Abstract: A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.

Abstract: The present invention relates to an additive manufacturing process using a composition comprising the reaction product of a polyester polyol and a compound comprising at least one functional group that can react with a hydroxyl-group of the polyester polyol and at least one further functional group, selected from acrylate- or methacrylate-group, wherein the polyester polyol is based on at least one organic acid comprising at least two carboxyl groups or its anhydride and at least one polyol comprising at least two hydroxy-groups, wherein the reaction product has a glass transition temperature Tg of below 23° C., wherein the composition optionally further comprises a photoinitiator, as a photopolymerisable material in.

Abstract: Systems and methods for a sale authorization include detecting vehicle information. A secondary authorization parameter is received and the sale is authorized in response to the secondary authorization parameter being associated with the vehicle information.

Abstract: Systems and methods for a sale authorization include detecting vehicle information. A secondary authorization parameter is received and the sale is authorized in response to the secondary authorization parameter being associated with the vehicle information.

Abstract: The present invention relates to a formulation comprising: i) at least one hydrolysate of at least one compound of formula (I) RSi(OX)3 (I) where X, the same or different, is H, C1-C4 alkyl or acyl, R=OX, OH, C1-C4 alkyl or alkoxy silyl-substituted ethylene radical, ii) at least one hydrolysate of at least one polyisocyanurate bearing alkoxy silyl alkyl units, iii) at least one polymer bearing hydroxyl groups, and iv) a solvent mixture containing water comprising at least one alcohol with 1 to 4 carbon atoms, wherein the pH value of the formulation lies in a range from 1.8-4.7, preferably from 3-4.5, and the content of the polymer bearing hydroxyl groups ranges from 13 wt. % to 33 wt. % related to the solids content in the formulation. The invention further relates to a method for the production of said formulation, the use thereof in the production of laminate structures and corresponding laminate structures having at least two layers comprising the formulation.

Abstract: Systems and methods for a sale authorization include detecting vehicle information. A secondary authorization parameter is received and the sale is authorized in response to the secondary authorization parameter being associated with the vehicle information.

Abstract: The present invention is directed to a fuel dispenser system and a system for managing dispenser systems. The system comprises of at least one fuel dispenser having a peripheral, a point of sale terminal for initiating dispensing transactions and for controlling the peripheral on the fuel dispenser and a processor connected between the point of sale terminal and the dispenser for translating commands between the point-of-sale terminal and the dispenser and for translating response between dispenser and the point-of sale terminal. The present invention also includes a managing processor communicating with each dispenser system for administering the activities of the dispenser system.