Abstract: Engineered antibody compounds and conjugates thereof, are provided, said antibody compounds and conjugates thereof are useful as agents for cancer immunotherapy. Engineered antibody compounds may include one or more amino acid residue substitutions within the constant regions of the antibody engineered into a parental antibody. Amino acid residue substitutions may include substitution of cysteine or alanine.

Abstract: The present invention relates to sulfur based polymers and a process of making sulfur based polymers. The invention also relates to sorbents comprising the sulfur-based polymers. The invention also relates to the use of such polymers and sorbents in metal remediation or extraction. The invention also relates to methods of removing heavy metals from fluids.

Abstract: Methods are provided for fabricating electrochromic devices that mitigate formation of short circuits under a top bus bar without predetermining where top bus bars will be applied on the device. Devices fabricated using such methods may be deactivated under the top bus bar, or may include active material under the top bus bar. Methods of fabricating devices with active material under a top bus bar include depositing a modified top bus bar, fabricating self-healing layers in the electrochromic device, and modifying a top transparent conductive layer of the device prior to applying bus bars.

Abstract: Systems and methods to cut a closing loop to deploy a parachute. The system includes a cutter with a body with a cutter opening that extends through the body and a blade that is movable across the cutter opening. Processing circuitry is configured to signal the cutter to move the blade across the cutter opening. A mount includes a base, a retainer with a channel sized to receive the cutter, and a mount opening that extends through the mount and across the channel. The cutter is configured to fit within the channel with the cutter opening aligned with the mount opening to form a through-opening such that the closing loop extends through the cutter and the mount.

Abstract: An access door may include a core, first and second stiles defined along opposites sides of the core such that the core between the first and second stiles defines a recessed pocket with each of the first and second stiles defining a channel therein extending longitudinally along an inwardly-facing edge thereof, bottom and top elongated panels each defining tongue members at opposite sides thereof and configured to be received transversely in the recessed pocket with the tongue members received within the channels defined along the inwardly-facing edges of the first and second stiles, wherein, with the top and bottom elongated panels received in the recessed pocket, exterior faces of the first and second stiles, exterior faces of the top and bottom elongated panels, and an exposed surface of the recessed pocket between the top and bottom elongated panels define an exterior surface of one side of the door.

Abstract: A ceiling ladder having a plurality of sections that can be climbed by a user when in an unfolded position into an attic and that can be folded together into a retracted position to be stored above the ceiling. The ladder has a deep step, which has a width greater than the width of other steps of the ladder, in which is located between about 2-5 feet from the floor when the ladder is in the unfolded position so that a user can stand on the deep step and place objects into the attic without having to climb into the attic.

Abstract: In some embodiments, a multipurpose ladder has a first inner section. The ladder has a first articulated hinge and a second articulated hinge. The ladder has a second inner section. The ladder has a first outer section. The ladder has a first locking bar. The ladder has a second outer section. The multipurpose ladder may have a plurality of brackets disposed about outer rails of the outer sections. The brackets provide support to each of the outer rails and strengthens them against bending forces so the rails can be thinner and of lighter weight. The ladder may have an ANSI duty rating of 1 A or an ANSI duty rating of 1 AA.

Abstract: Disclosed herein are embodiments of an urn comprising an attachment communication module allowing nearby users to access digital memories associated with the communication module.

Abstract: A multipurpose ladder having a first inner section. The ladder has a first articulated hinge and a second articulated hinge. The ladder has a second inner section. The ladder has a first outer section. The ladder has a first locking bar. The ladder has a second outer section. The multipurpose ladder may have a plurality of brackets disposed about outer rails of the outer sections. The brackets provide support to each of the outer rails and strengthens them against bending forces so the rails can be thinner and of lighter weight. The ladder may have an ANSI duty rating of 1A or an ANSI duty rating of 1AA. A method for using a multipurpose ladder. A method for producing a multipurpose ladder.

Abstract: Systems and methods to cut a closing loop to deploy a parachute. The system includes a cutter with a body with a cutter opening that extends through the body and a blade that is movable across the cutter opening. Processing circuitry is configured to signal the cutter to move the blade across the cutter opening. A mount includes a base, a retainer with a channel sized to receive the cutter, and a mount opening that extends through the mount and across the channel. The cutter is configured to fit within the channel with the cutter opening aligned with the mount opening to form a through-opening such that the closing loop extends through the cutter and the mount.

