Abstract: Disclosed herein are heterocyclic compounds that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific inhibitors of menin-MLL interaction. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the menin-MLL inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL interaction.

Abstract: A magnet includes a stack of a plurality of superconducting pancake wound coils having a stacking axis normal to a winding direction of the coils. The stack has axial ends and has a stack midplane relative to the stacking axis. A quench detector is provided for detecting a quench in the stack of superconducting pancake wound coils. A plurality of resistance quench heaters (RQH) are distributed symmetrically along the axis with respect to the stack midplane. Control circuitry is provided for controlling the operation of the RQH upon the detection of a quench by the quench detector. A method of quenching a magnet is also disclosed.

Abstract: Disclosed is the integration of the production of acetic anhydride from ketene, and the acetylation of wood using acetylation fluid comprising acetic acid and acetic anhydride. The invention involves recirculating acetylation fluid recovered from wood acetylation to a unit for the production of acetic anhydride from acetic acid and ketene. The acetic anhydride product stream can, in turn, be directly used as a wood acetylation fluid.

Abstract: A superconducting magnet which provides a barrier to current flow transverse to the length of the superconductor at operational temperature and voltages, while also providing a magnetic quench protection mechanism for the superconducting magnet. The superconducting magnet comprising a plurality of winding turns of superconductive material wound into a coil and a variable electrically resistive layer varying with either temperature or voltage positioned between at least of portion of the plurality of winding turns of the superconductive material, wherein the variable electrically resistive layer has a negative temperature coefficient of resistance or is a semiconductor with a threshold voltage greater than operational voltages.

Abstract: Disclosed is the integration of the production of acetic anhydride from ketene, and the acetylation of wood using acetylation fluid comprising acetic acid and acetic anhydride. The invention involves directly using raw acetic anhydride as obtained in the production thereof from ketene, as a wood acetylation fluid.

Abstract: Disclosed is the integration of the production of acetic anhydride from ketene, and the acetylation of wood using acetylation fluid comprising acetic acid and acetic anhydride. The invention involves combining acetic acid obtained from distillation of acetylation fluid with a residual aqueous acetic acid stream as obtained from ketene production.

Abstract: Disclosed is the integration of the production of acetic anhydride from ketene, and the acetylation of wood using acetylation fluid comprising acetic acid and acetic anhydride. The invention involves combining acetic acid obtained from distillation of acetylation fluid with a residual aqueous acetic acid stream as obtained from ketene production.

Abstract: Disclosed is the integration of the production of acetic anhydride from ketene, and the acetylation of wood using acetylation fluid comprising acetic acid and acetic anhydride. The invention involves directly using raw acetic anhydride as obtained in the production thereof from ketene, as a wood acetylation fluid.

Abstract: Disclosed is the integration of the production of acetic anhydride from ketene, and the acetylation of wood using acetylation fluid comprising acetic acid and acetic anhydride. The invention involves recirculating acetylation fluid recovered from wood acetylation to a unit for the production of acetic anhydride from acetic acid and ketene. The acetic anhydride product stream can, in turn, be directly used as a wood acetylation fluid.

Abstract: A method for making a composite superconductor and a superconductor made using the method. Superconducting filaments are embedded in a matrix material. Oxygen-containing elements are also embedded in the matrix material, with the oxygen-containing elements preferably being dispersed evenly among the superconducting filaments. A surrounding reinforcement material contains the other elements and preferably seals the superconductor from the surrounding atmosphere.

Abstract: A method for making a composite superconductor and a superconductor made using the method. Superconducting filaments are embedded in a matrix material. Oxygen-containing elements are also embedded in the matrix material, with the oxygen-containing elements preferably being dispersed evenly among the superconducting filaments. A surrounding reinforcement material contains the other elements and preferably seals the superconductor from the surrounding atmosphere.

