14, 2023
    Date of Patent: July 9, 2024
    Assignee: Gilead Sciences, Inc.
    Inventors: Scott E. Lazerwith, Jonathan William Medley, Philip A. Morganelli, Devan Naduthambi, Thomas P. Stratton, Peiyuan Wang
  • Phospholipid compounds and uses thereof
    Patent number: 11963967
    Abstract: Compounds and methods of using said compounds, alone or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
    Type: Grant
    Filed: April 20, 2023
    Date of Patent: April 23, 2024
    Assignee: Gilead Sciences, Inc.
    Inventors: Scott E. Lazerwith, Jonathan William Medley, Philip A. Morganelli, Thomas P. Stratton, Peiyuan Wang
  • ANTIVIRAL INDOLINYL COMPOUNDS AND USES THEREOF
    Publication number: 20240101529
    Abstract: The present disclosure relates to indolinyl compounds. The present disclosure further relates to compounds that inhibit viral helicase-primase. The present disclosure further relates to the use of the compounds for the preparation a medicament for the treatment of diseases and/or condition through inhibiting viral helicase-primase. The present disclosure also relates to use of those compounds in the treatment of viral infections. The present disclosure further relates to intermediates for its preparation and to pharmaceutical compositions containing those compounds.
    Type: Application
    Filed: May 18, 2023
    Publication date: March 28, 2024
    Inventors: Aesop Cho, Katherine De La Fuente, Thomas P. Stratton, Peiyuan Wang, William J. Watkins, Jie Xu, Kin S. Yang
  • PHOSPHOLIPID COMPOUNDS AND USES THEREOF
    Publication number: 20240025932
    Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
    Type: Application
    Filed: June 9, 2023
    Publication date: January 25, 2024
    Inventors: Scott E. Lazerwith, Jonathan William Medley, Philip A. Morganelli, Devan Naduthambi, Thomas P. Stratton, Peiyuan Wang
  • Phospholipid compounds and uses thereof
    Patent number: 11773122
    Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
    Type: Grant
    Filed: August 23, 2021
    Date of Patent: October 3, 2023
    Assignee: Gilead Sciences. Inc.
    Inventors: Scott E. Lazerwith, Jonathan William Medley, Philip A. Morganelli, Devan Naduthambi, Thomas P. Stratton, Peiyuan Wang
  • PHOSPHOLIPID COMPOUNDS AND USES THEREOF
    Publication number: 20230250117
    Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
    Type: Application
    Filed: April 14, 2023
    Publication date: August 10, 2023
    Inventors: Scott E. Lazerwith, Jonathan William Medley, Philip A. Morganelli, Devan Naduthambi, Thomas P. Stratton, Peiyuan Wang
  • PHOSPHOLIPID COMPOUNDS AND USES THEREOF
    Publication number: 20230248753
    Abstract: Compounds and methods of using said compounds, alone or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
    Type: Application
    Filed: April 20, 2023
    Publication date: August 10, 2023
    Inventors: Scott E. Lazerwith, Jonathan William Medley, Philip A. Morganelli, Thomas P. Stratton, Peiyuan Wang
  • PHOSPHOLIPID COMPOUNDS AND USES THEREOF
    Publication number: 20220143052
    Abstract: Compounds and methods of using said compounds, alone or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
    Type: Application
    Filed: October 15, 2021
    Publication date: May 12, 2022
    Inventors: Scott E. Lazerwith, Jonathan William Medley, Philip A. Morganelli, Thomas P. Stratton, Peiyuan Wang
  • PHOSPHOLIPID COMPOUNDS AND USES THEREOF
    Publication number: 20220081455
    Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
    Type: Application
    Filed: August 23, 2021
    Publication date: March 17, 2022
    Inventors: Scott E. Lazerwith, Jonathan William Medley, Philip A. Morganelli, Devan Naduthambi, Thomas P. Stratton, Peiyuan Wang