Patents by Inventor Thomas Paccalet

Thomas Paccalet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of Sialic Acid in Plants
    Publication number: 20170247714
    Abstract: A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5 Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.
    Type: Application
    Filed: March 30, 2017
    Publication date: August 31, 2017
    Applicants: Medicago, Inc., Centre National de la Recherche Scientifique, Universite De Rouen
    Inventors: Thomas PACCALET, Muriel BARDOR, Christophe RIHOUEY, Véronique GOMORD, Loïc FAYE, Patrice LEROUGE, Stéphanie AQUIN, Louis-Philippe VEZINA, Marc-André D'AOUST
  • Synthesis of sialic acid in plants
    Patent number: 9657305
    Abstract: A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: May 23, 2017
    Assignees: Medicago Inc., Centre National de la Recherche Scientifique, Universite De Rouen
    Inventors: Thomas Paccalet, Muriel Bardor, Christophe Rihouey, Véronique Gomord, Loïc Faye, Patrice Lerouge, Stéphanie Aquin, Louis-Philippe Vezina, Marc-André D'Aoust
  • SYNTHESIS OF SIALIC ACID IN PLANTS
    Publication number: 20160145664
    Abstract: A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.
    Type: Application
    Filed: November 4, 2015
    Publication date: May 26, 2016
    Applicants: Medicago Inc., Centre National de la Recherche Scientifique, Universite De Rouen
    Inventors: Thomas PACCALET, Muriel BARDOR, Christophe RIHOUEY, Véronique GOMORD, Loïc FAYE, Patrice LEROUGE, Stéphanie AQUIN, Louis-Philippe VEZINA, Marc-André D'AOUST
  • Synthesis of sialic acid in plants
    Patent number: 9212372
    Abstract: A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5 Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: December 15, 2015
    Assignees: Medicago Inc., Centre National de la Recherche Scientifique, Université De Rouen
    Inventors: Thomas Paccalet, Muriel Bardor, Christophe Rihouey, Véronique Gomord, Loïc Faye, Patrice Lerouge, Stéphanie Aquin, Louis-Philippe Vezina, Marc-André D'Aoust
  • MODIFYING GLYCOPROTEIN PRODUCTION IN PLANS
    Publication number: 20110008837
    Abstract: A method for synthesizing a protein of interest with a modified N-glycosylation profile within a plant, a portion of a plant, or a plant cell is provided. The method comprises co-expressing within a plant a nucleotide sequence encoding a first nucleotide sequence encoding a hybrid protein (GNT1-GalT) comprising a CTS domain of N-acetylglucosaminyl transferase (GNT1) fused to a catalytic domain of beta-1,4galactosyltransferase (GalT), the first nucleotide sequence operatively linked with a first regulatory region that is active in the plant, and a second nucleotide sequence for encoding the protein of interest, the second nucleotide sequence operatively linked with a second regulatory region that is active in the plant. The first and second nucleotide sequences are co-expressed to synthesize a protein of interest comprising glycans with the modified N-glycosylation profile within the plant, the portion of the plant, or the plant cell.
    Type: Application
    Filed: June 13, 2008
    Publication date: January 13, 2011
    Inventors: Marc-Andre D-Aoust, Louis-Philippe Vezina, Stephanie Aquin, Estelle Marquet-Blouin, Muriel Bardor, Veronique Gomord, Christophe Rihouey, Thomas Paccalet, Carole Burel, Loic Faye, Patrice Lerouge, Christophe Sourrouille
  • Synthesis of Sialic Acid in Plants
    Publication number: 20090312240
    Abstract: A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated a protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5 Ac synthase, CMP-Neu5Ac transporter and a sialyltransferase.
    Type: Application
    Filed: February 9, 2007
    Publication date: December 17, 2009
    Inventors: Thomas Paccalet, Muriel Bardor, Chirstophe Rihouey, Véronique Gomord, Loïc Faye, Patrice Lerouge, Stéphanie Aquin, Louis-Philippe Vezina, Marc-André D'Aoust