Abstract: A cable-in-conduit-conductor (CICC) joint for use with a hybrid magnet. An elongate copper member is disposed in sandwiched relation between a first and second cable that are disposed in parallel, spaced apart relation to one another. A first elongate member is disposed in overlying relation to the first cable and a second elongate member is disposed in underlying relation to the second cable. All of the parts are positioned within a joint box, and the joint box is sandwiched between first and second flat plates that are interconnected to one another by elongate bolts. Tightening the bolts compresses the parts within the joint box. A heat treatment completes the solderless joint.

Abstract: A system for presenting a visual dashboard which presents real time information regarding health of business processes through the health of the underlying IT systems. Visual representation of the relationships of the underlying application architecture are also presented via the system. In certain embodiments, the system develops a visual hierarchy which represents the relationship of business processes and the underlying IT infrastructure, thus enabling presentation of information both about the health of the components, as well as the relationship between the components.

Abstract: A new type of conductor well-suited for use in a superconducting electromagnet. The conductor comprises a single electrically conductive member at its core. The conductor may include concentric layers of dissimilar materials. This conductor is surrounded by a channel through which coolant—typically liquid helium—can flow. The channel is bounded by a metal conduit of sufficient strength to withstand the Lorentz forces. The metal conduit is covered by an insulator which forces the current into the desired helical path.

Abstract: A magnetic shimming configuration for a high-field magnet having optimized turn geometry and electrical circuitry. The present invention accomplishes this by combining the corrective functionalities of the standard X and ZX shims into two single, simplified electrical circuits and conductors, optimized for field strength as a function of turn location. The standard Y and ZY shims were also replaced with two single, simplified circuits and conductor that is corrective of the Y and ZY fields. The new configuration also eliminates the need of additional “second, outboard turns” of the traditional X, ZX, Y, and ZY shims, located further away from the mid-plane.

Abstract: A wide bore, high field superconducting magnet. The superconducting magnet has a plurality of superconducting coils impregnated with epoxy and nested within each other. An innermost one of the nested coils has a bore therethrough that defines a bore width of the magnet. The bore width is greater than approximately 100 millimeters. The nested coils are electrically connected in series and cooled to an operating temperature less than approximately 4 degrees K. The magnet also has external reinforcements on the coils that are applied prior to impregnating the coils with epoxy. An active protection circuit protects the coils in response to a quench in the magnet. The protection circuit includes heater elements positioned in thermal contact with the coils prior to impregnating the coils with epoxy. The magnet further has lead supports for supporting the lead wires with epoxy that extend from the coils.

Abstract: A wide bore, high field superconducting magnet. The superconducting magnet has a plurality of superconducting coils impregnated with epoxy and nested within each other. An innermost one of the nested coils has a bore therethrough that defines a bore width of the magnet. The bore width is greater than approximately 100 millimeters. The nested coils are electrically connected in series and cooled to an operating temperature less than approximately 4 degrees K. The magnet also has external reinforcements on the coils that are applied prior to impregnating the coils with epoxy. An active protection circuit protects the coils in response to a quench in the magnet. The protection circuit includes heater elements positioned in thermal contact with the coils prior to impregnating the coils with epoxy. The magnet further has lead supports for supporting the lead wires with epoxy that extend from the coils.

Abstract: Method of manufacture a wide bore, high field superconducting magnet. The superconducting magnet has a plurality of superconducting coils impregnated with epoxy and nested within each other. An innermost one of the nested coils has a bore therethrough that defines a bore width of the magnet. The bore width is greater than approximately 100 millimeters. The nested coils are electrically connected in series and cooled to an operating temperature less than approximately 4 degrees K. The magnet also has external reinforcements on the coils that are applied prior to impregnating the coils with epoxy. An active protection circuit protects the coils in response to a quench in the magnet. The protection circuit includes heater elements positioned in thermal contact with the coils prior to impregnating the coils with epoxy. The magnet further has lead supports for supporting the lead wires with epoxy that extend from the coils.