Abstract: Computer systems and corresponding methods are provided for computer assisted research in a network are provided that generate interface screens that include a map view of a plurality of selectable objects disposed in a nuclear arrangement in segmented rings about a first level object. The computing device is configured to receive selections of the displayed objects and expand the display to include additional segmented levels all surrounding the first level object.

Abstract: Computer systems and corresponding methods are provided for computer assisted research in a network are provided that generate interface screens that include a map view of a plurality of selectable objects disposed in a nuclear arrangement in segmented rings about a first level object. The computing device is configured to receive selections of the displayed objects and expand the display to include additional segmented levels all surrounding the first level object.

Abstract: Computer systems and corresponding methods are provided for computer assisted research in a network are provided that generate interface screens that include a map view of a plurality of selectable objects disposed in a nuclear arrangement in segmented rings about a first level object. The computing device is configured to receive selections of the displayed objects and expand the display to include additional segmented levels all surrounding the first level object.

Abstract: Aspects of the subject disclosure may include, for example, a method comprising receiving a data stream comprising media content that includes program content and advertising content, and monitoring for presence of markers in the data stream at test points on a data path from a receiving device to a server distributing the data stream over a network. Data collected at the test points is correlated to determine whether the advertising content was presented. If the advertising content was not presented, an alarm message is generated; and a location is determined, based on the result of the correlating, of a fault on the data path causing the advertising content to not be presented. The test data are collected from the test points simultaneously with propagation of the data stream along the data path. Other embodiments are disclosed.

Abstract: Aspects of the subject disclosure may include, for example, a method comprising receiving a data stream comprising media content that includes program content and advertising content, and monitoring for presence of markers in the data stream at test points on a data path from a receiving device to a server distributing the data stream over a network. Data collected at the test points is correlated to determine whether the advertising content was presented. If the advertising content was not presented, an alarm message is generated; and a location is determined, based on the result of the correlating, of a fault on the data path causing the advertising content to not be presented. The test data are collected from the test points simultaneously with propagation of the data stream along the data path. Other embodiments are disclosed.

Abstract: A video processing method includes receiving a multimedia file including a first video file encrypted with a first compression algorithm and converting the first video file to a second video file, which is encrypted with a second compression algorithm. The method includes extracting, from the second file, video data indicative of at least one video characteristic of the second file and displaying the video data on a display screen or forwarding the video data to a content insertion server. The first video compression algorithm may be a MPEG-2 video compression algorithm and the second video compression algorithm may be an H.264 algorithm and/o an H.265 algorithm. The video data may include run time data indicative of a run time of the second video file, frame rate data indicative of a frame rate of the second video file, and pixel data indicative of a resolution of the second video file.

Abstract: A video processing method includes receiving a multimedia file including a first video file encrypted with a first compression algorithm and converting the first video file to a second video file, which is encrypted with a second compression algorithm. The method includes extracting, from the second file, video data indicative of at least one video characteristic of the second file and displaying the video data on a display screen or forwarding the video data to a content insertion server. The first video compression algorithm may be a MPEG-2 video compression algorithm and the second video compression algorithm may be an H.264 algorithm and/o an H.265 algorithm. The video data may include run time data indicative of a run time of the second video file, frame rate data indicative of a frame rate of the second video file, and pixel data indicative of a resolution of the second video file.

Abstract: A video processing method includes receiving a multimedia file including a first video file encrypted with a first compression algorithm and converting the first video file to a second video file, which is encrypted with a second compression algorithm. The method includes extracting, from the second file, video data indicative of at least one video characteristic of the second file and displaying the video data on a display screen or forwarding the video data to a content insertion server. The first video compression algorithm may be a MPEG-2 video compression algorithm and the second video compression algorithm may be an H.264 algorithm and/o an H.265 algorithm. The video data may include run time data indicative of a run time of the second video file, frame rate data indicative of a frame rate of the second video file, and pixel data indicative of a resolution of the second video file.

Abstract: A video processing method includes receiving a multimedia file including a first video file encrypted with a first compression algorithm and converting the first video file to a second video file, which is encrypted with a second compression algorithm. The method includes extracting, from the second file, video data indicative of at least one video characteristic of the second file and displaying the video data on a display screen or forwarding the video data to a content insertion server. The first video compression algorithm may be a MPEG-2 video compression algorithm and the second video compression algorithm may be an H.264 algorithm and/o an H.265 algorithm. The video data may include run time data indicative of a run time of the second video file, frame rate data indicative of a frame rate of the second video file, and pixel data indicative of a resolution of the second video file.