Abstract: Aspects of the present disclosure include a connector that interfaces a beverage dispenser with an external water supply. The connector includes a backflow preventer that only allows water to flow from the external water supply to the beverage dispenser. Some aspects of the connector also include a pressure regulator configured to reduce incoming water pressure to a desired pressure. The connector is configured to be mounted to a suitable surface, such as the rear of the beverage dispenser.

Abstract: Systems and methods to cut a closing loop to deploy a parachute. The system includes a cutter with a body with a cutter opening that extends through the body and a blade that is movable across the cutter opening. Processing circuitry is configured to signal the cutter to move the blade across the cutter opening. A mount includes a base, a retainer with a channel sized to receive the cutter, and a mount opening that extends through the mount and across the channel. The cutter is configured to fit within the channel with the cutter opening aligned with the mount opening to form a through-opening such that the closing loop extends through the cutter and the mount.

Abstract: A jobsite box includes a body, the body having an interior, an exterior, and a lid, a key pad positioned on the exterior of the body, the key pad being in communication with a controller positioned on the body, a locking mechanism connected to the body, the locking mechanism being configured to lock and unlock the jobsite box, a battery positioned in the interior of the body, the battery configured to power the locking mechanism. The controller is configured to lock or unlock the locking mechanism when a predetermined code is entered into the key pad.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; Wherein R1, R3-R6, X2 and X3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: Systems and methods to cut a closing loop to deploy a parachute. The system includes a cutter with a body with a cutter opening that extends through the body and a blade that is movable across the cutter opening. Processing circuitry is configured to signal the cutter to move the blade across the cutter opening. A mount includes a base, a retainer with a channel sized to receive the cutter, and a mount opening that extends through the mount and across the channel. The cutter is configured to fit within the channel with the cutter opening aligned with the mount opening to form a through-opening such that the closing loop extends through the cutter and the mount.

Abstract: An apparatus includes a platform having a first end and a second end and a handle. The apparatus includes a first leg assembly rotatably attached to the platform in proximity to the first end. The apparatus includes a second leg assembly attentively attached to the platform in proximity to the second end. When the first and second leg assemblies are essentially perpendicular to the platform, the apparatus is in a use state and the user is able to stand on the platform and be supported by the first and second leg assemblies. When the apparatus is in the use state, the user is able to pick up the apparatus by the handle with only one of the hands without tipping the apparatus. A method for a user with hands to stand on an apparatus. A work platform having legs which are coplanar with the platform when the legs are in a closed position. The work platform having a hinge bracket with a tab against which a leg contacts and is stopped when the leg is in an open position.

Abstract: A policy management system can manage a set of insurance policies, for example by performing automated operations to renew policies for subsequent terms. Some insurance policies may be associated with the same household, company, or other insured party, but may be associated with different cars or other insured elements. The policy management system can have a policy consolidator that identifies database records for a target policy and a related source policy, and can consolidate data from the source policy into the record of the target policy. Thereafter, the policy management system can perform policy renewal operations and other policy management operations together based on the consolidated data in the record for the target policy.

Abstract: A ceiling ladder having a plurality of sections that can be climbed by a user when in an unfolded position into an attic and that can be folded together into a retracted position to be stored above the ceiling. The ladder has a deep step, which has a width greater than the width of other steps of the ladder, in which is located between about 2-5 feet from the floor when the ladder is in the unfolded position so user can stand on the deep step in place objects into the attic without having to climb into the attic. A method. A deep step.

Abstract: An assembly upon which a user stands includes a platform. The assembly includes a first work stand and a second work stand. Each work stand has a front frame and a rear frame. The assembly includes a first plank adapter engaged with the first work stand. The first plank adapter has an attachment portion and a bar. The assembly includes a second plank adapter engaged with the second work stand. The platform rests on and is supported by the first and second plank adapters. The present invention pertains to a work stand for holding a platform upon which a user stands. A plank adapter that is engaged with a front frame of a work stand to hold a platform. A method for a user to stand above ground. A method for forming a work stand.

Abstract: A ceiling ladder having a plurality of sections that can be climbed by a user when in an unfolded position into an attic and that can be folded together into a retracted position to be stored above the ceiling. The ladder has a deep step, which has a width greater than the width of other steps of the ladder, in which is located between about 2-5 feet from the floor when the ladder is in the unfolded position so user can stand on the deep step in place objects into the attic without having to climb into the attic. A deep step for a ceiling ladder.