Abstract: A universal rewards system for consolidating reward and bonus programs across a series of programs in which a consumer participates. The system includes at least one computer having a computer-readable medium with program instructions stored thereon to cause the processor to receive data streams regarding participating merchants, determine and/or identify qualified transactions, identify appropriate rewards/bonuses, and identify participating consumers, generate data regarding the qualified transactions and the appropriate rewards/bonuses, and transmit information regarding the qualified transactions and issuance of the appropriate rewards/bonuses. The system also includes an identification device for distribution to the participating consumers.

Abstract: The invention encompasses systems, methods, and apparatus for predicting and monitoring an individual's response to a therapeutic regimen. The invention includes multiple virtual patients, an associating subsystem operable to associate the subject with one or more of the virtual patients, and a simulation engine operable to apply one or more experimental protocols to the one or more virtual patients identified with the subject to generate a set of outputs.

Abstract: An apparatus and method for validating a computer model is described. In one embodiment, a computer-readable medium comprises instructions to associate a set of configurations of a computer model with a stimulus-response test, each configuration of the set of configurations representing a different model scenario, the stimulus-response test defining a modification to each configuration of the set of configurations. The computer-readable medium also comprises instructions to apply the stimulus-response test to the set of configurations to produce a simulated response for each configuration of the set of configurations and instructions to compare the simulated responses for the set of configurations with an expected response to the stimulus-response test.

Abstract: The invention encompasses novel computer models of chemical sensitivity of skin and systems for predicting chemical sensitivity of skin. In particular, the computer model of chemical sensitivity of skin comprises a) an epidermal compartment comprising a mathematical representation of exposure of an epidermal tissue to a chemical and a mathematical representation of a first population of antigen presenting cells interacting with the chemical; and b) a lymph node compartment comprising a mathematical representation of a second population of antigen presenting cells, and a mathematical representation of a population of T cells, wherein at least a subpopulation of the population of T cells interacts with the second population of antigen presenting cells.

Abstract: The invention encompasses novel methods for developing a computer model of a mammalian respiratory system. In particular, the models include representations of biological processes associated with obstruction of the respiratory system with constriction of the respiratory system. The invention also encompasses computer models of respiratory systems, methods of simulating respiratory systems and computer systems for simulating respiratory systems.

Abstract: The invention encompasses novel methods for developing a computer model of type 1 diabetes in a mammal. In particular, the models can include representations of biological processes associated with a pancreatic lymph node and one or more pancreatic islets. Alternatively, the models can include representations of biological processes associated with at least two conditions selected from the group consisting of autoreactive T cell production, autoreactive T cell priming, insulitis and hyperglycemia. The invention also provides methods for developing a computer model of a non-insulin replacement treatment of type 1 diabetes. The invention also encompasses computer models of type 1 diabetes, methods of simulating type 1 diabetes and computer systems for simulating type 1 diabetes and the uses thereof.

Abstract: The invention encompasses methods, including computer-implemented methods, of defining a virtual patient population and mapping the virtual patient population to a population of real patients. The invention utilizes virtual measures from one or more virtual patients, and data representative of multiple real subjects in a sample population, such as data collected from patients in a clinical trial or epidemiological study of a real population. The invention includes evaluating the similarity between the virtual patients and the real subjects, and assigning prevalences to the virtual patients based on the evaluation. The similarity can be assessed using some or all of the virtual measures of the virtual patients and some or all of the data obtained for the real subjects. Any of various goodness-of-fit measures can be used to evaluate the similarity or to help identify prevalences. The virtual patient population is defined as the virtual patients according to their respective prevalences.

Abstract: The invention encompasses novel methods for developing a computer model of cholesterol metabolism in an animal. In particular, the models include representations of biological processes associated with both lipid flux and lipoprotein particles. The invention also encompasses computer models of cholesterol metabolism, methods of simulating cholesterol metabolism and computer systems for simulating cholesterol metabolism.

Abstract: The present invention relates to a mathematical and computer model of a joint. The model includes representation of the biological processes related to the synovial tissue and cartilage. In one embodiment, the model represents a human joint afflicted with rheumatoid arthritis.

Abstract: A method of conducting a sequence of linked simulation operations, utilizing a computer-based simulation model, commences with the performance of a first simulation operation to generate an output condition. A further simulation operation, which is defined to sequentially follow the first simulation operation, is then formed utilizing the simulation model. The second simulation operation at least partially and automatically inherits the output condition generated by the first simulation operation as an input condition. In this way, the second simulation operation commences with a configuration captured from a preceding simulation operation as an input condition. Multiple simulation operations may at least partially inherit a configuration from the first simulation operation.

Abstract: The invention encompasses systems, methods, and apparatus for predicting and monitoring an individual's response to a therapeutic regimen. The invention includes multiple virtual patients, an associating subsystem operable to associate the subject with one or more of the virtual patients, and a simulation engine operable to apply one or more experimental protocols to the one or more virtual patients identified with the subject to generate a set of outputs.